DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7183 and ccdc174

DIOPT Version :9

Sequence 1:	NP_001262701.1	Gene:	CG7183 / 42181	FlyBaseID:	FBgn0038583	Length:	568	Species:	Drosophila melanogaster
Sequence 2:	XP_021332539.1	Gene:	ccdc174 / 541361	ZFINID:	ZDB-GENE-050320-54	Length:	468	Species:	Danio rerio

Alignment Length:	530	Identity:	144/530 - (27%)
Similarity:	233/530 - (43%)	Gaps:	131/530 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 AISVNL---SSLLSLKAELLRKQHEVRVAKATKASAADFRPTKSAGNKE---KSSDQGYKKVASS 65
            |.||:|   |.|:.|||||.|||.:.:..:..:.:....:.:|:...|.   ...::|....|..
Zfish    12 ASSVSLFFISMLVDLKAELYRKQEQFKHDRLGQDAGGGAQKSKTKIKKPNIWSKQNEGVNARAQK 76

  Fly    66 DDGAKVYE-AEDHAQLEKSRRILEAKSKFYDRMSRNGGSLNSDDN---CLVMFNRKKQEADREPE 126
            |    |.: ||:...|:|||:.||.|::.|::|::  |....::.   .||.|.:|......||:
Zfish    77 D----VQQTAEEENTLDKSRQKLEEKARLYEQMTK--GDFPDEETESLFLVDFTQKIINQRNEPQ 135

  Fly   127 QCTQRR---ESRQRLSSSSSSSQDEEGHDDLEVEYVDCLGRTRKCLRKDLKEAKRRDKQLAESMP 188
            ..|..|   :|..::......:.:||.     |:|||.|||:|:||||||.:.::.|:.|
Zfish   136 TRTADRDGEDSDVKVPVPPPQNTNEEW-----VDYVDALGRSRRCLRKDLPDFQKMDEDL----- 190

  Fly   189 ERLDQTKANWMINTKGSRELNSNHNSDDESFIGPRPTESVFSEALSTMTKHDEQRMNWERKEQEN 253
                                   ||         :.........||...:.:.||..|||:|:|.
Zfish   191 -----------------------HN---------KRVTGADRHLLSEDMRREMQREEWEREEEEQ 223

  Fly   254 FEKP--DVHYQDVFFDEARTHGVGYYAFSTDEDERRQQQLDLEKARQATKAKQMRRDELRAQRDR 316
            .::|  .:||:::...|||..||||:||:.|||:||:|:..|:..|..|..::.:|::|:.:|..
Zfish   224 MKRPVGPIHYENIRDQEARELGVGYFAFAHDEDQRRKQRETLDMLRDQTTEQRSKREQLKEKRKA 288

  Fly   317 LVADRVLAAKNRIRE-RNG-LPPISEE-----DYLREEQQKKDE-LAKEEAELNRAEQERRAAIE 373
            |:..|:  ||.|:|. :|| :.|..|:     |....::..||| |....|             .
Zfish   289 LLEARL--AKVRMRRMKNGKMEPGDEQVAPAADVAEIDEDDKDEDLVGPPA-------------P 338

  Fly   374 RKKEKEEAELEELRKE------HVRDWDKNKPGVRKLADSESAEPPEEEWKYKAERLPMSQEEWN 432
            .|..|.|.|::| ||:      |||:||:.|               |..|           .:|.
Zfish   339 AKVPKVEVEIQE-RKDTKPGVPHVREWDRGK---------------EFSW-----------GQWT 376

  Fly   433 EKQRAQRHAEFAPMPEP--VPLKRSNFSSMPPPMVWNRAQEPQFHNFHSTKEEKKFQRRSY-SAN 494
            .::|.:|.:|||| |..  ...:|:|.|        ...|....|.|...:.:...:|.:. :.:
Zfish   377 SRRREERDSEFAP-PSAYFAEDRRANHS--------RAGQSKGKHGFKWPESQNAAERHTEDNTS 432

  Fly   495 NEDEADEQPS 504
            |...|.|.|:
Zfish   433 NPIYASEMPT 442

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7183	NP_001262701.1	DUF4078	248..328	CDD:290039	31/81 (38%)
ccdc174	XP_021332539.1	DUF4078	227..300	CDD:315876	29/74 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170593607
Domainoid	1	1.000	72	1.000	Domainoid score	I9340
eggNOG	1	0.900	-	-		E1_28PWN
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	140	1.000	Inparanoid score	I4486
OMA	1	1.010	-	-		QHG52682
OrthoDB	1	1.010	-	-		D1585377at2759
OrthoFinder	1	1.000	-	-		FOG0007399
OrthoInspector	1	1.000	-	-		oto40432
orthoMCL	1	0.900	-	-		OOG6_104564
Panther	1	1.100	-	-	LDO	PTHR15885
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5389
SonicParanoid	1	1.000	-	-		X6283
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	14	13.800