Protein Alignment Arp5 and ACTR5

DIOPT Version :10

• Sequence 1: NP_650684.1
• Gene: Arp5 / 42173
• FlyBaseID: FBgn0038576
• Length: 648
• Species: Drosophila melanogaster
• Sequence 2: NP_079131.3
• Gene: ACTR5 / 79913
• HGNCID: 14671
• Length: 607
• Species: Homo sapiens
• Alignment Length: 657
• Identity: 223/657 - (33%)
• Similarity: 353/657 - (53%)
• Gaps: 124/657 - (18%)

  Fly     7 LVIDNGSYECRVGWS-----DSKEPDLRFRNVLTKPRKDRKKEAAASEGSASQTTVEQSAEIQVG 66
            ||:||||::.|.||:     ...||.|:||.|..:.|       ..:.|::..         |||
Human    33 LVLDNGSFQVRAGWACPGQDPGPEPRLQFRAVCARGR-------GGARGASGP---------QVG 81

  Fly    67 NDITNIEAVRAHLKSPFERNVITNWNHQEQIFDYIFTKMGFDGQDKIDHPIILTEALANPNFCRQ 131
            |.:.::|.:|..|:|||:|||..|...||.:.||.|..:|...|..:||||:||||:.||.:.||
Human    82 NALGSLEPLRWMLRSPFDRNVPVNLELQELLLDYSFQHLGVSSQGCVDHPIVLTEAVCNPLYSRQ 146

  Fly   132 QMNELLFECYGIPSVSYGIDALYSWKHHQQKQKNISDALIISFGYSTTHVIPVLDGKLQLEHVRR 196
            .|:||||||||||.|:||||:|:|:.|::.| .::...||||.||..|||:|:|:|:|..::.:|
Human   147 MMSELLFECYGIPKVAYGIDSLFSFYHNKPK-NSMCSGLIISSGYQCTHVLPILEGRLDAKNCKR 210

  Fly   197 LNVGGYHIITYLFRLMQMKYPVHLNAITISRMEKLVHEHCHIAVDYKEELVQWAQMDYYDEHIMK 261
            :|:||.....||.||:|:|||.||.|||:||||:::|||.:||.||.|||.:|...|||:.::.|
Human   211 INLGGSQAAGYLQRLLQLKYPGHLAAITLSRMEEILHEHSYIAEDYVEELHKWRCPDYYENNVHK 275

  Fly   262 IQLPYNAVTATNAMLTAEQKQEKRRELAHRLLDIKKNREQEKLREDEQQLFVYNKLRQLYEQKKL 326
            :|||::: ....:.||:|:|||:|::...||.::...|.:|||:.|:::|.....:::|.|..::
Human   276 MQLPFSS-KLLGSTLTSEEKQERRQQQLRRLQELNARRREEKLQLDQERLDRLLYVQELLEDGQM 339

  Fly   327 DKFERALQQQQIGTLEDLDSLIATINSRIKRAQERAQSGPRPSKQQERLNKMPKPPEGMSQADWL 391
            |:|.:||.:..:.:.|:|.|.|..::..:::|:::.... ..:.:.:.::..|:.|:       |
Human   340 DQFHKALIELNMDSPEELQSYIQKLSIAVEQAKQKILQA-EVNLEVDVVDSKPETPD-------L 396

  Fly   392 AELQGKREKILGRKQARQQQRSEQAKRHTHAAQERMRIISSLAKNEKRRKANGEEEDDGFGMNDN 456
            .:|:...|
Human   397 EQLEPSLE--------------------------------------------------------- 404

  Fly   457 DWDVYKRINRYNDDSDSDADNEKLMQFDKILNHYDANTDG-----NSNVPPQSAAENYQLHFGVE 516
                               |.|.:..||.:   :...|.|     .:..|..:.|..:||..|.|
Human   405 -------------------DVESMNDFDPL---FSEETPGVEKPVTTVQPVFNLAAYHQLFVGTE 447

  Fly   517 NIRVPEVLFQPSMIGCSEAGLAELIAFVLKLFPAAEQQRLVEHVYLTGGCAQFKGLKERLIKELM 581
            .||.||::||||:||..:||:||.:.::|..:|...|:.||::|:||||...:.|:|.|:.|||:
Human   448 RIRAPEIIFQPSLIGEEQAGIAETLQYILDRYPKDIQEMLVQNVFLTGGNTMYPGMKARMEKELL 512

  Fly   582 EMRPFQSKFAIYESDEPTLSAWLG----ACVHAGEPTFGQTLTTRQDHQEHGREFFREHTASNIF 642
            |||||:|.|.:..:..|.|.||.|    |..|..:   .:...||::::|.|.|:.:||.||||:
Human   513 EMRPFRSSFQVQLASNPVLDAWYGARDWALNHLDD---NEVWITRKEYEEKGGEYLKEHCASNIY 574

  Fly   643 YP--TPK 647
            .|  .||
Human   575 VPIRLPK 581

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Arp5	NP_650684.1	ASKHA_NBD_Arp5	6..>285	CDD:466817	128/282 (45%)
		PTZ00121	<278..446	CDD:173412	29/167 (17%)
		ASKHA_ATPase-like	<536..636	CDD:483947	38/103 (37%)
ACTR5	NP_079131.3	ASKHA_NBD_Arp5	32..568	CDD:466817	214/642 (33%)
		ASKHA_ATPase-like	<339..558	CDD:483947	72/308 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	584..607