DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cdm and Ipo13

DIOPT Version :9

Sequence 1:	NP_001262696.1	Gene:	cdm / 42171	FlyBaseID:	FBgn0261532	Length:	971	Species:	Drosophila melanogaster
Sequence 2:	NP_446230.2	Gene:	Ipo13 / 116458	RGDID:	620071	Length:	963	Species:	Rattus norvegicus

Alignment Length:	987	Identity:	279/987 - (28%)
Similarity:	495/987 - (50%)	Gaps:	81/987 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 IARLEEAVVS-FYRSNSQNQAITHEWLTDAEASPQAWQFSWQLMQLGKSQEVQFFGAITLHSKLM 69
            :..:|:|:.. :|..|.:|:.:..:||..|:.|||||.|||||:|..|..|:|:|||..||.|:.
  Rat    23 VENVEKALHQLYYDPNIENKNLAQKWLMQAQVSPQAWHFSWQLLQPDKVPEIQYFGASALHIKIS 87

  Fly    70 KHWHEVPPENREELKQKILESIVRFAGGPKIVLNRLCISLGAYIVHMLGE-WPGAIEEVINTFQN 133
            ::|.::|.:..|.||.::...|.|||.|.||||.|||::|.:..:.|:.: ||.|:.:::..||.
  Rat    88 RYWSDIPTDQYESLKAQLFTQITRFASGSKIVLTRLCVALASLALSMMPDAWPCAVADMVRLFQA 152

  Fly   134 QRMPNVSADVQLWIMLEVLTAIPEEAQVIH-TSVKRVVLRAEIAKRVQLVIHTVERYLKLQMNRV 197
            :..| |.:..:...:||:||.:|||.|... ...::.::||.:|.....|...:|:.|:
  Rat   153 EDSP-VDSQGRCLALLELLTVLPEEFQTSRLPQYRKGLVRASLAVECGAVFPLLEQLLQ------ 210

  Fly   198 WDAEAYSNMNRAVKCVGTWIKNIGYTIEGCVTITAVLLEVVHKCYWPCIHAGDGCMTADENELAE 262
            ..:.......:.:||..:|:: :...::.|..:               |.|....:  .::||.:
  Rat   211 QPSSPSCVRQKVLKCFSSWVQ-LEVPLQDCEAL---------------IQAAFAAL--QDSELFD 257

  Fly   263 SCLKTMVNIIIQPDCHNYPKTAFVLIKMFLDSLSEITKTEWKRENDNEDIIVHIYMLFVSSVERH 327
            |.::.:||.|.|||...|..|...||.:.|....::.:..   :|.:.:....|..:.|:..|.|
  Rat   258 SSVEAIVNAISQPDAQRYVNTLLKLIPLVLGLQEQLRQAV---QNGDMETSHGICRIAVALGENH 319

  Fly   328 STLLLSGITSADPELSILVHRIVQEILHCTDKPGIYPVEESCSTMALAFWYMLQDEVFAMSNDEQ 392
            |..||..:......|:     :|..|:.||..||.|||.|:.|::.|.|||.|||::  :|.:.:
  Rat   320 SRALLDQVEHWQSFLA-----LVNMIMFCTGIPGHYPVNETTSSLTLTFWYTLQDDI--LSFEAE 377

  Fly   393 KHKCWEYI-KPLYAHLTRILVRKSEQPDEKSLAKWSSDDLECFRCYRQDISDTFMYCYDVLNDYI 456
            |...::.: :|:|..|..:|:.|::.|.::....||||:.|.||.||.|||||.||.|::|.
  Rat   378 KQAVYQQVYRPVYFQLVDVLLHKAQFPSDEEYGFWSSDEKEQFRIYRVDISDTLMYVYEMLG--- 439

  Fly   457 LEILAAMLDE--AIADLQRHPTHWTKLEACIYSFQSVAEHFGGEEKRQIPRLMRVLAEIPYEKLN 519
            .|:|:.:.|:  .:......|..|...||.:|.|||:||.........:|.|:.::..|...  |
  Rat   440 AELLSNLYDKLGRLLTSSEEPYSWQHTEALLYGFQSIAETIDVNYSDVVPGLIGLIPRISIS--N 502

  Fly   520 VKLLGTALETMGSYCNWLMENPAYIPPAINLLVRGL-NSSMSAQATLGLKELCRDCQLQLKPYA- 582
            |:|..|.:.|:|:...||.::|..|...:.|::..| |..:|..:...||::||:|:..|.|||
  Rat   503 VQLADTVMFTIGALSEWLADHPVMINSVLPLVLHALGNPELSVSSVSTLKKICRECKYDLPPYAA 567

  Fly   583 -------DPLLNACHASLNTGRMKNSDSVRLMFSIGKLMSLLRPEEIPKYLDIIVSPCFEELQAI 640
                   |.|:...|        |.|..:.||.::|.|:|.|:.|||.|.|..::||..::|:.:
  Rat   568 NIVAVSQDVLMKQIH--------KTSQCMWLMQALGFLLSALQVEEILKNLHSLISPYIQQLEKL 624

