DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cdm and ipo13

DIOPT Version :9

Sequence 1:	NP_001262696.1	Gene:	cdm / 42171	FlyBaseID:	FBgn0261532	Length:	971	Species:	Drosophila melanogaster
Sequence 2:	XP_002931629.1	Gene:	ipo13 / 100493086	XenbaseID:	XB-GENE-491680	Length:	954	Species:	Xenopus tropicalis

Alignment Length:	974	Identity:	279/974 - (28%)
Similarity:	488/974 - (50%)	Gaps:	76/974 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 FYRSNSQNQAITHEWLTDAEASPQAWQFSWQLMQLGKSQEVQFFGAITLHSKLMKHWHEVPPENR 80
            :|..|.:|:.:..:||..|:.|||||||||||:..||..|:|:|||..||.|:.::|.::|.|..
Frog    25 YYDPNIENKNMAQKWLMQAQISPQAWQFSWQLLNGGKVPEIQYFGASALHIKISRYWGDIPAEQY 89

  Fly    81 EELKQKILESIVRFAGGPKIVLNRLCISLGAYIVHMLGE-WPGAIEEVINTFQNQRMPNVSADVQ 144
            |.||.::...|..||.|.||||.|||::|.:..::|:.: ||.|:.:::..||.:. .......:
Frog    90 ESLKSQLFAQISVFASGSKIVLTRLCVALASLALNMMPDTWPHAVSDMVRVFQKED-GQTDGGSR 153

  Fly   145 LWIMLEVLTAIPEEAQVIHTS----VKRVVLRAEIAKRVQLVIHTVERYLKLQMNRVWDAEAYSN 205
            ...:||:||.:|||.|   ||    .::.::|:.:|:....|...:.:.|:..     |...:..
Frog   154 CLALLELLTVLPEEFQ---TSRLPPYRKGIVRSSLAQECTCVFPLLRQLLEQS-----DTPGFVK 210

  Fly   206 MNRAVKCVGTWIKNIGYTIEGCVTITAVLLEVVHKCYWPCIHAGDGCMTADENELAESCLKTMVN 270
             .:.:||..:|.: :...:..|..:|......:.                 :.||.:|.::.:||
Frog   211 -QKVLKCFSSWAQ-LEIPLTECEELTLAAFSALR-----------------DPELFDSAVEALVN 256

  Fly   271 IIIQPDCHNYPKTAFVLIKMFLDSLSEITKTEWKRENDNEDIIVHIYMLFVSSVERHSTLLLSGI 335
            .|.|||...|..|   |:|:...:||...:.....:|.:.:....|..:.|:..|.||...|..:
Frog   257 TISQPDAQRYVNT---LLKLIPQALSLQDQLHQAVQNGDLETSHGICRIVVALGENHSRAFLDQV 318

  Fly   336 TSADPELSILVHRIVQEILHCTDKPGIYPVEESCSTMALAFWYMLQDEVFAMSNDEQKHKCWEYI 400
               |...|.|.  :|..|:.||..||.|||.|:.|::.|.|||.|||::|:...::|......|
Frog   319 ---DHWQSFLA--LVNMIMFCTGIPGHYPVNETTSSLTLTFWYSLQDDIFSFEAEKQAVYLQVY- 377

  Fly   401 KPLYAHLTRILVRKSEQPDEKSLAKWSSDDLECFRCYRQDISDTFMYCYDVLNDYILEILAAMLD 465
            :|:|..|..:|::|::.|.::..|.||||:.|.||.||.|||||.||.|::|...:|..|...|.
Frog   378 RPVYFQLVDVLLQKAQFPADEEYASWSSDEKEQFRIYRVDISDTLMYVYEMLGAELLSNLYDKLG 442

  Fly   466 EAIADLQRHPTHWTKLEACIYSFQSVAEHFGGEEKRQIPRLMRVLAEIPYEKLNVKLLGTALETM 530
            ..:....: .|.|...||.:|.|||:||.........:|.|:.::..|...  ||:|..|.:.|:
Frog   443 RLLTSSDQ-STSWQHTEALLYGFQSIAETIDVNYSDVVPGLIGLIPRININ--NVQLADTVMFTI 504

