Protein Alignment RAB8A and Rab7

DIOPT Version :10

• Sequence 1: NP_005361.2
• Gene: RAB8A / 4218
• HGNCID: 7007
• Length: 207
• Species: Homo sapiens
• Sequence 2: NP_524472.1
• Gene: Rab7 / 42841
• FlyBaseID: FBgn0015795
• Length: 207
• Species: Drosophila melanogaster
• Alignment Length: 197
• Identity: 72/197 - (36%)
• Similarity: 116/197 - (58%)
• Gaps: 11/197 - (5%)

Human     8 LFKLLLIGDSGVGKTCVLFRFSEDAFNSTFISTIGIDFKIRTIELDGKRIKLQIWDTAGQERFRT 72
            |.|::::|||.||||.::.::....|::.:.:|||.||..:.:.::.:.:.:|||||||||||::
  Fly     8 LLKVIILGDSSVGKTSLMNQYVNKRFSNQYKATIGADFCTKEVVVNDRVVTMQIWDTAGQERFQS 72

Human    73 ITTAYYRGAMGIMLVYDITNEKSFDNIRNWIRNIEEHAS-ADVEK---MILGNKCDVNDKRQVSK 133
            :..|:||||...:||||:|...||.|:.:|.......|| .|.:.   ::||||.|: |.||||.
  Fly    73 LGVAFYRGADCCVLVYDVTAPNSFKNLDSWRDEFLIQASPRDPDHFPFVVLGNKVDL-DNRQVST 136

Human   134 ERGEKLALDYG-IKFMETSAKANINVENAFFTLARD-IKAKMDKKLEGNSPQ----GSNQGVKIT 192
            .|.::...... |.:.|||||..||||.||..:|:: ::.:.:.::..:.|.    ||.......
  Fly   137 RRAQQWCQSKNDIPYYETSAKEGINVEMAFQVIAKNALELEAEAEVINDFPDQITLGSQNNRPGN 201

Human   193 PD 194
            ||
  Fly   202 PD 203

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RAB8A	NP_005361.2	Rab8_Rab10_Rab13_like	6..172	CDD:206659	67/169 (40%)
		Switch 1. /evidence=ECO:0000250|UniProtKB:P62820	31..45		4/13 (31%)
		Switch 2. /evidence=ECO:0000250|UniProtKB:P62820	63..80		10/16 (63%)
Rab7	NP_524472.1	Rab7	9..179	CDD:206655	66/170 (39%)