Protein Alignment cdm and Ipo13

DIOPT Version :10

• Sequence 1: NP_650682.1
• Gene: cdm / 42171
• FlyBaseID: FBgn0261532
• Length: 971
• Species: Drosophila melanogaster
• Sequence 2: NP_666264.1
• Gene: Ipo13 / 230673
• MGIID: 2385205
• Length: 963
• Species: Mus musculus
• Alignment Length: 987
• Identity: 278/987 - (28%)
• Similarity: 492/987 - (49%)
• Gaps: 81/987 - (8%)

  Fly     6 IARLEEAVVS-FYRSNSQNQAITHEWLTDAEASPQAWQFSWQLMQLGKSQEVQFFGAITLHSKLM 69
            :..:|:|:.. :|..|..|:.:..:||..|:.|||||.|||||:|..|..|:|:|||..||.|:.
Mouse    23 VENVEKALHQLYYDPNIDNKNLAQKWLMQAQVSPQAWHFSWQLLQPDKVPEIQYFGASALHIKIS 87

  Fly    70 KHWHEVPPENREELKQKILESIVRFAGGPKIVLNRLCISLGAYIVHMLGE-WPGAIEEVINTFQN 133
            ::|.::|.:..|.||.::...|.|||.|.||||.|||::|.:..:.|:.: ||.|:.:::..||.
Mouse    88 RYWSDIPTDQYESLKAQLFTQITRFASGSKIVLTRLCVALASLALSMMPDAWPCAVADMVRLFQA 152

  Fly   134 QRMPNVSADVQLWIMLEVLTAIPEEAQVIH-TSVKRVVLRAEIAKRVQLVIHTVERYLKLQMNRV 197
            :..| |.:..:...:||:||.:|||.|... ...::.::|..:|.....|...:|:.|:
Mouse   153 EDSP-VDSQGRCLALLELLTVLPEEFQTSRLPQYRKGLVRTSLAVECGTVFPLLEQLLQ------ 210

  Fly   198 WDAEAYSNMNRAVKCVGTWIKNIGYTIEGCVTITAVLLEVVHKCYWPCIHAGDGCMTADENELAE 262
            ..:.......:.:||..:|:: :...::.|..:               |.|....:  .::||.:
Mouse   211 QPSSPSCVRQKVLKCFSSWVQ-LEVPLQDCEAL---------------IQAAFAAL--QDSELFD 257

  Fly   263 SCLKTMVNIIIQPDCHNYPKTAFVLIKMFLDSLSEITKTEWKRENDNEDIIVHIYMLFVSSVERH 327
            |.::.:||.|.|||...|..|...||.:.|....::.:..   :|.:.:....|..:.|:..|.|
Mouse   258 SSVEAIVNAISQPDAQRYVNTLLKLIPLVLGLQEQLRQAV---QNGDMETSHGICRIAVALGENH 319

  Fly   328 STLLLSGITSADPELSILVHRIVQEILHCTDKPGIYPVEESCSTMALAFWYMLQDEVFAMSNDEQ 392
            |..||..:......|:     :|..|:.||..||.|||.|:.|::.|.|||.|||::  :|.:.:
Mouse   320 SRALLDQVEHWQSFLA-----LVNMIMFCTGIPGHYPVNETTSSLTLTFWYTLQDDI--LSFEAE 377

  Fly   393 KHKCWEYI-KPLYAHLTRILVRKSEQPDEKSLAKWSSDDLECFRCYRQDISDTFMYCYDVLNDYI 456
            |...::.: :|:|..|..:|:.|::.|.::....||||:.|.||.||.|||||.||.|::|.
Mouse   378 KQAVYQQVYRPVYFQLVDVLLHKAQFPSDEEYGFWSSDEKEQFRIYRVDISDTLMYVYEMLG--- 439

  Fly   457 LEILAAMLDE--AIADLQRHPTHWTKLEACIYSFQSVAEHFGGEEKRQIPRLMRVLAEIPYEKLN 519
            .|:|:.:.|:  .:......|..|...||.:|.|||:||.........:|.|:.::..|...  |
Mouse   440 AELLSNLYDKLGRLLTSSEEPYSWQHTEALLYGFQSIAETIDVNYSDVVPGLIGLIPRISIS--N 502

  Fly   520 VKLLGTALETMGSYCNWLMENPAYIPPAINLLVRGL-NSSMSAQATLGLKELCRDCQLQLKPYA- 582
            |:|..|.:.|:|:...||.::|..|...:.|::..| |..:|..:...||::||:|:..|.|||
Mouse   503 VQLADTVMFTIGALSEWLADHPVMINSVLPLVLHALGNPELSVSSVSTLKKICRECKYDLPPYAA 567

