Protein Alignment cdm and KAP122

DIOPT Version :10

• Sequence 1: NP_650682.1
• Gene: cdm / 42171
• FlyBaseID: FBgn0261532
• Length: 971
• Species: Drosophila melanogaster
• Sequence 2: NP_011499.1
• Gene: KAP122 / 852868
• SGDID: S000002984
• Length: 1081
• Species: Saccharomyces cerevisiae
• Alignment Length: 1107
• Identity: 207/1107 - (18%)
• Similarity: 394/1107 - (35%)
• Gaps: 267/1107 - (24%)

  Fly     5 DIARLEEAVVSFYRSNSQNQAITHEWLTDAEASPQAWQFSWQLMQLGK-SQEVQFFGAITLHSKL 68
            ::..|.|.:.|.:..:..||  ..:.|...:.|.|.:..:.:|:...| |..|::|||:||..:|
Yeast     6 EVVALIEELYSPHPKHDVNQ--IQQSLQSIQKSEQGFHLANELLSDDKYSANVKYFGALTLTVQL 68

  Fly    69 MKHWHEVPPENREELKQKILES----IVRFA----------GGPKIVLNRLCISLGAYIV----- 114
                 ....||..|....:..|    :.:|:          |...|::.:|..:|.....
Yeast    69 -----NTRGENDYETLWNVFRSNLLYLTKFSTLYVSNPNMYGQSLIIIKKLMSNLSLIFTKINDP 128

  Fly   115 --------HMLGEWPGAIEEVINTF------QNQRMPNVSADVQLWIMLEVLTAIPEEAQVIHTS 165
                    :|:.:|    ...||||      |||   |::||..|...:.......:.:|.:..|
Yeast   129 QLNNAGNENMIKQW----NNPINTFIQLMSVQNQ---NINADQLLLDSINCSLTYEQLSQFVSLS 186

  Fly   166 VKRVVLRAEIAKRV--QLVIHTVERYLKLQMNRVWDAEAY------SNMNRAVK---------CV 213
            .|...|.....:.:  .|.....:|:...|::.|.....|      .|:|...:         |:
Yeast   187 QKHNELALTFTEVIVEDLTKFQTKRHSMSQIHEVVHEHLYISTMALINLNLTAQAVFNPTVFDCI 251

  Fly   214 GTWIKNIGYT----IEGCVTITAVLLEVVHKCYWPCIHAGDGCMTADENELAESCLKTMVNI--- 271
            ..||..|..|    ..|.:.::.:...::...|    .:.:|   :|..|.||..|....|:
Yeast   252 TAWINYISLTRSVSSSGRMDLSEIFQNLIDLMY----QSTEG---SDGYENAEKILTIFGNVFAN 309

  Fly   272 ---IIQPDCHNYPKTAFVLIKMFLDSLSEIT-KTEWKRENDN----EDIIVHIYMLFVSSVE--R 326
               ::..|.....:..|:.:......:::|: |..|..:..|    .|....:..|.:..|:  :
Yeast   310 DPLLMSYDLRQQIECIFLGVVRPDSGITDISNKNSWMLQYMNYLVTNDFFSELKELAICIVDFLQ 374

  Fly   327 HSTL-----LLSGITSAD--PELSILVHRIVQEILHCTDKPGIYPVEESCSTMALAFWYMLQDEV 384
            .:||     |.:.|.:||  ......:...::.:|..|:.|....::|..|...:.||..|.|..
Yeast   375 INTLSVCNKLFTNIQAADNGQVQDEYIQEYIKVLLQMTNFPLTPVLQEFFSVRMVDFWLDLSDAY 439

  Fly   385 FAMSNDEQKHKCWEYIKPLYAHLTRILVRKSEQPDEKSL--AKWSSDDLECFRCYRQDISDTFMY 447
            ..::::..:....|....::..|..|.:.|.....::.:  .:..|..:..|..:|..:||....
Yeast   440 TNLASETLRPNSIELSTQIFQQLINIYLPKISLSVKQRIIEEEGESTSVNEFEDFRNAVSDLAQS 504

