DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment wrd and ppp2r5ea

DIOPT Version :9

Sequence 1:	NP_732295.1	Gene:	wrd / 42169	FlyBaseID:	FBgn0042693	Length:	984	Species:	Drosophila melanogaster
Sequence 2:	NP_919396.1	Gene:	ppp2r5ea / 373881	ZFINID:	ZDB-GENE-030904-7	Length:	468	Species:	Danio rerio

Alignment Length:	479	Identity:	299/479 - (62%)
Similarity:	363/479 - (75%)	Gaps:	28/479 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly   397 SSAVMVTPNATMVVTTSSLSIRQNGDILPGHPAGLQPSPQTLQQLTGSPGRARDRNLFYTPPTAS 461
            |||....|:...|...|..|:|:          ..|...|:..|.     |::|:.:
Zfish     2 SSAATTAPSVDKVDGFSRKSVRK----------ARQKRAQSSSQF-----RSQDKPI-------- 43

  Fly   462 VAMALPALRETAASEREELFIQKIQQCCTLFDFSEPLSDLKFKEVKRAALHEMVDFLTNQNGVIT 526
            ..:|||.|::.:|.|:.|||::|:|||||||||.:.|||||.||.||:.|:|:||::|...|.:|
Zfish    44 ELVALPLLKDVSAQEQPELFLKKLQQCCTLFDFMDTLSDLKMKEYKRSTLNELVDYVTLSRGYLT 108

  Fly   527 EVIYPEAINMFAVNLFRTLPPS-SNPNGAEFDPEEDEPTLESSWPHLQLVYELFLRFLESPDFQP 590
            |..|||.:.|.:.|:||||||| ||    ||||||||||||:||||||||||.|:|||||.:|||
Zfish   109 EQTYPEVVKMVSYNIFRTLPPSDSN----EFDPEEDEPTLEASWPHLQLVYEFFIRFLESQEFQP 169

  Fly   591 SMAKRFIDHQFVLQLLDLFDSEDPRERDFLKTVLHRIYGKFLGLRAFIRKQINNVFYRFIYETEH 655
            |.||::||.:||||||:|||||||||||.|||||||||||||||||||||||||:|..|:||||.
Zfish   170 SAAKKYIDQKFVLQLLELFDSEDPRERDCLKTVLHRIYGKFLGLRAFIRKQINNIFLCFVYETER 234

  Fly   656 HNGIAELLEILGSIINGFALPLKEEHKQFLLKVLLPLHKAKSLSVYHPQLTYCVVQFLEKDPSLS 720
            .||:|||||||||||||||||||.||||||:|||||||..:|||::|.||.||:||||||||:|:
Zfish   235 FNGVAELLEILGSIINGFALPLKAEHKQFLVKVLLPLHTVRSLSLFHAQLAYCIVQFLEKDPTLT 299

  Fly   721 EAVIKSLLKFWPKTHSPKEVMFLNELEELLDVIEPAEFQKVMVPLFRQIAKCVSSPHFQVAERAL 785
            |.||:.||||||||.|.||||||.||||:||||||.:|.|:...||:|||:||||||||||||||
Zfish   300 EPVIRGLLKFWPKTCSQKEVMFLGELEEILDVIEPTQFVKIQELLFKQIARCVSSPHFQVAERAL 364

  Fly   786 YYWNNEYIMSLITDNSAVILPIMFPALNRNSKTHWNKTIHGLIYNALKLFMEIDQRLFDECSKNY 850
            ||||||||||||.:|.:.||||||.:|.|.||.|||..|..||||.||.|||::..||||.:.:|
Zfish   365 YYWNNEYIMSLIEENCSAILPIMFASLYRISKEHWNPAISALIYNVLKAFMEMNSALFDELAASY 429

  Fly   851 KQEKQMEREKLSQREELWQQVESL 874
            |.::|.||:|..:||:||:::|.|
Zfish   430 KSDRQRERKKDKEREDLWRKLEDL 453

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wrd	NP_732295.1	B56	474..875	CDD:279883	282/402 (70%)
wrd	NP_732295.1	PLN00122	<780..879	CDD:215064	58/95 (61%)
ppp2r5ea	NP_919396.1	PLN00122	2..>67	CDD:215064	22/87 (25%)
		B56	55..453	CDD:279883	281/401 (70%)
		PLN00122	<359..453	CDD:215064	57/93 (61%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2085
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D345293at33208
OrthoFinder	1	1.000	-	-		FOG0000226
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100293
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X167
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.720