DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment wrd and Ppp2r5b

DIOPT Version :9

Sequence 1:	NP_732295.1	Gene:	wrd / 42169	FlyBaseID:	FBgn0042693	Length:	984	Species:	Drosophila melanogaster
Sequence 2:	NP_852044.1	Gene:	Ppp2r5b / 309179	RGDID:	727786	Length:	497	Species:	Rattus norvegicus

Alignment Length:	518	Identity:	293/518 - (56%)
Similarity:	367/518 - (70%)	Gaps:	50/518 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   425 PGHPAGLQPSP----------QTLQQLTGSPGRARDRNLFYTPPTASVAMALPALRETAASEREE 479
            |..| ||.|.|          ::|::  ..|.|:...:.|...........||.|::..|||..|
  Rat    14 PSSP-GLSPVPPPDKVDGFSRRSLRR--ARPRRSHSSSQFRYQSNQQELTPLPLLKDVPASELHE 75

  Fly   480 LFIQKIQQCCTLFDFSEPLSDLKFKEVKRAALHEMVDFLTNQNGVITEVIYPEAINMFAVNLFRT 544
            |..:|:.||..:|||.:.::|||.||||||||:|:|:.:.:..||:.|.:||:.|.|.:||:|||
  Rat    76 LLSRKLAQCGVMFDFLDCVADLKGKEVKRAALNELVECVGSTRGVLIEPVYPDIIRMISVNIFRT 140

  Fly   545 LPPSSNPNGAEFDPEEDEPTLESSWPHLQLVYELFLRFLESPDFQPSMAKRFIDHQFVLQLLDLF 609
            ||||.||   |||||||||.||.||||||||||.|||||||||||||:|||::|.:|||.||:||
  Rat   141 LPPSENP---EFDPEEDEPNLEPSWPHLQLVYEFFLRFLESPDFQPSVAKRYVDQKFVLMLLELF 202

  Fly   610 DSEDPRERDFLKTVLHRIYGKFLGLRAFIRKQINNVFYRFIYETEHHNGIAELLEILGSIINGFA 674
            ||||||||::|||:|||:|||||||||:||||.|::|.|||||.||.||:|||||||||||||||
  Rat   203 DSEDPREREYLKTILHRVYGKFLGLRAYIRKQCNHIFLRFIYELEHFNGVAELLEILGSIINGFA 267

  Fly   675 LPLKEEHKQFLLKVLLPLHKAKSLSVYHPQLTYCVVQFLEKDPSLSEAVIKSLLKFWPKTHSPKE 739
            ||||.||||||::||:|||..|||||:|.||.||||||||||.:|:|.||:.|||:||||.:.||
  Rat   268 LPLKTEHKQFLVRVLIPLHSVKSLSVFHAQLAYCVVQFLEKDATLTEHVIRGLLKYWPKTCTQKE 332

  Fly   740 VMFLNELEELLDVIEPAEFQKVMVPLFRQIAKCVSSPHFQVAERALYYWNNEYIMSLITDNSAVI 804
            ||||.|:||:||||||::|.|:..|||:|:|:|||||||||||||||:||||||:|||.||...:
  Rat   333 VMFLGEMEEILDVIEPSQFVKIQEPLFKQVARCVSSPHFQVAERALYFWNNEYILSLIEDNCHTV 397

  Fly   805 LPIMFPALNRNSKTHWNKTIHGLIYNALKLFMEIDQRLFDECSKNYKQEKQMEREKLSQREELWQ 869
            ||.:|..|.:.||.|||:||..||||.||.|||::.:||||.:.:||.|||.|::|..:|:|||:
  Rat   398 LPAVFGTLYQVSKEHWNQTIVSLIYNVLKTFMEMNGKLFDELTASYKLEKQQEQQKAQERQELWR 462

  Fly   870 QVESLAKTNPEWTKARRFNDCLPVSDSRALCDQYSENSDSAYDQSEQRARQPPPPLP-PQKQA 931
            .:|.|        :.||.                         |..|.|::.|.|.| ||..|
  Rat   463 GLEEL--------RLRRL-------------------------QGTQGAKEAPVPRPTPQVAA 492

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wrd	NP_732295.1	B56	474..875	CDD:279883	268/400 (67%)
wrd	NP_732295.1	PLN00122	<780..879	CDD:215064	55/98 (56%)
Ppp2r5b	NP_852044.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..55		10/43 (23%)
		B56	69..467	CDD:396263	268/400 (67%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	473..497		9/20 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2085
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D345293at33208
OrthoFinder	1	1.000	-	-		FOG0000226
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100293
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X167
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.720