Protein Alignment RAB8A and Rab35

DIOPT Version :10

• Sequence 1: NP_005361.2
• Gene: RAB8A / 4218
• HGNCID: 7007
• Length: 207
• Species: Homo sapiens
• Sequence 2: NP_608373.1
• Gene: Rab35 / 33014
• FlyBaseID: FBgn0031090
• Length: 201
• Species: Drosophila melanogaster
• Alignment Length: 201
• Identity: 98/201 - (48%)
• Similarity: 141/201 - (70%)
• Gaps: 17/201 - (8%)

Human     1 MAKTYDYLFKLLLIGDSGVGKTCVLFRFSEDAFNSTFISTIGIDFKIRTIELDGKRIKLQIWDTA 65
            ||:.:|:|||||:||||||||:.:|.|||:|.|:.::|:|||:||||||::::|.|:||||||||
  Fly     1 MARGFDHLFKLLIIGDSGVGKSSLLIRFSDDTFSGSYITTIGVDFKIRTVDIEGMRVKLQIWDTA 65

Human    66 GQERFRTITTAYYRGAMGIMLVYDITNEKSFDNIRNWIRNIEEHASADVEKMILGNKCDVNDKRQ 130
            |||||||||:.||||..|:::|||:||.:||.|:|.|:..|:.:... |:|:::|||.|..|::.
  Fly    66 GQERFRTITSTYYRGTHGVIVVYDVTNGESFANVRRWLEEIQNNCDV-VKKVLVGNKNDDPDRKV 129

Human   131 VSKERGEKLALDYGIKFMETSAKANINVENAFFTLARDIKAKMDKKLEGN-------------SP 182
            |..|..::.|....|:..|||||.||||||.|.::.|.:   :|.||..:             :|
  Fly   130 VITEDAQRFAKQMDIELFETSAKDNINVENMFLSITRQV---LDHKLRTSPNEQQKDTLHLKPNP 191

Human   183 QGSNQG 188
            :||..|
  Fly   192 KGSKGG 197

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RAB8A	NP_005361.2	Rab8_Rab10_Rab13_like	6..172	CDD:206659	89/165 (54%)
		Switch 1. /evidence=ECO:0000250|UniProtKB:P62820	31..45		6/13 (46%)
		Switch 2. /evidence=ECO:0000250|UniProtKB:P62820	63..80		14/16 (88%)
Rab35	NP_608373.1	Rab35	3..201	CDD:133310	96/199 (48%)