Protein Alignment wrd and PPP2R5C

DIOPT Version :9

• Sequence 1: NP_732295.1
• Gene: wrd / 42169
• FlyBaseID: FBgn0042693
• Length: 984
• Species: Drosophila melanogaster
• Sequence 2: XP_005267876.1
• Gene: PPP2R5C / 5527
• HGNCID: 9311
• Length: 584
• Species: Homo sapiens
• Alignment Length: 610
• Identity: 373/610 - (61%)
• Similarity: 455/610 - (74%)
• Gaps: 41/610 - (6%)

  Fly   366 EEMRPTVAQNLVGGISISLGIGQRNGGAAPASSAVMVTPNATMVV-TTSSLSIRQNGDILPGHPA 429
            ||:|....::...|.|   |...:.|.....|..:.|..|:.:.| :|.|..|:    :....|.
Human     7 EELRKAELESPKAGKS---GKSSKEGQDTVESEQISVRKNSLVAVPSTVSAKIK----VPVSQPI 64

  Fly   430 GLQPSPQTLQQLTGSPGRARDRNLFYTPPTASVAMALPALRETAASEREELFIQKIQQCCTLFDF 494
            ..:...|...:.:.|..|...:              ||:|::...:::|:|||||::|||.||||
Human    65 VKKDKRQNSSRFSASNNRELQK--------------LPSLKDVPPADQEKLFIQKLRQCCVLFDF 115

  Fly   495 -SEPLSDLKFKEVKRAALHEMVDFLTNQNGVITEVIYPEAINMFAVNLFRTLPPSSNPNGAEFDP 558
             |:||||||:||||||||.|||:::|:...||||.||||.::|||||:||||||||||.||||||
Human   116 VSDPLSDLKWKEVKRAALSEMVEYITHNRNVITEPIYPEVVHMFAVNMFRTLPPSSNPTGAEFDP 180

  Fly   559 EEDEPTLESSWPHLQLVYELFLRFLESPDFQPSMAKRFIDHQFVLQLLDLFDSEDPRERDFLKTV 623
            ||||||||::|||||||||.||||||||||||::||::||.:||||||:|||||||||||||||.
Human   181 EEDEPTLEAAWPHLQLVYEFFLRFLESPDFQPNIAKKYIDQKFVLQLLELFDSEDPRERDFLKTT 245

  Fly   624 LHRIYGKFLGLRAFIRKQINNVFYRFIYETEHHNGIAELLEILGSIINGFALPLKEEHKQFLLKV 688
            |||||||||||||:|||||||:|||||||||||||||||||||||||||||||||||||.|||||
Human   246 LHRIYGKFLGLRAYIRKQINNIFYRFIYETEHHNGIAELLEILGSIINGFALPLKEEHKIFLLKV 310

  Fly   689 LLPLHKAKSLSVYHPQLTYCVVQFLEKDPSLSEAVIKSLLKFWPKTHSPKEVMFLNELEELLDVI 753
            ||||||.||||||||||.||||||||||.:|:|.|:.:|||:||||||||||||||||||:||||
Human   311 LLPLHKVKSLSVYHPQLAYCVVQFLEKDSTLTEPVVMALLKYWPKTHSPKEVMFLNELEEILDVI 375

  Fly   754 EPAEFQKVMVPLFRQIAKCVSSPHFQVAERALYYWNNEYIMSLITDNSAVILPIMFPALNRNSKT 818
            ||:||.|:|.|||||:||||||||||||||||||||||||||||:||:|.|||||||:|.|||||
Human   376 EPSEFVKIMEPLFRQLAKCVSSPHFQVAERALYYWNNEYIMSLISDNAAKILPIMFPSLYRNSKT 440

  Fly   819 HWNKTIHGLIYNALKLFMEIDQRLFDECSKNYKQEKQMEREKLSQREELWQQVESLAKTNPEWTK 883
            |||||||||||||||||||::|:|||:|::.:|.||..|:.|:.:|||.|.::|:|||.||::|
Human   441 HWNKTIHGLIYNALKLFMEMNQKLFDDCTQQFKAEKLKEKLKMKEREEAWVKIENLAKANPQYT- 504

  Fly   884 ARRFNDCLPVSDSRALCDQYSENSDSAYDQSEQRARQPPPPLPPQKQAHQEPREIRGERNKDKPL 948
                    ..|.:..:....:..:|....:..|..|:     ..:.:|||..::.:    ||:||
Human   505 --------VYSQASTMSIPVAMETDGPLFEDVQMLRK-----TVKDEAHQAQKDPK----KDRPL 552

  Fly   949 LRRKSDLPSDSGTVKALNEHKRTDE 973
            .||||:||.|..|.|||..|.|.||
Human   553 ARRKSELPQDPHTKKALEAHCRADE 577

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
wrd	NP_732295.1	B56	474..875	CDD:279883	320/401 (80%)
		PLN00122	<780..879	CDD:215064	71/98 (72%)
PPP2R5C	XP_005267876.1	PLN00122	41..>153	CDD:215064	49/129 (38%)
		B56	94..497	CDD:279883	320/402 (80%)
		PLN00122	<402..502	CDD:215064	72/99 (73%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165157060
Domainoid	1	1.000	693	1.000	Domainoid score	I131
eggNOG	1	0.900	-	-		E1_KOG2085
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	733	1.000	Inparanoid score	I606
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D345293at33208
OrthoFinder	1	1.000	-	-		FOG0000226
OrthoInspector	1	1.000	-	-		otm40285
orthoMCL	1	0.900	-	-		OOG6_100293
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3
SonicParanoid	1	1.000	-	-		X167
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.690