DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cdm and MTR10

DIOPT Version :9

Sequence 1:	NP_001262696.1	Gene:	cdm / 42171	FlyBaseID:	FBgn0261532	Length:	971	Species:	Drosophila melanogaster
Sequence 2:	NP_014803.1	Gene:	MTR10 / 854331	SGDID:	S000005686	Length:	972	Species:	Saccharomyces cerevisiae

Alignment Length:	959	Identity:	168/959 - (17%)
Similarity:	368/959 - (38%)	Gaps:	187/959 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MEPIDIARLEEAVVSFYRSNSQ---NQAITHEWLTDAEASPQAWQFSWQLMQLGKSQ------EV 56
            |:.:.::.:|.|:.....:.||   |:|:  ::|...:.|..||....::  |.|..      |:
Yeast     1 MDNLQVSDIETALQCISSTASQDDKNKAL--QFLEQFQRSTVAWSICNEI--LSKEDPTNALLEL 61

  Fly    57 QFFGAITLHSKLMKHWHEVPPENREELKQKILESIVRFAGGPKIVLNRLCISLGAYIVHMLGEWP 121
            ..|.|.||.:|:.....:: ..|..:.|..:|..::  :...|:::.:|.::|....:..| ||.
Yeast    62 NIFAAQTLRNKVTYDLSQL-ENNLPQFKDSLLTLLL--SHNQKLIITQLNVALARLAIQFL-EWQ 122

  Fly   122 GAIEEVINTFQNQRMPNVSADVQLWIMLEVLTAIPEEA-QVIHTSVKRVVLRAEIAKRVQLVIHT 185
            ..|.|:|:...:.  |:        |:|..|..:|||. .:..||:..|...:.|.:.:..:...
Yeast   123 NPIFEIISLLNSS--PS--------ILLNFLRILPEETLDIASTSLTEVEFNSRIHELIDPIAED 177

  Fly   186 VERYL----KLQMNRVWDAEAYSNMNRAVKCVGTWIKNIGYTIEGCVTITAVL---LEVVHKCYW 243
            |.::|    .|..|...::.:..::.:.::|:.:|  :..:.:|..:|:..::   .|.:.....
Yeast   178 VLKFLVSCIDLLQNTDGNSSSSISLEQILRCLNSW--SYEFPVEQLLTVQPLINLVFETISNGNE 240

  Fly   244 PCIHAGDG---CMTADENELAESCLKTMVNIIIQPDCHNYPKTAFVLIKMFLDSLSEITKTEWKR 305
            ..:.|.|.   |:.....|..::..:.:::.:            |..:.:..:.|.....|:...
Yeast   241 SDMEAFDSAIDCLCVILRESRDTTNEQLISAL------------FHQLMLLQEKLLPTLFTDHPL 293

  Fly   306 END-NEDIIVHIYMLFVSSVERHSTLLLSGITSADPELSILVHRIVQEILHCTDKPGIYPVEESC 369
            .:: ::|::..:..|||.:.|..|.::........|.:.:|:      :|.|.::      :...
Yeast   294 NDEYDDDLLEGMTRLFVEAGEAWSVVISKNPDFFKPMVLVLL------MLTCKNE------DLDV 346

  Fly   370 STMALAFWYMLQDEVFAMSNDEQKHKCWEYIKPLYAHLTRILVRKSEQPDEKSLAKWSSDDLECF 434
            .:....||:..:..: .:...::..|.:   ..::..|...::...:.|..:..:|...|.   |
Yeast   347 VSYTFPFWFNFKQSL-VLPRYQESRKAY---SDIFVKLINGIITHLQYPSGQFSSKEEEDK---F 404

  Fly   435 RCYRQDISDTFMYC------YDVLNDYILEILAAMLDEAIADLQRHPTHWTKLEACIYSFQSVAE 493
            :.:|..:.|....|      .:.|:..::.|.:|:         .:...|..:||.::|.:::|:
Yeast   405 KDFRYHMGDVLKDCTAVVGTSEALSQPLIRIKSAI---------ENNNSWQIMEAPLFSLRTMAK 460

  Fly   494 HFGGEEKRQIPRLMRVLAEIPYEKLNVKLLGTALETMGSYCNWLMENPAYIPPAINLLVRGL--- 555
            .....|...:|.:::::..:| |:..::...|.:  :|.|..|..::|..:...:..:..|.
Yeast   461 EISLTENTILPEIIKIICNLP-EQAKIRYASTLV--LGRYTEWTAKHPELLEVQLQYIFNGFQLH 522

  Fly   556 --NSSMSAQATL---GLKELCRDCQLQLKPYADPLLNACHASLNTGRMKNSDSVRLMFSIGKLMS 615
              :|.|.:..|.   .|...|.||...|..|.|.|:|   ..||   :::|..:...|.:.:.:|
Yeast   523 EGSSDMQSIITASSHALMFFCSDCSKLLVGYIDQLIN---FFLN---VQSSIDIESQFELCQGLS 581

  Fly   616 LL---RPE-EIPKYLDIIVSPCFEELQAICQADSKTPAARIRTIF-RLNMISTLFSSLNTDVDEQ 675
            .:   :|| ::......:|.....:::|:.......|......|. :::::..||..|     :.
Yeast   582 AVINNQPEAKVSVIFQKLVDDNLRQIEALIPQWKANPTLLAPQIADKIDLLYALFEEL-----KP 641

  Fly   676 ATDQPIVQPVLLVMQRTMPIFKRIAEMW------------VEEIDVLEAACSAMKHAITNLRSSF 728
            ..:.|        .|.:.|:..||..:|            :.:..::|.....::..........
Yeast   642 RYNYP--------QQGSEPLLPRIEFIWKALRTLLVDAGAMTDSIIVERVAKLLRRIFERFHVFC 698

  Fly   729 QPMLQDLCLFIVASFQTRCCAPTLEISKTAIVMFFKDEGCKPLMQQLLREFIQHSFKLFESTPEQ 793
            :|:|..:..|::..:.|......|..|.:.||:|..||                ||.:..|..:.
Yeast   699 EPILPSVAEFLIQGYLTTGFGSYLWCSGSLIVIFGDDE----------------SFPISPSLKDA 747

  Fly   794 NFSNISDTMETF------FGCLTQIIKKIPQVLEDKTLAYDRLVFYAQRGMTLPESGAIRNSIQF 852
            .:.......|||      |..| |:......:::..:|..|.::||         .||..||.:.
Yeast   748 VWKFALSQCETFILNFNKFDKL-QLNDYHEAIIDFFSLISDLIMFY---------PGAFLNSTEL 802

  Fly   853 LTHFVMQSRNHAHVTEVVL-ATGEQTLYTAMMCV----------GYLTP 890
            |          ..|..|.| ...:...|.|.:|:          |:.||
Yeast   803 L----------GPVLNVALECVNKLDNYDAYICILRCLDDIISWGFKTP 841

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cdm	NP_001262696.1	IBN_N	28..92	CDD:281761	15/69 (22%)
cdm	NP_001262696.1	Xpo1	98..>217	CDD:285575	25/123 (20%)
MTR10	NP_014803.1	IBN_N	28..97	CDD:197981	16/75 (21%)
MTR10	NP_014803.1	Xpo1	100..253	CDD:400614	31/165 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR12363
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3951
TreeFam	0	0.000	Not matched by this tool.
	3	3.010