DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment cdm and cdm

DIOPT Version :10

Sequence 1:NP_650682.1 Gene:cdm / 42171 FlyBaseID:FBgn0261532 Length:971 Species:Drosophila melanogaster
Sequence 2:XP_061516092.1 Gene:cdm / 1278932 VectorBaseID:AGAMI1_004099 Length:1003 Species:Anopheles gambiae


Alignment Length:1006 Identity:440/1006 - (43%)
Similarity:629/1006 - (62%) Gaps:51/1006 - (5%)


- Green bases have known domain annotations that are detailed below.


  Fly     5 DIARLEEAVVSFYRSNSQNQAITHEWLTDAEASPQAWQFSWQLMQLGKSQEVQFFGAITLHSKLM 69
            ::..:|.||:||||..|:.|..||:||...:.|||||.|.|:||||.||.|:||||||||:|||.
Mosquito     3 EVQTIEAAVLSFYRGGSEQQKETHKWLQQVQNSPQAWSFCWELMQLNKSSEIQFFGAITLNSKLR 67

  Fly    70 KHWHEVPPENREELKQKILESIVRFAGGPKIVLNRLCISLGAYIVHMLGEWPGAIEEVINTFQNQ 134
            ..|.|||.|...|||||:||:||.|..||||||||||||||.:||||| ..|..||||.|.|.::
Mosquito    68 SDWAEVPKEAHHELKQKLLETIVLFGNGPKIVLNRLCISLGLFIVHML-RHPTVIEEVTNMFLHE 131

  Fly   135 RMPNVSADVQLWIMLEVLTAIPEEAQVIHTSVKRVVLRAEIAKRVQLVIHTVERYLKLQMNRVWD 199
            ::.|:|...|:.|::.||..||||.:.|.|.:.|.|:..|:.:..:.|:.||..||..:::|  .
Mosquito   132 QLGNLSKVTQIEILMAVLEGIPEEVKNIRTQIPRTVVCEELNRNAEFVMQTVVTYLNEKLSR--S 194

  Fly   200 AEAYSNMN---RAVKCVGTWIKNIGYTIEGCVTITAVLLEVVHKCYW--PCIHAGDGCMTADENE 259
            |....:||   .|.||.|||:.:....:.....:...||:.:|.|||  |   ..|||:..:|||
Mosquito   195 AVEPHDMNGLINAAKCTGTWVAHGNVHLNDREGMIQTLLKAIHYCYWKEP---KDDGCLMPEENE 256

  Fly   260 LAESCLKTMVNIIIQPDCHN--YPKTAFVLIKMFLDSLSEITKTEWKRENDNEDIIVHIYMLFVS 322
            |||:.||::.|||......|  |..|....:|:|||.|..|...|:|..||||::.:.||.||:|
Mosquito   257 LAETALKSLANIISSYATQNAKYSFTVINYMKLFLDVLVPILDAEYKENNDNENLALMIYALFIS 321

  Fly   323 SVERHSTLLLSGITSADPELSILVHRIVQEILHCTDKPGIYPVEESCSTMALAFWYMLQDEVFAM 387
            ::|..|:.:.:||.:...|:|.:..|.|..::.||||||.|||:|||||.|:.||||||:||.:|
Mosquito   322 TLECFSSAIFAGIVTDSEEVSKVYTRTVDMLIKCTDKPGTYPVDESCSTYAMEFWYMLQEEVLSM 386

  Fly   388 SNDEQKHKCWEYIKPLYAHLTRILVRKSEQPDEKSLAKWSSDDLECFRCYRQDISDTFMYCYDVL 452
            .:.|.|.:|.|.|||:|||:.::|||||:.|.|.||.||:.||||.||||||||.||.:.|:|||
Mosquito   387 DSGEHKKRCLEAIKPVYAHVVKVLVRKSQLPTESSLHKWNDDDLEAFRCYRQDIGDTLLSCHDVL 451

