DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cdm and ipo13b

DIOPT Version :9

Sequence 1:	NP_001262696.1	Gene:	cdm / 42171	FlyBaseID:	FBgn0261532	Length:	971	Species:	Drosophila melanogaster
Sequence 2:	XP_002665826.2	Gene:	ipo13b / 100319138	ZFINID:	ZDB-GENE-070706-1	Length:	953	Species:	Danio rerio

Alignment Length:	982	Identity:	269/982 - (27%)
Similarity:	490/982 - (49%)	Gaps:	69/982 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 IARLEEAVVS-FYRSNSQNQAITHEWLTDAEASPQAWQFSWQLMQLGKSQEVQFFGAITLHSKLM 69
            :..:|:|:.. :|..|.:|:.:..:||..|:.|||||||.|.|::..|..|:|:|||..||:|:.
Zfish    11 VENVEKALHQLYYDPNIENKNLAQKWLMQAQVSPQAWQFCWVLLRPDKVPEIQYFGASALHTKIS 75

  Fly    70 KHWHEVPPENREELKQKILESIVRFAGGPKIVLNRLCISLGAYIVHMLGE-WPGAIEEVINTFQN 133
            ::|.::|.|..:.||.::...|.|||.|.||||.|||::|.:..::|:.| ||||:.|::..||.
Zfish    76 RYWSDIPAEQYDSLKSQLFSQIARFASGSKIVLTRLCVALASLALNMMPEAWPGAVSEMVRMFQE 140

  Fly   134 QRMPNVSADVQLWIMLEVLTAIPEEAQVIH-TSVKRVVLRAEIAKRVQLVIHTVERYLKLQMNRV 197
            .. .:|....:...:||:||.:|||.|... ...::..:|..:......|...::     |:.|.
Zfish   141 DG-GDVDGRARCLALLELLTVLPEEFQTSRLPQYRKGQVRGALGSEWTAVYPLLQ-----QLLRQ 199

  Fly   198 WDAEAYSNMNRAVKCVGTWIKNIGYTIEGCVTITAVLLEVVHKCYWPCIHAGDGCMTAD-----E 257
            .|:.:.... |.:||:.:|                |||:|.       ::..:|.:.|.     :
Zfish   200 PDSPSLVKA-RVLKCLSSW----------------VLLDVP-------LNESEGLVEASFTALAD 240

  Fly   258 NELAESCLKTMVNIIIQPDCHNYPKTAFVLIKMFLDSLSEITKTEWKRENDNEDIIVHIYMLFVS 322
            .||.::.::.:||.|.|||...|..|...|:...|....::....   :|.:.:....|..:.||
Zfish   241 PELFDTAVEAIVNTISQPDSQRYVNTLLKLVPQVLQLQEQLRDAV---QNGDMETSHGICRIAVS 302

  Fly   323 SVERHSTLLLSGITSADPELSILVHRIVQEILHCTDKPGIYPVEESCSTMALAFWYMLQDEVFAM 387
            ..|.||..||..:......|:     :|..|:.||..||.|||.|:.|::.|.|||.|||::  |
Zfish   303 LGENHSRALLEQVEHWQSFLA-----LVNMIMFCTGIPGHYPVNETTSSLTLTFWYTLQDDI--M 360

  Fly   388 SNDEQKHKCW-EYIKPLYAHLTRILVRKSEQPDEKSLAKWSSDDLECFRCYRQDISDTFMYCYDV 451
            |.:.:|...: :..:|:|..|..:|:.|::.|.::..|.||||:.|.||.||.|||||.||.|::
Zfish   361 SFEAEKQAVYLQVYRPVYFQLVDVLLHKAQFPTDEEYASWSSDEKEQFRIYRVDISDTLMYVYEM 425

  Fly   452 LNDYILEILAAMLDEAIADLQRHPTHWTKLEACIYSFQSVAEHFGGEEKRQIPRLMRVLAEIPYE 516
            |...:|..|...|...:.:.:: .|.|...||.:|.|||:||.........||.|:.::..|...
Zfish   426 LGAELLSNLYDKLGRLLTNTEQ-TTTWQHTEALLYGFQSIAETIDVNYSDVIPGLIGLIPRININ 489

