Protein Alignment cdm and ipo13a

DIOPT Version :10

• Sequence 1: NP_650682.1
• Gene: cdm / 42171
• FlyBaseID: FBgn0261532
• Length: 971
• Species: Drosophila melanogaster
• Sequence 2: XP_694685.3
• Gene: ipo13a / 566321
• ZFINID: ZDB-GENE-130530-816
• Length: 945
• Species: Danio rerio
• Alignment Length: 993
• Identity: 274/993 - (27%)
• Similarity: 500/993 - (50%)
• Gaps: 88/993 - (8%)

  Fly     2 EPIDIARLEEAVVS-FYRSNSQNQAITHEWLTDAEASPQAWQFSWQLMQLGKSQEVQFFGAITLH 65
            |...:..:|.|:.. :|..:...:.:..:||::|:||||||||.|.|::..|..|:|||||.|||
Zfish     4 EEFTVEAVERALQQLYYDPDMGKKNVAQKWLSEAQASPQAWQFCWDLLRPEKVPEIQFFGASTLH 68

  Fly    66 SKLMKHWHEVPPENREELKQKILESIVRFAGGPKIVLNRLCISLGAYIVHMLGE-WPGAIEEVIN 129
            :|:.:||.|:|....:.|:.:::..:.:||.|||:||.|||::|.:.|:|:|.| ||.|:.:::.
Zfish    69 AKISRHWSELPAGQLDSLRSQLMAQVGQFAAGPKMVLTRLCVALASLILHILPETWPTAVPDILC 133

  Fly   130 TFQNQRMPNVSADVQLWIMLEVLTAIPEEAQV--IHTSVKRVVLRAEIAKRVQLVIHTVERYLKL 192
            .||.......|..:.|   ||:|..:|||.|.  |.|| :|..||:.:|.....|...:::.|:
Zfish   134 AFQTGEGDGPSRCLAL---LELLAVLPEELQSSRIVTS-RRSQLRSALAAHWSSVCRLLQQLLQ- 193

  Fly   193 QMNRVWDAEAYSNM-NRAVKCVGTWIKNIGYTIEGCVTITAVLLEVVHKCYWPCIHAGDGCMT-A 255
                  ..:|...: .|.::||.:||     |::.|:..:..:||              .|.| .
Zfish   194 ------QPDAPGRVRERVLRCVSSWI-----TLDVCLQDSEGILE--------------SCFTLL 233

  Fly   256 DENELAESCLKTMVNIIIQPDCHNYPKTAFVLIKMFLDSLSEITKTEWKRENDNEDIIVH-IYML 319
            .|:|:.::.::|:|.||.||||..:..:...::...| :|.|..|   |...|.:....| |..:
Zfish   234 KESEIFDAAVETIVCIISQPDCQRFVDSLLKVVPQVL-ALQEQLK---KAVQDGDMETSHGICRI 294

  Fly   320 FVSSVERHSTLLLSGITSADPELSILVH-----RIVQEILHCTDKPGIYPVEESCSTMALAFWYM 379
            .|:..|.|...||..:.          |     .:|..|:.||..||.|||:|:.|::.|.|||.
Zfish   295 AVALGETHCRTLLEQVD----------HWQGFQALVSMIMSCTATPGHYPVDETSSSLTLTFWYT 349

  Fly   380 LQDEVFAMSNDEQKHKCWEYIKPLYAHLTRILVRKSEQPDEKSLAKWSSDDLECFRCYRQDISDT 444
            |||::.::..:.|......| :|||..|..:|::|:..|.::....||:||.|.||.||.|||||
Zfish   350 LQDDITSLDAERQTLYLQIY-RPLYFQLVDVLLQKACFPRDEDFTAWSADDKEQFRTYRVDISDT 413

  Fly   445 FMYCYDVLNDYILEILAAMLDEAIADLQRHPTHWTKLEACIYSFQSVAEHFGGEEKRQIPRLMRV 509
            .||.|::|...:|..|...|...:.: ..||:.|..:|..::.|||:||.........||.|:.:
Zfish   414 LMYTYELLGPELLRNLYDKLGTLLTN-STHPSSWQDVETLLFGFQSIAETVDVSYSDVIPGLIGL 477

