DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7985 and HEXD

DIOPT Version :9

Sequence 1:	NP_001262699.1	Gene:	CG7985 / 42178	FlyBaseID:	FBgn0028499	Length:	708	Species:	Drosophila melanogaster
Sequence 2:	NP_775891.2	Gene:	HEXD / 284004	HGNCID:	26307	Length:	585	Species:	Homo sapiens

Alignment Length:	396	Identity:	166/396 - (41%)
Similarity:	228/396 - (57%)	Gaps:	60/396 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   191 RLVHLDLKGAPPKLSFLKQLLPVLRALGATGLLIEYEDMFPYSGVLQPLAAHNAYKEDELRDFLE 255
            |||||||||||||:|:|.::.|:.|||||.||||||||||||.|.|:.|.|..||...|:::.|.
Human    10 RLVHLDLKGAPPKVSYLSEIFPLFRALGANGLLIEYEDMFPYEGPLRLLRAKYAYSPSEIKEILH 74

  Fly   256 CAALHGLSVMPLVQTFGHMEYVLKLSGFEQLRELAESPQSICPSQPQSMALLEQMLTQVIELHSQ 320
            .|.|:.|.|:||||||||||:|||.:.|..|||:...|.::.|.:.:|:||:..|:.||:|||
Human    75 LAGLNELEVIPLVQTFGHMEFVLKHTAFAHLREVGSFPCTLNPHEAESLALVGAMIDQVLELH-- 137

  Fly   321 CLGQATPATNVPVARIRFTHIHIGCDEVQRMGECTTCRQRLRSE------LFLSHVVSMAHFIRR 379
                       |.|:    .:|||||||..:||....|:.|:.|      |.|||:.::|..::.
Human   138 -----------PGAQ----RLHIGCDEVYYLGEGEASRRWLQQEQNSTGKLCLSHMRAVASGVKA 187

  Fly   380 QWPHLGVVIWDDQLRSMSLSELQHSQVGSYVEPMVWVYASDIYRFIQPQLWDTYAKV-------- 436
            :.|.:..::|||.||.:...:|..|.|...|||::|.|.:|:         |.:.||
Human   188 RRPSVTPLVWDDMLRDLPEDQLAASGVPQLVEPVLWDYTADL---------DVHGKVLLMQKYRR 243

  Fly   437 --FPSAWTASAFKGAFGESLLVPPLQHHLENNIRWLAVIAKEGGRFSKGLRGLALTGWQRYDHFA 499
              ||..|.|||||||.|.|..|||::|||.|:::||.|   .|...:..|:|:.|||||||||::
Human   244 CGFPQLWAASAFKGATGPSQAVPPVEHHLRNHVQWLQV---AGSGPTDSLQGIILTGWQRYDHYS 305

  Fly   500 VLCELLPVGIPSLMTSLSTVSKGYFSTNPRDN-ELLRVLQCVFQPDSRRSG-------------- 549
            |||||||.|:|||...|..:.:|.|..:.:.. |.|..:..:.:.|..|..
Human   306 VLCELLPAGVPSLAACLQLLLRGGFDEDVKAKVENLLGISSLEKTDPVRQAPCSPPCPLLPLPFP 370

  Fly   550 RPWLEL 555
            |||.:|
Human   371 RPWRQL 376

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7985	NP_001262699.1	DUF737	78..>170	CDD:283062
CG7985	NP_001262699.1	GH20_GcnA-like	191..517	CDD:119335	155/341 (45%)
HEXD	NP_775891.2	GH20_GcnA-like	9..323	CDD:119335	155/341 (45%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146782
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_arCOG07452
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H68120
Inparanoid	1	1.050	308	1.000	Inparanoid score	I2626
Isobase	1	0.950	-	0	Normalized mean entropy	S7178
OMA	1	1.010	-	-		QHG46370
OrthoDB	1	1.010	-	-		D1021041at2759
OrthoFinder	1	1.000	-	-		FOG0003694
OrthoInspector	1	1.000	-	-		oto88432
orthoMCL	1	0.900	-	-		OOG6_105415
Panther	1	1.100	-	-	LDO	PTHR21040
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R7251
SonicParanoid	1	1.000	-	-		X2558
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.750