  Fly   641 CQADSKTPAARIRTIFRLNMISTLFSSLNTDVDEQATDQ--------PIVQ---PVLLVMQRTMP 694
            .: :...|:.::..:..|.::|.||::|  ||.....|.        |:.|   ||::|:|:...
  Rat   625 AE-EIPNPSNKLAIVHILGLLSNLFTTL--DVSHHEDDHEGPELRKLPVPQGPNPVVVVLQQVFQ 686

  Fly   695 IFKRIAEMWVEEIDVLEAACSAMKHAITNLRSSFQPMLQDLCLFIVASFQTRCCAPTLEISKTAI 759
            :.:::...|:.:..|:||.|:..:.::..|...|.||:..||..:...:.|...|..|::::..:
  Rat   687 LIQKVLSKWLSDAQVVEAVCAIFEKSVKTLLDDFAPMVPQLCEMLGRMYSTVPQASALDLTRQLV 751

  Fly   760 VMFFKDEGCKPLMQQLLREFIQHSFKLFESTPEQNFSNISDTMETFFGCLTQIIKKIPQVLEDKT 824
            .:|..:....|.::.|.......:..||:..|..:    .|.:::|...|.|.:|:.|.:.:.:.
  Rat   752 HIFAHEPAHFPPIEALFLLVTSVTLSLFQQGPRDH----PDIVDSFMQLLAQALKRKPDLFQCER 812

  Fly   825 LAYDRLVFYAQRGMTLPESGAIRNSIQFLTHFVMQSRNHAHVTEVVLATGEQTLYTAMMCVGYLT 889
            |....:...|...:..||:..::.|..|.|..:.:......|.:||...|...|...:..:|...
  Rat   813 LDVKAVFQCAVLALKFPEAPTVKASCGFFTELLPRCGEIESVGKVVQEDGRMLLIAVLEAIGGQA 877

  Fly   890 PRSQVDKFADILLAMNRKYAAEMAVWMKSLMSTPNFPTQLITDADKTRYTALIIKEKVNKRLLQQ 954
            .||.:|.|||||.|:|:...:.:::|:|..:..|.||:..::...|..::..|::|:||||.:::
  Rat   878 SRSLMDCFADILFALNKHCFSLLSMWIKEALQPPGFPSARLSPEQKDTFSQQILRERVNKRRVKE 942

  Fly   955 HLSEMAMKTRGL 966
            .:.|..:..|||
  Rat   943 MVKEFTLLCRGL 954

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cdm	NP_001262696.1	IBN_N	28..92	CDD:281761	28/63 (44%)
cdm	NP_001262696.1	Xpo1	98..>217	CDD:285575	32/120 (27%)
Ipo13	NP_446230.2	HEAT 1	24..54		8/29 (28%)
		IBN_N	45..109	CDD:197981	28/63 (44%)
		HEAT 2	56..88		19/31 (61%)
		HEAT 3	95..135		16/39 (41%)
		Xpo1	117..263	CDD:400614	39/170 (23%)
		HEAT 4	142..179		12/37 (32%)
		HEAT 5	194..231		7/42 (17%)
		HEAT 6	236..268		8/48 (17%)
		HEAT 7	276..325		11/51 (22%)
		HEAT 8	330..372		19/48 (40%)
		HEAT 9	375..438		24/62 (39%)
		Importin_rep	402..441	CDD:408544	19/41 (46%)
		HEAT 10	440..476		10/35 (29%)
		HEAT 11	487..522		11/36 (31%)
		HEAT 12	524..558		10/33 (30%)
		HEAT 13	562..600		13/45 (29%)
		Importin_rep_2	584..627	CDD:408557	15/43 (35%)
		HEAT 14	603..648		11/45 (24%)
		Importin_rep_2	631..669	CDD:408557	9/39 (23%)
		HEAT 15	676..716		9/39 (23%)
		HEAT 16	720..754		8/33 (24%)
		HEAT 17	761..803		9/45 (20%)
		HEAT 18	815..845		6/29 (21%)
		Importin_rep_3	826..900	CDD:408577	21/73 (29%)
		HEAT 19	860..893		12/32 (38%)
		HEAT 20	897..931		6/33 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166336646
Domainoid	1	1.000	71	1.000	Domainoid score	I9268
eggNOG	1	0.900	-	-		E1_KOG2022
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H40968
Inparanoid	1	1.050	428	1.000	Inparanoid score	I1680
OMA	1	1.010	-	-		QHG55969
OrthoDB	1	1.010	-	-		D1032285at2759
OrthoFinder	1	1.000	-	-		FOG0004114
OrthoInspector	1	1.000	-	-		oto98360
orthoMCL	1	0.900	-	-		OOG6_104367
Panther	1	1.100	-	-	LDO	PTHR12363
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3951
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.770