Protein Alignment RAB8A and Rab18

DIOPT Version :10

• Sequence 1: NP_005361.2
• Gene: RAB8A / 4218
• HGNCID: 7007
• Length: 207
• Species: Homo sapiens
• Sequence 2: NP_524744.2
• Gene: Rab18 / 44360
• FlyBaseID: FBgn0015794
• Length: 197
• Species: Drosophila melanogaster
• Alignment Length: 200
• Identity: 73/200 - (36%)
• Similarity: 120/200 - (60%)
• Gaps: 8/200 - (4%)

Human     6 DYLFKLLLIGDSGVGKTCVLFRFSEDAFNSTFISTIGIDFKIRTIELDGKRIKLQIWDTAGQERF 70
            |...|||:||:|||||:.::.||.|:.|:.....|||:|||.:.:::||...|:.:|||||.|||
  Fly     3 DRAIKLLVIGESGVGKSSLIRRFVENKFDQNHDVTIGMDFKSKVMQVDGIDYKVALWDTAGAERF 67

Human    71 RTITTAYYRGAMGIMLVYDITNEKSFDNIRNWIRNIEEHA-SADVEKMILGNKCDVNDKRQVSKE 134
            |::|.::||.|:|.:||||||:..|...:..|:..::.:: :.::..:::|||.|  ::|.|.:|
  Fly    68 RSLTPSFYRKALGAILVYDITSRDSLVKLETWLAELDSYSDNPNIAIIVVGNKID--EERVVDRE 130

Human   135 RGEKLALDYGIKFMETSAKANINVENAFFTLARDIKAKMDKKLEGNSPQGSNQGVKITPDQQKRS 199
            .|.|.|..:...|:|||||.:..|.:.|    :|:..|:......|:...| .|:.|..|:...:
  Fly   131 EGRKFARKHRALFIETSAKCDQFVSDVF----KDVVEKIVSSEYFNNGNAS-AGLDIASDRDLEA 190

Human   200 SFFRC 204
            |...|
  Fly   191 SASTC 195

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RAB8A	NP_005361.2	Rab8_Rab10_Rab13_like	6..172	CDD:206659	65/166 (39%)
		Switch 1. /evidence=ECO:0000250|UniProtKB:P62820	31..45		4/13 (31%)
		Switch 2. /evidence=ECO:0000250|UniProtKB:P62820	63..80		10/16 (63%)
Rab18	NP_524744.2	Rab18	6..165	CDD:206656	64/164 (39%)