Protein Alignment RAB8A and Rab27

DIOPT Version :10

• Sequence 1: NP_005361.2
• Gene: RAB8A / 4218
• HGNCID: 7007
• Length: 207
• Species: Homo sapiens
• Sequence 2: NP_726743.1
• Gene: Rab27 / 31103
• FlyBaseID: FBgn0025382
• Length: 236
• Species: Drosophila melanogaster
• Alignment Length: 170
• Identity: 74/170 - (43%)
• Similarity: 116/170 - (68%)
• Gaps: 5/170 - (2%)

Human    10 KLLLIGDSGVGKTCVLFRFSEDAFNSTFISTIGIDFKIRTIELDGK----RIKLQIWDTAGQERF 70
            :.|::|||||||||:|:::::..|::.||||:||||:.:.:..:.:    ||.||||||||||||
  Fly    19 QFLVLGDSGVGKTCLLYQYTDGRFHTQFISTVGIDFREKRLLYNSRGRRHRIHLQIWDTAGQERF 83

Human    71 RTITTAYYRGAMGIMLVYDITNEKSFDNIRNWIRNIEEHA-SADVEKMILGNKCDVNDKRQVSKE 134
            |::|||:||.|||.:|::|:|:||||....||:..:..|| |.|.:.::.|||||:...|.||::
  Fly    84 RSLTTAFYRDAMGFLLIFDLTSEKSFLETANWLSQLRTHAYSEDPDVVLCGNKCDLLQLRVVSRD 148

Human   135 RGEKLALDYGIKFMETSAKANINVENAFFTLARDIKAKMD 174
            :...|...|.:.::||||....||:.|...|...:..:::
  Fly   149 QVAALCRRYRLPYIETSACTGANVKEAVELLVGRVMERIE 188

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RAB8A	NP_005361.2	Rab8_Rab10_Rab13_like	6..172	CDD:206659	74/166 (45%)
		Switch 1. /evidence=ECO:0000250|UniProtKB:P62820	31..45		7/13 (54%)
		Switch 2. /evidence=ECO:0000250|UniProtKB:P62820	63..80		13/16 (81%)
Rab27	NP_726743.1	P-loop containing Nucleoside Triphosphate Hydrolases	19..187	CDD:476819	74/167 (44%)