  Fly   510 LAEIPYEKLNVKLLGTALETMGSYCNWLMENPAYIPPAINLLVRGL-NSSMSAQATLGLKELCRD 573
            :..|...  |::|..|.:.|:||...||.::...:...:.::::|| |..:|......||.:||:
Zfish   478 IPLITAN--NIQLAETIMFTIGSLAEWLSDHSPMLANVLPVVLQGLSNPDLSVACVSALKRICRE 540

  Fly   574 CQLQLKPYADPLLNACHASLNTGRMKNSDSVRLMFSIGKLMSLLRPEEIPKYLDIIVSPCFEELQ 638
            |:..|..:|:.::....|.|.....|:...:.:|.::|.|:|.|..|||...|..:|:|..::|:
Zfish   541 CRHDLHLHANDIIVVSQAVLVKDIHKSPQCMWIMQALGFLLSALPREEILGKLLSLVTPHIQQLE 605

  Fly   639 AICQADSKTPAARIRTIFRLNMISTLFSSLNTDVDEQA---------TDQPI-VQPVLLVMQRTM 693
            .:. ::..:.|.::..:..|.::|.|||:.  |:::|:         ..||: ..||::|:|:..
Zfish   606 KLA-SEPPSSANKLLIVHILGLLSNLFSTF--DLNKQSERLEVMRHVQTQPLDNNPVVVVLQQAF 667

  Fly   694 PIFKRIAEMWVEEIDVLEAACSAMKHAITNLRSSFQPMLQDLCLFIVASFQTRCCAPTLEISKTA 758
            |:.:.:...|:.:.:|:||.|:..:.::..|...|.|::..||..|...|.....|..|::::..
Zfish   668 PLIQTVLNKWLSDPEVVEAVCAVFEKSLKTLIHDFAPLVTQLCELIGQMFSAYPQASALDLTRQL 732

  Fly   759 IVMFFKDEGCKPLMQQLLREFIQHSFKLFESTPEQNFSNISDTMETFFGCLTQIIKK-----IPQ 818
            :.:|..::.....:..||......:..:|:.....:    .|.:|:|....||::|:     :..
Zfish   733 VHIFACEKDLFSPITALLELITNITMSIFQLGSRDH----PDVVESFMQLHTQVLKRKADLYLSD 793

  Fly   819 VLEDKTLAYDRLVFYAQRGMTLPESGAIRNSIQFLTHFVMQSRNHAHVTEVVLATGEQTLYTAMM 883
            .|:.|.:.|..::.:     ..||:..::.:....|..:....:...|.:|:...|:..|.|.:.
Zfish   794 HLDIKAVFYCGILSF-----KFPETPTLKATCLLFTELISHYEDLPTVRDVLQEDGKLLLQTLLE 853

  Fly   884 CVGYLTPRSQVDKFADILLAMNRKYAAEMAVWMKSLMSTPNFPTQLITDADKTRYTALIIKEKVN 948
            .:|..:|||..:..|::|.:::|...:.:.:|::..:....||:..:|...|..:...|::|:|:
Zfish   854 AIGGQSPRSLAELLAEVLFSVSRNCPSLLTLWLRDALLPSGFPSSHLTAEHKEHFCQQILREQVS 918

  Fly   949 KRLLQQHLSEMAMKTRGL 966
            ||.::..:.|.|:.:|||
Zfish   919 KRQMKDIVKEFALLSRGL 936

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cdm	NP_650682.1	IBN_N	29..93	CDD:197981	29/63 (46%)
		Xpo1	98..>220	CDD:462459	41/125 (33%)
		Importin_rep	418..454	CDD:436727	19/35 (54%)
		Importin_rep_3	838..912	CDD:465873	15/73 (21%)
ipo13a	XP_694685.3	CRM1	5..>137	CDD:227432	51/131 (39%)
		IBN_N	30..91	CDD:197981	29/60 (48%)
		Xpo1	101..246	CDD:462459	49/174 (28%)
		Importin_rep	385..424	CDD:436727	19/38 (50%)
		HEAT repeat	433..458	CDD:293787	6/25 (24%)
		HEAT repeat	470..501	CDD:293787	10/32 (31%)
		HEAT repeat	512..540	CDD:293787	7/27 (26%)
		Importin_rep_2	567..610	CDD:408557	12/43 (28%)
		Importin_rep_3	809..882	CDD:465873	15/72 (21%)