Protein Alignment RAB8A and Rab3

DIOPT Version :10

• Sequence 1: NP_005361.2
• Gene: RAB8A / 4218
• HGNCID: 7007
• Length: 207
• Species: Homo sapiens
• Sequence 2: NP_523687.1
• Gene: Rab3 / 36127
• FlyBaseID: FBgn0005586
• Length: 220
• Species: Drosophila melanogaster
• Alignment Length: 196
• Identity: 98/196 - (50%)
• Similarity: 145/196 - (73%)
• Gaps: 2/196 - (1%)

Human     3 KTYDYLFKLLLIGDSGVGKTCVLFRFSEDAFNSTFISTIGIDFKIRTIELDGKRIKLQIWDTAGQ 67
            :.:||:||||:||:|.||||..|||:::|:|.|.|:||:|||||::|:....||:||||||||||
  Fly    16 QNFDYMFKLLIIGNSSVGKTSFLFRYADDSFTSAFVSTVGIDFKVKTVFRHDKRVKLQIWDTAGQ 80

Human    68 ERFRTITTAYYRGAMGIMLVYDITNEKSFDNIRNWIRNIEEHASADVEKMILGNKCDVNDKRQVS 132
            ||:|||||||||||||.:|:||:|||.||:::::|:..|:.::..:.:.:::|||||:.|:|.:|
  Fly    81 ERYRTITTAYYRGAMGFILMYDVTNEDSFNSVQDWVTQIKTYSWDNAQVILVGNKCDMEDQRVIS 145

Human   133 KERGEKLALDYGIKFMETSAKANINVENAFFTLARDIKAKMDKKLEGNSP--QGSNQGVKITPDQ 195
            .|||.:||...|::|.|||||.|:||:..|..|...|..||.:.|:.:..  .|..:|.::|...
  Fly   146 FERGRQLADQLGVEFFETSAKENVNVKAVFERLVDIICDKMSESLDADPTLVGGGQKGQRLTDQP 210

Human   196 Q 196
            |
  Fly   211 Q 211

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RAB8A	NP_005361.2	Rab8_Rab10_Rab13_like	6..172	CDD:206659	91/165 (55%)
		Switch 1. /evidence=ECO:0000250|UniProtKB:P62820	31..45		8/13 (62%)
		Switch 2. /evidence=ECO:0000250|UniProtKB:P62820	63..80		15/16 (94%)
Rab3	NP_523687.1	Rab3	21..185	CDD:206657	89/163 (55%)