DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7985 and zgc:113333

DIOPT Version :9

Sequence 1:	NP_001262699.1	Gene:	CG7985 / 42178	FlyBaseID:	FBgn0028499	Length:	708	Species:	Drosophila melanogaster
Sequence 2:	XP_005163932.1	Gene:	zgc:113333 / 541364	ZFINID:	ZDB-GENE-050320-57	Length:	573	Species:	Danio rerio

Alignment Length:	600	Identity:	181/600 - (30%)
Similarity:	298/600 - (49%)	Gaps:	76/600 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   101 GNVRSLRPTQAKKAPLPMSESFLFEQERLKILEQQQRQRNAGMEELNANAEDERMLSSAERQTQY 165
            |:|:|    :::|....:.....:..:|:.:::..:.:::....|.....|.|......::|.|.
Zfish    28 GSVKS----KSEKTHQIIQGGNFWASQRIPLIKVVENKQDTVKTEQQPKVEQEESEKIQKKQEQL 88

  Fly   166 EHELQRMGVPVVAGIGPDGPRAPAERLVHLDLKGAPPKLSFLKQLLPVLRALGATGLLIEYEDMF 230
            :.|:.....|:              ::|||||||||||:.:|:||.|:|.:|||.|:|:||||||
Zfish    89 KPEVPEKTDPL--------------KIVHLDLKGAPPKVKYLEQLFPLLSSLGANGILLEYEDMF 139

  Fly   231 PYSGVLQPLAAHNAYKEDELRDFLECAALHGLSVMPLVQTFGHMEYVLKLSGFEQLRELAESPQS 295
            ||.|.|:.|.:..||..:::.:....|..|.|.::||||.|||||:|||...:.:|||:...|.|
Zfish   140 PYEGDLEILKSSFAYSPEDIEEIKSLAKRHNLELIPLVQVFGHMEFVLKHEKYFKLREVETFPNS 204

  Fly   296 ICPSQPQSMALLEQMLTQVIELHSQCLGQATPATNVPVARIRFTHIHIGCDEVQRMGECTTCRQR 360
            :......||.|::.||.||::.|             |.||    ..|||.|||:.:||....::.
Zfish   205 LNSLAQGSMELVQNMLMQVMKKH-------------PEAR----WFHIGADEVRGLGESEDSKRW 252

  Fly   361 LRS------ELFLSHVVSMAHFIRRQWPHLGVVIWDDQLRSMSLSELQHSQVGSYVEPMVWVY-- 417
            |.:      :|:|:||.::|.|:.:|...:.:::|||..|..|...::.|.:.....||:|.|
Zfish   253 LEANNGDMGKLYLNHVTAVAKFMTKQKQRIKLILWDDMFRKFSPDTIKESGLQDLASPMIWNYHA 317

  Fly   418 ---ASDIYRFIQPQLWDTYAKV-FPSAWTASAFKGAFGESLLVPPLQHHLENNIRWLAVIAKEGG 478
               ..||.::|     ..|.:. |...|.|||||||.|...:..|:.|||:|:|:|..|||....
Zfish   318 NLNVKDIGKYI-----SKYEQAGFRGVWFASAFKGASGIDQIWTPIDHHLKNHIQWQEVIASMPQ 377

  Fly   479 RFSKGLRGLALTGWQRYDHFAVLCELLPVGIPSLMTSLSTVSKGYFSTNPRDNELLRVLQCVFQP 543
            ..|...:|:||||||||:|..||||||||.||||...|.|:..|.|:...: .|:.|:|.|..|
Zfish   378 YKSVRFQGIALTGWQRYEHHTVLCELLPVAIPSLTVCLQTLKYGAFNAKAQ-GEVQRMLGCEIQ- 440

  Fly   544 DSRRSGRPWLELHPNAHHSQLFAVC---NYPGHLVFKYALRLFDKLAEIRLYLQQTRDQSAWLSD 605
                       |..|.        |   ::||..:::...::...|....:.|:|........|.
Zfish   441 -----------LEKND--------CKGASFPGSDIYEMVKKIHTNLQSSIINLKQNYHVKGSFSF 486

  Fly   606 YNVRHNFSSPLRVRELTARTPMLIEELRAMAREAQQLLWEVYDEYTVTEFVEQHIYPTIEALQRQ 670
            |:.:.||::|..:.........:::|..:.....::.:..::...|:.|::|:::...||.|...
Zfish   487 YHRKRNFANPRNLGFFKDDLKKMMDEWDSFLLTFRESMEAIFYPDTLEEWLEENVNEHIETLHNM 551

  Fly   671 LARAEMLLQRRTWPQ 685
            :...|.:::....|:
Zfish   552 VVDVERIIKLNGQPK 566

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7985	NP_001262699.1	DUF737	78..>170	CDD:283062	11/68 (16%)
CG7985	NP_001262699.1	GH20_GcnA-like	191..517	CDD:119335	138/337 (41%)
zgc:113333	XP_005163932.1	GH20_GcnA-like	100..416	CDD:119335	138/337 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170580227
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	260	1.000	Inparanoid score	I3113
OMA	1	1.010	-	-		QHG46370
OrthoDB	1	1.010	-	-		D1021041at2759
OrthoFinder	1	1.000	-	-		FOG0003694
OrthoInspector	1	1.000	-	-		otm26232
orthoMCL	1	0.900	-	-		OOG6_105415
Panther	1	1.100	-	-	O	PTHR21040
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R7251
SonicParanoid	1	1.000	-	-		X2558
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	13	12.900