  Fly   517 KLNVKLLGTALETMGSYCNWLMENPAYIPPAINLLVRGL-NSSMSAQATLGLKELCRDCQLQLKP 580
              ||:|..|.:.|:|:...||.::|..:...:.|:::.| |..:|..:...||::||:|:..|.|
Zfish   490 --NVQLADTVMFTIGALAEWLADHPVMLSSVLPLVLQALGNPDLSVSSVSTLKKICRECKYDLPP 552

  Fly   581 YADPLLNACHASLNTGRMKNSDSVRLMFSIGKLMSLLRPEEIPKYLDIIVSPCFEELQAICQADS 645
            ||..::......|.....|.|..:.||.::|.|:|.|..|||.:.|..:::|..::|:.:.: ::
Zfish   553 YATNIVAVSQEVLIKQIHKTSQCMWLMQALGFLLSALPVEEILRNLHSLITPYIQQLEKLAE-ET 616

  Fly   646 KTPAARIRTIFRLNMISTLFSSLN--TDVDEQATDQPIVQ---------PVLLVMQRTMPIFKRI 699
            ..|:.::..|..|.::|.||::|:  ...||...:.|.::         ||::|:|:...:.:.:
Zfish   617 PNPSNKLAIIHILGLLSNLFTTLDITKQEDESGENAPPIKSAPPPTGPNPVVVVLQQVFALIQTV 681

  Fly   700 AEMWVEEIDVLEAACSAMKHAITNLRSSFQPMLQDLCLFIVASFQTRCCAPTLEISKTAIVMFFK 764
            ...|:.:..|:||.|:..:.::..|...|.||:..|...:...:.|...|..|::::..:.:|..
Zfish   682 LSKWLNDSQVVEAVCAIFEKSVKTLLHDFAPMVSQLSEMLGQMYSTIPQASALDLTRQMVHIFAS 746

  Fly   765 DEGCKPLMQQLLREFIQHSFKLFESTPEQNFSNISDTMETFFGCLTQIIKKIPQVLEDKTLAYDR 829
            :....|.::.|.......:..:|:..|..:    .|.:::|.....|.:|:.|.:...:.|....
Zfish   747 ETNHFPPIKALFELVTSVTLTIFQQGPRDH----PDIVDSFMQLQAQALKRKPDLFLSENLDVKA 807

  Fly   830 LVFYAQRGMTLPESGAIRNSIQFLTHFVMQSRNHAHVTEVVLATGEQTLYTAMMCVGYLTPRSQV 894
            :.......:..||:..::::..|.:..:....:...:..||...|:..|...:..:|..:.||.:
Zfish   808 VFHCGVLSLKFPEAPTVKSTCLFFSELIPHCADIPPLARVVQEDGKLLLVAVLEAIGGQSSRSLM 872

  Fly   895 DKFADILLAMNRKYAAEMAVWMKSLMSTPNFPTQLITDADKTRYTALIIKEKVNKRLLQQHLSEM 959
            |:||::|..:|:.....:.||:|..:.:|.||:..::|..|..::..:::|:||||.::..:.|.
Zfish   873 DQFAEVLFCLNKHCFTLLTVWLKEALRSPGFPSSRVSDEQKNTFSQQVLRERVNKRRVKDIVKEF 937

  Fly   960 AMKTRGL 966
            .:..|||
Zfish   938 TLVCRGL 944

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cdm	NP_001262696.1	IBN_N	28..92	CDD:281761	26/63 (41%)
cdm	NP_001262696.1	Xpo1	98..>217	CDD:285575	34/120 (28%)
ipo13b	XP_002665826.2	CRM1	8..>638	CDD:227432	205/670 (31%)
		IBN_N	33..99	CDD:197981	27/65 (42%)
		Xpo1	104..251	CDD:285575	43/176 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170575786
Domainoid	1	1.000	75	1.000	Domainoid score	I9013
eggNOG	1	0.900	-	-		E1_KOG2022
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H40968
Inparanoid	1	1.050	421	1.000	Inparanoid score	I1763
OMA	1	1.010	-	-		QHG55969
OrthoDB	1	1.010	-	-		D1032285at2759
OrthoFinder	1	1.000	-	-		FOG0004114
OrthoInspector	1	1.000	-	-		otm24537
orthoMCL	1	0.900	-	-		OOG6_104367
Panther	1	1.100	-	-	LDO	PTHR12363
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3916
SonicParanoid	1	1.000	-	-		X3951
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800