DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Arp5 and Actr5

DIOPT Version :9

Sequence 1:	NP_001262697.1	Gene:	Arp5 / 42173	FlyBaseID:	FBgn0038576	Length:	648	Species:	Drosophila melanogaster
Sequence 2:	NP_001382533.1	Gene:	Actr5 / 362258	RGDID:	1307958	Length:	609	Species:	Rattus norvegicus

Alignment Length:	653	Identity:	224/653 - (34%)
Similarity:	347/653 - (53%)	Gaps:	114/653 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LVIDNGSYECRVGWS-----DSKEPDLRFRNVLTKPRKDRKKEAAASEGSASQTTVEQSAEIQVG 66
            ||:||||::.|.||:     ...||.|:||.|..:.|       ..:.|....         |||
  Rat    33 LVLDNGSFQARAGWACPGPDPGPEPRLQFRAVCARGR-------GGARGGLGP---------QVG 81

  Fly    67 NDITNIEAVRAHLKSPFERNVITNWNHQEQIFDYIFTKMGFDGQDKIDHPIILTEALANPNFCRQ 131
            |.:.::|.:|..|:|||:|||..|...||.:.||.|..:|...|..:||||:||||:.||.:.||
  Rat    82 NALGSLEPLRWMLRSPFDRNVPVNLELQELLLDYSFQHLGVSSQGCVDHPIVLTEAVCNPLYSRQ 146

  Fly   132 QMNELLFECYGIPSVSYGIDALYSWKHHQQKQKNISDALIISFGYSTTHVIPVLDGKLQLEHVRR 196
            .|:|||||||.||.|:||||:|:|:.|:..|.. :|..|:||.||..||::|||:|:|..::.:|
  Rat   147 MMSELLFECYRIPKVAYGIDSLFSFYHNMPKNA-LSSGLVISSGYQCTHILPVLEGRLDAKNCKR 210

  Fly   197 LNVGGYHIITYLFRLMQMKYPVHLNAITISRMEKLVHEHCHIAVDYKEELVQWAQMDYYDEHIMK 261
            :|:||.....||.||:|:|||.||.|||:||||:::.||.:||.||..||.:|...|||:.::.|
  Rat   211 INLGGSQAAGYLQRLLQLKYPGHLAAITLSRMEEILQEHSYIAEDYAAELQKWRCPDYYENNVHK 275

  Fly   262 IQLPYNAVTATNAMLTAEQKQEKRRELAHRLLDIKKNREQEKLREDEQQLFVYNKLRQLYEQKKL 326
            :|||::: ....:.||||:|||:|::...||.::...|.:|||:.|:::|.....:::|.|..::
  Rat   276 MQLPFSS-KLLGSTLTAEEKQERRQQQLRRLQELNARRREEKLQLDQERLERLLYVQELLEDGQM 339

  Fly   327 DKFERALQQQQIGTLEDLDSLIATINSRIKRAQERAQSGPRPSKQQERLNKMPKPPEGMSQADWL 391
            |:|.:||.:..:.:.|:|.|.|..:...:::|:::.... ..:.:.:.::..|:.|:       |
  Rat   340 DQFHKALIELNMDSPEELQSYIQKLTLAVEQAKQKILQA-EANLEVDVVDSKPETPD-------L 396

  Fly   392 AELQGKREKILGRKQARQQQRSEQAKRHTHAAQERMRIISSLAKNEKRRKANGEEEDDGFGMNDN 456
            ..|:...|.:                                                   .|.|
  Rat   397 EPLEPSLEDV---------------------------------------------------ENIN 410

  Fly   457 DWDVYKRINRYNDDSDSDADNEKLMQFDKILNHYDANTDGNSNVPPQ-SAAENYQLHFGVENIRV 520
            |::              ...:|:..:.:|        ....:.|.|. :.|..:||..|.|.||.
  Rat   411 DFE--------------PLFSEETPEVEK--------PQVTTTVQPVFNLAAYHQLFVGTERIRA 453

  Fly   521 PEVLFQPSMIGCSEAGLAELIAFVLKLFPAAEQQRLVEHVYLTGGCAQFKGLKERLIKELMEMRP 585
            ||::||||:||..:||:||.:.:||..:|.|.|..||::|:||||...:.|:|.|:.|||:||||
  Rat   454 PEIIFQPSLIGEEQAGIAETLHYVLDRYPKAVQDTLVQNVFLTGGNVMYPGMKARVEKELLEMRP 518

  Fly   586 FQSKFAIYESDEPTLSAWLG----ACVHAGEPTFGQTLTTRQDHQEHGREFFREHTASNIFYP-- 644
            |||.|.:..:..|.|.||.|    |..|..:   .....||:|::|.|.|:.:||.|||.:.|
  Rat   519 FQSSFQVQLASNPVLDAWYGARDWALDHLED---SGAWVTRKDYEEKGGEYLKEHCASNTYVPIR 580

  Fly   645 TPK 647
            .||
  Rat   581 LPK 583

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Arp5	NP_001262697.1	COG5277	1..637	CDD:227602	217/639 (34%)
Actr5	NP_001382533.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166338477
Domainoid	1	1.000	146	1.000	Domainoid score	I4440
eggNOG	1	0.900	-	-		E1_KOG0681
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6818
Inparanoid	1	1.050	311	1.000	Inparanoid score	I2519
OMA	1	1.010	-	-		QHG54909
OrthoDB	1	1.010	-	-		D178343at33208
OrthoFinder	1	1.000	-	-		FOG0005644
OrthoInspector	1	1.000	-	-		oto96872
orthoMCL	1	0.900	-	-		OOG6_104278
Panther	1	1.100	-	-	LDO	PTHR11937
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X4046
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.770