Protein Alignment RAB8A and Rab5

DIOPT Version :10

• Sequence 1: NP_005361.2
• Gene: RAB8A / 4218
• HGNCID: 7007
• Length: 207
• Species: Homo sapiens
• Sequence 2: NP_523457.1
• Gene: Rab5 / 33418
• FlyBaseID: FBgn0014010
• Length: 219
• Species: Drosophila melanogaster
• Alignment Length: 185
• Identity: 72/185 - (38%)
• Similarity: 111/185 - (60%)
• Gaps: 9/185 - (4%)

Human     9 FKLLLIGDSGVGKTCVLFRFSEDAFNSTFISTIGIDFKIRTIELDGKRIKLQIWDTAGQERFRTI 73
            |||:|:|:|.|||:.::.||.:..|:....||||..|..:||.::...:|.:|||||||||:.::
  Fly    30 FKLVLLGESAVGKSSLVLRFVKGQFHEYQESTIGAAFLTQTICIEDTVVKFEIWDTAGQERYHSL 94

Human    74 TTAYYRGAMGIMLVYDITNEKSFDNIRNWIRNIEEHASADVEKMILGNKCDVNDKRQVSKERGEK 138
            ...|||||...::||||.|:.||...:.|::.:.:.||.::...:.|||.|:::.|.|..:..::
  Fly    95 APMYYRGAQAAIVVYDIQNQDSFQRAKTWVKELHKQASPNIVIALAGNKADLSNIRVVEFDEAKQ 159

Human   139 LALDYGIKFMETSAKANINVENAFFTLARDIKAKMDKKLEGNSPQGSNQGVKITP 193
            .|.:.|:.|||||||..:||.:.|..:|        |||..|. ..:|||..|.|
  Fly   160 YAEENGLLFMETSAKTGMNVNDIFLAIA--------KKLPKND-GANNQGTSIRP 205

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RAB8A	NP_005361.2	Rab8_Rab10_Rab13_like	6..172	CDD:206659	63/162 (39%)
		Switch 1. /evidence=ECO:0000250|UniProtKB:P62820	31..45		5/13 (38%)
		Switch 2. /evidence=ECO:0000250|UniProtKB:P62820	63..80		9/16 (56%)
Rab5	NP_523457.1	Rab5_related	29..191	CDD:206653	65/168 (39%)