  Fly   448 CYDVL-ND-----------------------------YILEILAAMLDEAIADLQRHPTHWTK-- 480
            .:.:| ||                             :.:|.:..:|:..:.|:....:.|.|
Yeast   505 LWSILGNDNLTNVLIDGMGQMPAASDETLIIKDTDVLFRIETMCFVLNTILVDMTLSESPWIKNI 569

  Fly   481 LEACIYSFQSVAEHF-GGEEKRQIPRLMRVLAEIPYEKLNVKLLGTALETMGSYCNWLMENPAYI 544
            ::|..:..|:|...| .|.:.....::.::|      ||:.....|.|  :|:...:..:.|..:
Yeast   570 VDANKFFNQNVISVFQTGFQTSASTKVSQIL------KLDFVRTSTTL--IGTLAGYFKQEPFQL 626

  Fly   545 PPAINLLVRGL----------------NSSMSAQATLGLKELCRDCQLQLKPYADPLLNACHASL 593
            .|.:..|.:||                |..:.......:..||..|:.:|.||....:    :.|
Yeast   627 NPYVEALFQGLHTCTNFTSKNEQEKISNDKLEVMVIKTVSTLCETCREELTPYLMHFI----SFL 687

  Fly   594 NTGRMKNSD-----SVRLMFSIGKLMSLL---RPEEIPKY---LDIIVSPCFEELQAICQADSKT 647
            ||..|.:|:     ..:|:.|||.::...   .|||..||   |..::|...|.    |.|.|
Yeast   688 NTVIMPDSNVSHFTRTKLVRSIGYVVQCQVSNGPEEQAKYILQLTNLLSGSIEH----CLASS-- 746

  Fly   648 PAARIRTIFRLNMISTLFSSLNTDVDEQATDQPIVQPVLLVMQRTMPIFKRIAE---MWVEEIDV 709
                    .:|.......:.|...:.|.||.  ::||..::  ....:.:|::|   .|  ..|.
Yeast   747 --------VQLQEQQDYINCLLYCISELATS--LIQPTEII--ENDALLQRLSEFQSFW--SSDP 797

  Fly   710 LE----AACSAMKHAITNLRSSFQPMLQDLCLFI--------------------VASFQTRCCAP 750
            |:    ..|:..|....::.......::..||.:                    |.:|..| ..|
Yeast   798 LQIRSKIMCTIDKVLDNSIYCKNSAFVEIGCLIVGKGLNLPDGEPYFLKYNMSEVMNFVLR-HVP 861

  Fly   751 TLEISKTAIVMFFKDEGCKP----LMQQLLREFIQHSFKLFESTPEQNFSNISDTMETFFGCLTQ 811
            ..|::.           |.|    |:::|:.||.:      |.||::........:..::..
Yeast   862 NCELAT-----------CLPYFVYLLEKLISEFRK------ELTPQEFDFMFEKILLVYYDA--- 906

  Fly   812 IIKKIPQVLEDKTLAYDRLVFYAQRGMT----------LP---------ESGAIRNSIQFLTHFV 857
            .|...|.:|: .|:.:...|...:.|:.          ||         |...|....:|.|..:
Yeast   907 YIINDPDLLQ-MTIGFVNNVLDVKPGLAIGSKHWTSFILPQFLKLIPSREKFTIVAVAKFWTKLI 970

  Fly   858 MQSR-NHAHVTEV---VLATGEQTLYTAMMCVGYLTPRSQVDKFADILLAMNRKYAAEMAVWMKS 918
            ...: |...:|.|   |.:.|...:|..|..: :.|.||.::.:.|:|.|:..|:..|...|:.:
Yeast   971 NNKKYNQEELTTVRQQVSSIGGDLVYQIMYGL-FHTQRSDLNSYTDLLRALVAKFPIEAREWLVA 1034

  Fly   919 LM 920
            ::
Yeast  1035 VL 1036

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cdm	NP_650682.1	IBN_N	29..93	CDD:197981	17/68 (25%)
		Xpo1	98..>220	CDD:462459	30/157 (19%)
		Importin_rep	418..454	CDD:436727	6/38 (16%)
		Importin_rep_3	838..912	CDD:465873	20/96 (21%)
KAP122	NP_011499.1	None