DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7985 and hex-4

DIOPT Version :9

Sequence 1:	NP_001262699.1	Gene:	CG7985 / 42178	FlyBaseID:	FBgn0028499	Length:	708	Species:	Drosophila melanogaster
Sequence 2:	NP_740792.3	Gene:	hex-4 / 245995	WormBaseID:	WBGene00021766	Length:	491	Species:	Caenorhabditis elegans

Alignment Length:	516	Identity:	148/516 - (28%)
Similarity:	241/516 - (46%)	Gaps:	84/516 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   179 GIGPDGPRAPAERLVHLDLKGAPPKLSFLKQLLPVLRALGATGLLIEYEDMFPYSGVLQPLAAHN 243
            ||.|...|.....:||||||||||::.:|.:...:|......|:||||||||||||.::.:....
Worm    40 GIDPRKTRQFKNIIVHLDLKGAPPRVEYLIEFFKLLSKHHVDGILIEYEDMFPYSGDIEEIRRDL 104

  Fly   244 AYKEDELRDFLECAALHGLSVMPLVQTFGHMEYVLKLSGFEQLRELAESPQSICPSQPQSMALLE 308
            .|.|:::|..::.|.:|.|.|:||:|:|||:|:|||.|.|..|.|......:||.|..:|:.:::
Worm   105 HYSENDIRRIIQAAEVHNLEVIPLIQSFGHLEFVLKKSKFMGLSEDLIDLNTICISDSKSIDIVK 169

  Fly   309 QMLTQVIELHSQCLGQATPATNVPVARIRFTHIHIGCDEVQRMGECTTCRQRL------RSELFL 367
            ||:.|:..||...                 |.||||.||...:.|...|.:|:      :|:|.|
Worm   170 QMIEQIRRLHPNS-----------------TRIHIGADEAYHVAEDQRCIERMEKESIGKSDLKL 217

  Fly   368 SHVVSMAHFIRRQWPHLGVVIWDDQLRSMSLSELQHSQVGSYVEPMVWVYASDIYR--FIQPQLW 430
            .|:..:..|.|.......|..|:|.....|...::.|::..::.|:||.|.:|:..  :....|:
Worm   218 EHIAKIGKFARENAGFETVFAWNDMFDKESEETIRKSKINKFIVPVVWGYRTDVTENGYFPDGLF 282

  Fly   431 DTYAKVFPSAWTASAFKGAFGESLLVPPLQHHLENNIRWLAVIAKEGGRFSKGLRGLALTGWQRY 495
            :....||...:.|||||||.|.......:..:|||...::.::.......::.:.|:.:|||.|:
Worm   283 ERIFNVFDRFYVASAFKGADGARQQFSNISRYLENQKSYVNLMDLHKNAAAQKVDGIFVTGWSRF 347

  Fly   496 DHFAVLCELLPVGIPSLMTSLSTVSKGYFSTNPRDNELLRVLQCVFQPDSRRSGRPWLELHPNAH 560
            :||..|||||||.||||:..|.     |.:....:.:..|.::...:.::||..|..|.  .:..
Worm   348 NHFNALCELLPVAIPSLIVDLF-----YLNYQLTEKDAWRAMKSSLECENRRHLRGILA--ESTV 405

  Fly   561 HSQLFAVCNYPGHLVFKYALRLFDKLAEIRLY----LQQTRDQSAWLSDYNVRHNFSSPLRVREL 621
            |.     |.:||..||:..:..:.:..:.|::    .|.:.|..|
Worm   406 HG-----CKFPGADVFEIIMHDWKRAVDRRIFGKPDQQPSPDSEA-------------------- 445

  Fly   622 TARTPMLIEELRAMAREA-QQLLW-----EVYDEYTVTEFVEQHIYPTIEALQRQLARAEM 676
                   ||.|:.:.:.. |.:|:     ||:::|.       |.|.::.|   |..|.|:
Worm   446 -------IEILKNLKKSLNQSILYKTDADEVFNQYL-------HDYHSLIA---QNTRTEI 489

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7985	NP_001262699.1	DUF737	78..>170	CDD:283062
CG7985	NP_001262699.1	GH20_GcnA-like	191..517	CDD:119335	113/333 (34%)
hex-4	NP_740792.3	GH20_GcnA-like	51..368	CDD:119335	113/333 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160159020
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_arCOG07452
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S7178
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1021041at2759
OrthoFinder	1	1.000	-	-		FOG0003694
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_105415
Panther	1	1.100	-	-	O	PTHR21040
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R7251
SonicParanoid	1	1.000	-	-		X2558
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	12	11.690