  Fly   531 GSYCNWLMENPAYIPPAINLLVRGL-NSSMSAQATLGLKELCRDCQLQLKPYA--------DPLL 586
            |:...||.::|..|...:.|::..| |..:|..:...||::||:|:..|.|||        :.||
Frog   505 GALAEWLADHPVMISKVLPLVLHALGNPELSVSSVSTLKKICRECKYDLPPYAANIVAVSQEVLL 569

  Fly   587 NACHASLNTGRMKNSDSVRLMFSIGKLMSLLRPEEIPKYLDIIVSPCFEELQAICQADSKTPAAR 651
            ...|        |.|..:.||.::|.|:|:|:.|||...|..:::|..::|:.:.. ::..|:.:
Frog   570 KQIH--------KTSQCMWLMQALGFLLSVLQVEEILSNLHSLITPYIQQLEKLAD-ETPNPSNK 625

  Fly   652 IRTIFRLNMISTLFSSLNT---DVDEQATD---QPIVQ---PVLLVMQRTMPIFKRIAEMWVEEI 707
            :..|..|.::|.||::|:.   |.|.::.:   .|:||   ||:||:|:...:.|::...|:.:.
Frog   626 VAIIHILGLLSNLFTTLDISHHDDDHESGEVKKLPVVQGPNPVVLVLQQVFQLIKKVLSTWLNDA 690

  Fly   708 DVLEAACSAMKHAITNLRSSFQPMLQDLCLFIVASFQTRCCAPTLEISKTAIVMFFKDEGCKPLM 772
            .|:||.|:..:.::..|...|.||:..||..:...:.|...|..:::::..:.:|..:....|.:
Frog   691 QVVEAVCAIFEKSVKTLLDDFAPMVPQLCDMLGQMYSTIPQASAIDLTRQLVHIFANEPVHFPPI 755

  Fly   773 QQLLREFIQHSFKLFESTPEQNFSNISDTMETFFGCLTQIIKKIPQVLEDKTLAYDRLVFYAQRG 837
            :.|.......:..||:..|..:    .|.:::|...|.|.:::.|.:.....|....:.......
Frog   756 KSLFLLVTSLTLSLFQQGPRDH----PDIVDSFMQLLAQALRRKPCLFLSSELDVKAVFQCGVIS 816

  Fly   838 MTLPESGAIRNSIQFLTHFVMQSRNHAHVTEVVLATGEQTLYTAMMCVGYLTPRSQVDKFADILL 902
            :..||:..:::|..|...|:.:....|.|.:||...|:..|..|:..:|....|:.:|.|||||.
Frog   817 LKFPEAPTVKSSCNFFIEFLPRCGELAPVGQVVHDEGKILLQAALEGIGGQASRNHMDHFADILF 881

  Fly   903 AMNRKYAAEMAVWMKSLMSTPNFPTQLITDADKTRYTALIIKEKVNKRLLQQHLSEMAMKTRGL 966
            ::|:...|.:.||:|.:|....||:..:|...|..::..:::|:||||.::..:.:..:..|||
Frog   882 SLNKNCFAYLVVWLKEVMQQDGFPSPRLTQEQKDNFSQQVVRERVNKRRMRDMVKDFTLLCRGL 945

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cdm	NP_001262696.1	IBN_N	28..92	CDD:281761	30/63 (48%)
cdm	NP_001262696.1	Xpo1	98..>217	CDD:285575	31/123 (25%)
ipo13	XP_002931629.1	CRM1	23..>621	CDD:227432	198/644 (31%)
		IBN_N	36..97	CDD:197981	30/60 (50%)
		Xpo1	107..254	CDD:369848	37/174 (21%)
		Importin_rep	393..432	CDD:376194	20/38 (53%)
		Importin_rep_2	575..613	CDD:376205	12/37 (32%)
		Importin_rep_2	622..663	CDD:376205	10/40 (25%)
		Importin_rep_3	817..891	CDD:376225	22/73 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	75	1.000	Domainoid score	I8933
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H40968
Inparanoid	1	1.050	422	1.000	Inparanoid score	I1750
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1032285at2759
OrthoFinder	1	1.000	-	-		FOG0004114
OrthoInspector	1	1.000	-	-		oto105056
Panther	1	1.100	-	-	LDO	PTHR12363
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3916
SonicParanoid	1	1.000	-	-		X3951
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	9.190