Protein Alignment CG7183 and CCDC174

DIOPT Version :9

• Sequence 1: NP_001262701.1
• Gene: CG7183 / 42181
• FlyBaseID: FBgn0038583
• Length: 568
• Species: Drosophila melanogaster
• Sequence 2: NP_057558.3
• Gene: CCDC174 / 51244
• HGNCID: 28033
• Length: 467
• Species: Homo sapiens
• Alignment Length: 567
• Identity: 150/567 - (26%)
• Similarity: 241/567 - (42%)
• Gaps: 139/567 - (24%)

  Fly     1 MNDPNKAISVNLSSLLSLKAELLRKQHEVRVAKATKASAADFRPTKSAGNKEKS----SDQGYKK 61
            |:...|.:.|..|||:.|||||.|||.|.:..|..|.|....:|..:  ||:.|    .:.|...
Human     1 MDRRKKPLDVTASSLVDLKAELFRKQEEFKQEKLLKDSGVFGKPKTT--NKKPSIWSKQNVGVSN 63

  Fly    62 VASSDDGAKVYEAEDHAQLEKSRRILEAKSKFYDRMSRNGGSLNS--DDNCLVMFNRKKQEADRE 124
            .|..|...|:   |:...|:|:|..||.|:|.|::|:: |..::.  :|..||.|.:|..:..:|
Human    64 RAEKDAEQKI---EEQKTLDKAREKLEEKAKLYEKMTK-GDFIDEEVEDMYLVDFTQKIIDKRKE 124

  Fly   125 PEQCTQRRESRQRLSSSSSSSQDEEGHDDLE-----------VEYVDCLGRTRKCLRKDLKEAKR 178
            .|.....|:|::    :.....|||...:.|           |:|||.|||:|:|:||||.:...
Human   125 MEASGAHRDSQK----AGERDDDEENLPEGEIPPPQDPSEEWVDYVDSLGRSRRCMRKDLPDLLE 185

  Fly   179 RDKQLAESMPERLDQTKANWMINTKGSRELNSNHNSDDESFIGPRPTESVFSEALSTMTKHDEQR 243
            .||.|...:                               ||.|...:::.||.:    :.:.||
Human   186 MDKNLQGRL-------------------------------FISPANEKTLLSEDM----RKELQR 215

  Fly   244 MNWERKEQENFEKP--DVHYQDVFFDEARTHGVGYYAFSTDEDERRQQQLDLEKARQATKAKQMR 306
            ..||.:|:|..::|  .|||:|:..:|||..||||:||:.|::.|.:|...||..|:.|..::.:
Human   216 QQWEEEEREALKRPMGPVHYEDIRENEARQLGVGYFAFARDKELRNKQMKTLEMLREQTTDQRTK 280

  Fly   307 RDELRAQRDRLVADRVLAAKNRIRERNGLPPISEEDYLREEQQKKDELAKEEAELNRAEQERRAA 371
            |:.::.:|..::..|:...:.:..::      |:|....||.:..|.:.....|.......|.||
Human   281 RENIKEKRKAILEARLAKLRQKKMKK------SKEGGTEEENRDGDVIGPLPPEPEAVPTPRPAA 339

  Fly   372 IERKKEKEEAELEELRKE------HVRDWDKNKPGVRKLADSESAEPPEEEWKYKAERLPMSQEE 430
               :..|.|..::| ||:      |:|:||:.|               |..:.|
Human   340 ---QSSKVEVIVQE-RKDTKPGVPHIREWDRGK---------------EFSFGY----------- 374

  Fly   431 WNEKQ---RAQRHAEFAPMPEP-VPLKRSNFSSMPPPMVWNRAQEPQFHNFHSTKEEKKFQRRSY 491
            |:::|   ||:|..||||..:. |..||:.|||   ...|:|....|
Human   375 WSKRQSDLRAERDPEFAPPSDYFVGQKRTGFSS---SQAWSRPGPAQ------------------ 418

  Fly   492 SANNEDEADEQPSTSSRGMGAAIPPPAGLDDRAP--PAKKPKSQDDL 536
              ::..:..:|    |.|.......|....|..|  |....|:.||:
Human   419 --SDPGQCPDQ----SHGPSPEHTSPTPAPDNPPQAPTVTFKTLDDM 459

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG7183	NP_001262701.1	DUF4078	248..328	CDD:290039	26/81 (32%)
CCDC174	NP_057558.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	40..77		9/41 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	124..162		8/41 (20%)
		DUF4078	228..302	CDD:290039	24/73 (33%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	299..363		15/73 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	378..453		24/101 (24%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165157816
Domainoid	1	1.000	82	1.000	Domainoid score	I8462
eggNOG	1	0.900	-	-		E1_28PWN
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	147	1.000	Inparanoid score	I4424
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52682
OrthoDB	1	1.010	-	-		D1585377at2759
OrthoFinder	1	1.000	-	-		FOG0007399
OrthoInspector	1	1.000	-	-		oto88982
orthoMCL	1	0.900	-	-		OOG6_104564
Panther	1	1.100	-	-	LDO	PTHR15885
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5389
SonicParanoid	1	1.000	-	-		X6283
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.800