  Fly   583 -------DPLLNACHASLNTGRMKNSDSVRLMFSIGKLMSLLRPEEIPKYLDIIVSPCFEELQAI 640
                   |.|:...|        |.|..:.||.::|.|:|.|:.|||.|.|..::||..::|:.:
Mouse   568 NIVAVSQDVLMKQIH--------KTSQCMWLMQALGFLLSALQVEEILKNLHSLISPYIQQLEKL 624

  Fly   641 CQADSKTPAARIRTIFRLNMISTLFSSLNTDVDEQATDQ--------PIVQ---PVLLVMQRTMP 694
            .: :...|:.::..:..|.::|.||::|  ||.....|.        |:.|   ||::|:|:...
Mouse   625 AE-EIPNPSNKLAIVHILGLLSNLFTTL--DVSHHEDDHEGPELRKLPVPQGPNPVVVVLQQVFQ 686

  Fly   695 IFKRIAEMWVEEIDVLEAACSAMKHAITNLRSSFQPMLQDLCLFIVASFQTRCCAPTLEISKTAI 759
            :.:::...|:.:..|:||.|:..:.::..|...|.||:..||..:...:.|...|..|::::..:
Mouse   687 LIQKVLSKWLNDAQVVEAVCAIFEKSVKTLLDDFAPMVPQLCEMLGRMYSTVPQASALDLTRQLV 751

  Fly   760 VMFFKDEGCKPLMQQLLREFIQHSFKLFESTPEQNFSNISDTMETFFGCLTQIIKKIPQVLEDKT 824
            .:|..:....|.::.|.......:..||:..|..:    .|.:::|...|.|.:|:.|.:...:.
Mouse   752 HIFAHEPAHFPPIEALFLLVTSVTLSLFQQGPRDH----PDIVDSFMQLLAQALKRKPDLFLCER 812

  Fly   825 LAYDRLVFYAQRGMTLPESGAIRNSIQFLTHFVMQSRNHAHVTEVVLATGEQTLYTAMMCVGYLT 889
            |....:...|...:..||:..::.|..|.|..:.:......|.:||...|...|...:..:|...
Mouse   813 LDVKAVFQCAVLALKFPEAPTVKASCGFFTELLPRCGEIESVGKVVQEDGRMLLIAVLEAIGGQA 877

  Fly   890 PRSQVDKFADILLAMNRKYAAEMAVWMKSLMSTPNFPTQLITDADKTRYTALIIKEKVNKRLLQQ 954
            .||.:|.|||||.|:|:...:.:::|:|..:..|.||:..::...|..::..|::|:||||.:::
Mouse   878 SRSLMDCFADILFALNKHCFSLLSMWIKEALQPPGFPSARLSPEQKDTFSQQILRERVNKRRVKE 942

  Fly   955 HLSEMAMKTRGL 966
            .:.|..:..|||
Mouse   943 MVKEFTLLCRGL 954

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cdm	NP_650682.1	IBN_N	29..93	CDD:197981	29/63 (46%)
		Xpo1	98..>220	CDD:462459	32/123 (26%)
		Importin_rep	418..454	CDD:436727	19/35 (54%)
		Importin_rep_3	838..912	CDD:465873	21/73 (29%)
Ipo13	NP_666264.1	HEAT 1	24..54		8/29 (28%)
		IBN_N	45..109	CDD:197981	28/63 (44%)
		HEAT 2	56..88		19/31 (61%)
		HEAT 3	95..135		16/39 (41%)
		Xpo1	116..263	CDD:462459	38/171 (22%)
		HEAT 4	142..179		12/37 (32%)
		HEAT 5	194..231		7/42 (17%)
		HEAT 6	236..268		8/48 (17%)
		HEAT 7	276..325		11/51 (22%)
		HEAT 8	330..372		19/48 (40%)
		HEAT 9	375..438		24/62 (39%)
		Importin_rep	402..441	CDD:436727	19/41 (46%)
		HEAT 10	440..476		10/35 (29%)
		HEAT 11	487..522		11/36 (31%)
		HEAT 12	524..558		10/33 (30%)
		HEAT 13	562..600		13/45 (29%)
		Importin_rep_2	584..627	CDD:408557	15/43 (35%)
		HEAT 14	603..648		11/45 (24%)
		Importin_rep_2	631..669	CDD:408557	9/39 (23%)
		HEAT 15	676..716		9/39 (23%)
		HEAT 16	720..754		8/33 (24%)
		HEAT 17	761..803		9/45 (20%)
		HEAT 18	815..845		6/29 (21%)
		Importin_rep_3	826..900	CDD:465873	21/73 (29%)
		HEAT 19	860..893		12/32 (38%)
		HEAT 20	897..931		6/33 (18%)