DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG7985 and Hexdc

DIOPT Version :9

Sequence 1:NP_001262699.1 Gene:CG7985 / 42178 FlyBaseID:FBgn0028499 Length:708 Species:Drosophila melanogaster
Sequence 2:NP_001139545.1 Gene:Hexdc / 238023 MGIID:3605542 Length:559 Species:Mus musculus


Alignment Length:579 Identity:196/579 - (33%)
Similarity:288/579 - (49%) Gaps:119/579 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly   191 RLVHLDLKGAPPKLSFLKQLLPVLRALGATGLLIEYEDMFPYSGVLQPLAAHNAYKEDELRDFLE 255
            |||||||||||||:|:|.::.|:..||||.||||||||||||.|.|:.|.|.:||...|:.:.|.
Mouse    10 RLVHLDLKGAPPKVSYLSEVFPLFHALGANGLLIEYEDMFPYEGHLRLLRAKHAYSPSEVTEILR 74

  Fly   256 CAALHGLSVMPLVQTFGHMEYVLKLSGFEQLRELAESPQSICPSQPQSMALLEQMLTQVIELHSQ 320
            .|.|..|.|:||||||||||:|||.:.|..|||:|..|.::.|.:.:|:||::.|:.|::|||..
Mouse    75 LARLSELEVIPLVQTFGHMEFVLKHAAFAHLREVALFPNTLNPHEAESLALVQAMIDQILELHRD 139

  Fly   321 CLGQATPATNVPVARIRFTHIHIGCDEVQRMGECTTCRQRLRSE------LFLSHVVSMAHFIRR 379
                           :|:  :|||||||..:||..|.:|.|:.|      |.|||:.::|..:..
Mouse   140 ---------------VRW--LHIGCDEVYYLGEGETSKQWLQQEQNSHAKLCLSHMQAVASHVLT 187

  Fly   380 QWPHLGVVIWDDQLRSMSLSELQHSQVGSYVEPMVWVYASDIYRFIQPQLWDTYAKV-------- 436
            |.|.:..::|||.||.:...:|:.|.|...|||::|.|.:|:         |.:.||        
Mouse   188 QHPGVTPLVWDDMLRDIPQEQLKASGVPQLVEPVLWDYGADL---------DVHGKVFLIGKYQE 243

  Fly   437 --FPSAWTASAFKGAFGESLLVPPLQHHLENNIRWLAVIAKEGGRFSKGLRGLALTGWQRYDHFA 499
              |...|.|||||||.|.|..:||::||:.|:..||.|   .|......|:|:.||||||||||:
Mouse   244 CGFQRLWAASAFKGATGASQALPPVEHHIRNHELWLQV---AGSGPKDALQGIILTGWQRYDHFS 305

  Fly   500 VLCELLPVGIPSLMTSLSTVSKG---YFSTNPRDNELLRVLQCVFQPDSRR-------------- 547
            |||||||||||||...|.::..|   |.::.|..    ..:.||.:|.:..              
Mouse   306 VLCELLPVGIPSLAACLQSLVHGALDYSASEPGH----LYMDCVVRPGAPADCAATTFHMFTGKQ 366

  Fly   548 ----SGRPWLELHPNAHHSQLFAV-----C----------------------------------- 568
                :|.| .:..|.||.:|...|     |                                   
Mouse   367 PPGLAGAP-QDAVPFAHSTQRSGVLSEHFCLWTVSGGFAEDVRLRAERFLGVSSLEIADTVSEGA 430

  Fly   569 -NYPGH----LVFKYALRLFDKLAEIRLYLQQTRDQSAWLSDYNVRHNFSSPLRVRELTARTPML 628
             ::||.    ||.:.:|.|   .:.:...|::.|..:.|.|.|:.|.....|:.::.:......|
Mouse   431 GSFPGSDIHALVTQISLHL---RSSVDTLLERNRYVTGWFSPYHRRRKLVHPVMIQHIQPEALSL 492

  Fly   629 IEELRAMAREAQQLLWEVYDEYTVTEFVEQHIYPTIEALQRQLARAEMLLQRRTWPQRP 687
            :.....:.::.:..|..|:...|:.|::|:::.|:::.||..|........|:..|..|
Mouse   493 LSRWNNLVQQLEVALQPVFYPDTIEEWLEENVLPSLQRLQDLLQDLGEAAARQPPPTSP 551

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG7985NP_001262699.1 DUF737 78..>170 CDD:283062
GH20_GcnA-like 191..517 CDD:119335 155/341 (45%)
HexdcNP_001139545.1 GH20_GcnA-like 9..323 CDD:119335 155/341 (45%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167836737
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_arCOG07452
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H68120
Inparanoid 1 1.050 305 1.000 Inparanoid score I2618
Isobase 1 0.950 - 0 Normalized mean entropy S7178
OMA 1 1.010 - - QHG46370
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0003694
OrthoInspector 1 1.000 - - oto92003
orthoMCL 1 0.900 - - OOG6_105415
Panther 1 1.100 - - LDO PTHR21040
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R7251
SonicParanoid 1 1.000 - - X2558
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
1615.740

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