DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7985 and hexd

DIOPT Version :9

Sequence 1:	NP_001262699.1	Gene:	CG7985 / 42178	FlyBaseID:	FBgn0028499	Length:	708	Species:	Drosophila melanogaster
Sequence 2:	XP_012827188.1	Gene:	hexd / 548664	XenbaseID:	XB-GENE-5729873	Length:	485	Species:	Xenopus tropicalis

Alignment Length:	520	Identity:	194/520 - (37%)
Similarity:	270/520 - (51%)	Gaps:	73/520 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   182 PDG--PRAPAERLVHLDLKGAPPKLSFLKQLLPVLRALGATGLLIEYEDMFPYSGVLQPLAAHNA 244
            ||.  |.:|.. ||||||||||||:|:|.::||:..|||||||||||||.|||.|.|.||.|.:|
Frog    14 PDRAVPASPLV-LVHLDLKGAPPKVSYLAEVLPLFSALGATGLLIEYEDTFPYYGELLPLRAPHA 77

  Fly   245 YKEDELRDFLECAALHGLSVMPLVQTFGHMEYVLKLSGFEQLRELAESPQSICPSQPQSMALLEQ 309
            |...|:|:.|..|....|.|:||||||||||:|||...|..|||:...|.::.|.:.||:.|::.
Frog    78 YSPQEIREILRLAQSCQLEVIPLVQTFGHMEFVLKHKEFAHLREVEAFPNTLNPHKEQSLPLVQA 142

  Fly   310 MLTQVIELHSQCLGQATPATNVPVARIRFTHIHIGCDEVQRMGECTTCRQRLRS------ELFLS 368
            |:.||:|||             |.||    .:|:|.|||..:||....::.:.:      |:||.
Frog   143 MIGQVMELH-------------PDAR----WLHVGSDEVYCLGEGNESKEIMANTQITVEEIFLH 190

  Fly   369 HVVSMAHFIRRQWPHLGVVIWDDQLRSMSLSELQHSQVGSYVEPMVWVYASDIYRFIQPQLWDTY 433
            |:.|:...:...:|.:..:.|||.:|:.:...|..|.|...||.|:|.|:.|:         |..
Frog   191 HLKSVTSHVASTFPGVRPIAWDDMIRAANEQALTESGVAPLVELMLWDYSPDL---------DVD 246

  Fly   434 AKV----------FPSAWTASAFKGAFGESLLVPPLQHHLENNIRWLAVIAKEGGRFSKG-LRGL 487
            .||          |...|.|||||||.|....:..:.|||.||.:||    |..|:..|. |:|:
Frog   247 NKVATVAKYKQSGFQKIWFASAFKGATGVREQLTSINHHLGNNSQWL----KVAGKIPKELLQGI 307

  Fly   488 ALTGWQRYDHFAVLCELLPVGIPSLMTSLSTVSKGYFSTNPRDNELLRVLQCVFQPDSRRSGRPW 552
            |||||||||||:||||||||.:||:...|..:..|.:|.        :|::.|      :|....
Frog   308 ALTGWQRYDHFSVLCELLPVALPSVAVCLQFLKHGEYSD--------QVMEQV------KSFLGM 358

  Fly   553 LELHPNAHHSQLFAVC--NYPGHLVFKYALRLFDKL-AEIRLYLQQTRDQSAWLSDYNVRHNFSS 614
            .||      ..|.:.|  ::||..||....:|...| .|:...|.:.|..:.|.|.|:.|.|..|
Frog   359 TEL------ENLASKCSGSFPGSKVFSLITQLMCNLRPELNELLGENRYVAGWFSPYHRRINVIS 417

  Fly   615 PLRVRELTARTPMLIEELRAMAREAQQLLWEVYDEYTVTEFVEQHIYPTIEALQRQLARAEMLLQ 679
            ||.|:|:...|..|:...:.:..|.|..|.::|....|.|::|.::.|....|::........||
Frog   418 PLMVQEIQPATTSLMSRWQTLHDELQNELLQIYPPSAVAEWMEVNVLPWYLQLKKLAEELNAALQ 482

Fly 680 679
Frog 483 482

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7985	NP_001262699.1	DUF737	78..>170	CDD:283062
CG7985	NP_001262699.1	GH20_GcnA-like	191..517	CDD:119335	148/342 (43%)
hexd	XP_012827188.1	GH20_GcnA-like	25..337	CDD:119335	148/341 (43%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	290	1.000	Inparanoid score	I2743
OMA	1	1.010	-	-		QHG46370
OrthoDB	1	1.010	-	-		D1021041at2759
OrthoFinder	1	1.000	-	-		FOG0003694
OrthoInspector	1	1.000	-	-		otm47513
Panther	1	1.100	-	-	LDO	PTHR21040
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R7251
SonicParanoid	1	1.000	-	-		X2558
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	10.110