DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment wrd and PPP2R5B

DIOPT Version :9

Sequence 1:	NP_732295.1	Gene:	wrd / 42169	FlyBaseID:	FBgn0042693	Length:	984	Species:	Drosophila melanogaster
Sequence 2:	NP_006235.1	Gene:	PPP2R5B / 5526	HGNCID:	9310	Length:	497	Species:	Homo sapiens

Alignment Length:	460	Identity:	283/460 - (61%)
Similarity:	353/460 - (76%)	Gaps:	16/460 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly   425 PGHPAGLQPSP----------QTLQQLTGSPGRARDRNLFYTPPTASVAMALPALRETAASEREE 479
            |..| ||.|.|          ::|::  ..|.|:...:.|...........||.|::..|||..|
Human    14 PSSP-GLSPVPPPDKVDGFSRRSLRR--ARPRRSHSSSQFRYQSNQQELTPLPLLKDVPASELHE 75

  Fly   480 LFIQKIQQCCTLFDFSEPLSDLKFKEVKRAALHEMVDFLTNQNGVITEVIYPEAINMFAVNLFRT 544
            |..:|:.||..:|||.:.::|||.||||||||:|:|:.:.:..||:.|.:||:.|.|.:||:|||
Human    76 LLSRKLAQCGVMFDFLDCVADLKGKEVKRAALNELVECVGSTRGVLIEPVYPDIIRMISVNIFRT 140

  Fly   545 LPPSSNPNGAEFDPEEDEPTLESSWPHLQLVYELFLRFLESPDFQPSMAKRFIDHQFVLQLLDLF 609
            ||||.||   |||||||||.||.||||||||||.|||||||||||||:|||::|.:|||.||:||
Human   141 LPPSENP---EFDPEEDEPNLEPSWPHLQLVYEFFLRFLESPDFQPSVAKRYVDQKFVLMLLELF 202

  Fly   610 DSEDPRERDFLKTVLHRIYGKFLGLRAFIRKQINNVFYRFIYETEHHNGIAELLEILGSIINGFA 674
            ||||||||::|||:|||:|||||||||:||||.|::|.|||||.||.||:|||||||||||||||
Human   203 DSEDPREREYLKTILHRVYGKFLGLRAYIRKQCNHIFLRFIYEFEHFNGVAELLEILGSIINGFA 267

  Fly   675 LPLKEEHKQFLLKVLLPLHKAKSLSVYHPQLTYCVVQFLEKDPSLSEAVIKSLLKFWPKTHSPKE 739
            ||||.||||||::||:|||..|||||:|.||.||||||||||.:|:|.||:.|||:||||.:.||
Human   268 LPLKTEHKQFLVRVLIPLHSVKSLSVFHAQLAYCVVQFLEKDATLTEHVIRGLLKYWPKTCTQKE 332

  Fly   740 VMFLNELEELLDVIEPAEFQKVMVPLFRQIAKCVSSPHFQVAERALYYWNNEYIMSLITDNSAVI 804
            ||||.|:||:||||||::|.|:..|||:|:|:|||||||||||||||:||||||:|||.||...:
Human   333 VMFLGEMEEILDVIEPSQFVKIQEPLFKQVARCVSSPHFQVAERALYFWNNEYILSLIEDNCHTV 397

  Fly   805 LPIMFPALNRNSKTHWNKTIHGLIYNALKLFMEIDQRLFDECSKNYKQEKQMEREKLSQREELWQ 869
            ||.:|..|.:.||.|||:||..||||.||.|||::.:||||.:.:||.|||.|::|..:|:||||
Human   398 LPAVFGTLYQVSKEHWNQTIVSLIYNVLKTFMEMNGKLFDELTASYKLEKQQEQQKAQERQELWQ 462

  Fly   870 QVESL 874
            .:|.|
Human   463 GLEEL 467

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wrd	NP_732295.1	B56	474..875	CDD:279883	270/401 (67%)
wrd	NP_732295.1	PLN00122	<780..879	CDD:215064	56/95 (59%)
PPP2R5B	NP_006235.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..55		10/43 (23%)
		B56	69..467	CDD:279883	269/400 (67%)
		PLN00122	<373..467	CDD:215064	55/93 (59%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	475..497
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2085
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D345293at33208
OrthoFinder	1	1.000	-	-		FOG0000226
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100293
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3
SonicParanoid	1	1.000	-	-		X167
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.750