DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment wrd and Ppp2r5e

DIOPT Version :9

Sequence 1:	NP_732295.1	Gene:	wrd / 42169	FlyBaseID:	FBgn0042693	Length:	984	Species:	Drosophila melanogaster
Sequence 2:	NP_036154.1	Gene:	Ppp2r5e / 26932	MGIID:	1349473	Length:	467	Species:	Mus musculus

Alignment Length:	479	Identity:	300/479 - (62%)
Similarity:	366/479 - (76%)	Gaps:	28/479 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly   397 SSAVMVTPNATMVVTTSSLSIRQNGDILPGHPAGLQPSPQTLQQLTGSPGRARDRNLFYTPPTAS 461
            |||....|:...|...|..|:|:          ..|...|:..|.     |::.:.:..||
Mouse     2 SSAPTTPPSVDKVDGFSRKSVRK----------ARQKRSQSSSQF-----RSQGKPIELTP---- 47

  Fly   462 VAMALPALRETAASEREELFIQKIQQCCTLFDFSEPLSDLKFKEVKRAALHEMVDFLTNQNGVIT 526
                ||.|::...||:.|||::|:||||.:|||.:.|||||.||.||:.|:|:||::|...|.:|
Mouse    48 ----LPLLKDVPTSEQPELFLKKLQQCCVIFDFMDTLSDLKMKEYKRSTLNELVDYITISRGCLT 108

  Fly   527 EVIYPEAINMFAVNLFRTLPPS-SNPNGAEFDPEEDEPTLESSWPHLQLVYELFLRFLESPDFQP 590
            |..|||.:.|.:.|:||||||| ||    ||||||||||||:||||||||||.|:|||||.:|||
Mouse   109 EQTYPEVVRMVSCNIFRTLPPSDSN----EFDPEEDEPTLEASWPHLQLVYEFFIRFLESQEFQP 169

  Fly   591 SMAKRFIDHQFVLQLLDLFDSEDPRERDFLKTVLHRIYGKFLGLRAFIRKQINNVFYRFIYETEH 655
            |:||::||.:||||||:|||||||||||:|||||||||||||||||||||||||:|.||:|||||
Mouse   170 SIAKKYIDQKFVLQLLELFDSEDPRERDYLKTVLHRIYGKFLGLRAFIRKQINNIFLRFVYETEH 234

  Fly   656 HNGIAELLEILGSIINGFALPLKEEHKQFLLKVLLPLHKAKSLSVYHPQLTYCVVQFLEKDPSLS 720
            .||:|||||||||||||||||||.||||||:|||:|||..:|||::|.||.||:||||||||||:
Mouse   235 FNGVAELLEILGSIINGFALPLKAEHKQFLVKVLIPLHTVRSLSLFHAQLAYCIVQFLEKDPSLT 299

  Fly   721 EAVIKSLLKFWPKTHSPKEVMFLNELEELLDVIEPAEFQKVMVPLFRQIAKCVSSPHFQVAERAL 785
            |.||:.|:||||||.|.||||||.||||:||||||::|.|:..|||:||||||||||||||||||
Mouse   300 EPVIRGLMKFWPKTCSQKEVMFLGELEEILDVIEPSQFVKIQEPLFKQIAKCVSSPHFQVAERAL 364

  Fly   786 YYWNNEYIMSLITDNSAVILPIMFPALNRNSKTHWNKTIHGLIYNALKLFMEIDQRLFDECSKNY 850
            ||||||||||||.:||.|||||||.:|.|.||.|||..|..|:||.||.|||::..:|||.:..|
Mouse   365 YYWNNEYIMSLIEENSNVILPIMFSSLYRISKEHWNPAIVALVYNVLKAFMEMNSTMFDELTATY 429

  Fly   851 KQEKQMEREKLSQREELWQQVESL 874
            |.::|.|::|..:|||||:::|.|
Mouse   430 KSDRQREKKKEKEREELWKKLEDL 453

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wrd	NP_732295.1	B56	474..875	CDD:279883	283/402 (70%)
wrd	NP_732295.1	PLN00122	<780..879	CDD:215064	58/95 (61%)
Ppp2r5e	NP_036154.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..39		12/51 (24%)
		B56	2..>67	CDD:421517	22/87 (25%)
		B56	55..435	CDD:396263	273/383 (71%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2085
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D345293at33208
OrthoFinder	1	1.000	-	-		FOG0000226
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100293
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3
SonicParanoid	1	1.000	-	-		X167
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.750