  Fly   453 NDYILEILAAMLDEAIADLQRHP---THWTKLEACIYSFQSVAEHFGGEEKRQIPRLMRVLAEIP 514
            ||.:|::|:..|:|:|..|...|   ..||.|||.|::|.|:|:.....|.:||.:|::||.|||
Mosquito   452 NDLMLDVLSEALEESIMYLSYDPQSTESWTLLEATIHAFCSIAQKIEYTEHQQIVKLLKVLNEIP 516

  Fly   515 YEKLNVKLLGTALETMGSYCNWLMENPAYIPPAINLLVRGLNSSMSAQATLGLKELCRDCQLQLK 579
            |||.:.||.|.||||:|:|..|:.:||.|:|.||.|||:||||:.::|||||||:|..:||.::.
Mosquito   517 YEKYSDKLFGMALETVGAYSEWIGDNPKYLPSAITLLVKGLNSTKASQATLGLKDLTSECQKEVI 581

  Fly   580 PYADPLLNACHASLNTGRMKNSDSVRLMFSIGKLMSLLRPEEIPKYLDIIVSPCFEELQAICQAD 644
            |||.|||:||..:|..|.:||::.:|||:::|.::|::..|.|..|||.:|||||||||...|.:
Mosquito   582 PYALPLLDACRTALQEGHLKNAEMIRLMYTVGNILSVISYENIILYLDAMVSPCFEELQVHVQNN 646

  Fly   645 SKTPAARIRTIFRLNMISTLFSSLNT------DVDE------------------QATDQPIVQPV 685
            .:|...:.|.:.||.|||.||||||.      |:|:                  .|...| |||:
Mosquito   647 DRTEPTKARVVLRLEMISKLFSSLNIRKPTEGDMDKGLVVGVGPHKLPFPAGGTPAPGAP-VQPI 710

  Fly   686 LLVMQRTMPIFKRIAEMWVEEIDVLEAACSAMKHAITNLRSSFQPMLQDLCLFIVASFQTRCCAP 750
            ||::::||.:.|.:..:|:.:..|::..|.|::.|:|||....:|:|.::|..:::...|.|...
Mosquito   711 LLILEKTMGLLKSLCTLWIHDETVIDTLCKALQQALTNLMDDIKPLLTEMCCLVLSILNTNCVVS 775

  Fly   751 TLEISKTAIVMFFKDEGCKPLMQQLLREFIQHSFKLFESTPEQNFSNISDTMETFFGCLTQIIKK 815
            ..:|:...|:||:||:.|:.||.||....:.::|...|....: .|.|:|.:|||:...|:|.||
Mosquito   776 AADIAGNFILMFYKDQDCRQLMVQLFTAIMDYNFNQMERNVGK-LSRIADLIETFYAFNTRISKK 839

  Fly   816 IPQVLEDKTLAYDRLVFYAQRGMTLPESGAIRNSIQFLTHFVMQSRNHAHVTEVVLATGEQTLYT 880
            ||....:..:...:||.||.:.|.|||:|.::.|:.|:|.||.:|.||..:..|:||.||..:.:
Mosquito   840 IPICYSEVQIDCMKLVDYATKCMMLPETGPMKKSVAFITMFVKESTNHPVMMNVILAQGENIVRS 904

  Fly   881 AMMCVGYLTPRSQVDKFADILLAMNRKYAAEMAVWMKSLMSTPNFPTQLITDADKTRYTALII-- 943
            ..:|:|....|:||:.||||.||:|.:|.||...||| |:..|||||..::..||.::...||  
Mosquito   905 TFLCIGGTALRTQVEIFADIFLALNFRYPAEFIQWMK-LLEVPNFPTAYVSATDKEQFMRKIINE 968

  Fly   944 ------KEKVNKRLLQQHLSEMAMKTRGLTE 968
                  :|:|||||:|.|:.:.|...|.:.|
Mosquito   969 MNTLFSRERVNKRLVQDHVRKFAALCRNIVE 999

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
cdmNP_650682.1 IBN_N 29..93 CDD:197981 40/63 (63%)
Xpo1 98..>220 CDD:462459 55/124 (44%)
Importin_rep 418..454 CDD:436727 24/35 (69%)
Importin_rep_3 838..912 CDD:465873 32/73 (44%)
cdmXP_061516092.1 None

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