DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment wrd and par2

DIOPT Version :9

Sequence 1:	NP_732295.1	Gene:	wrd / 42169	FlyBaseID:	FBgn0042693	Length:	984	Species:	Drosophila melanogaster
Sequence 2:	NP_593298.1	Gene:	par2 / 2542891	PomBaseID:	SPAC6F12.12	Length:	627	Species:	Schizosaccharomyces pombe

Alignment Length:	570	Identity:	244/570 - (42%)
Similarity:	362/570 - (63%)	Gaps:	41/570 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly   316 NATKSVGTSAAAAAAAAATSSSSSPSSAAAVPSSAATAVAAVPTTSDVPAEEMRPTVAQNLVGGI 380
            |:.|.:.|:..|:....:..|:..|    .:.:|........|.....|..:
pombe    85 NSDKKIHTTVLASGHEDSDYSTFLP----VIETSKVKDANHFPPNYPEPKND------------- 132

  Fly   381 SISLGIGQRNGGAAPASSAVMVTPNATMVVTTSS-------LSIRQNGDILPGHPAGLQPSPQTL 438
            |:|..|.:....:..::|.:.| |.:|.....|.       |:..:|.||    |..|:|.|:
pombe   133 SVSSNIDEFPNDSISSASFLSV-PQSTPPYLVSQPTPLNKFLAGAENVDI----PHSLRPVPR-- 190

  Fly   439 QQLTGSPGRARDRNLFYTPPTASVAMALPALRETAASEREELFIQKIQQCCTLFDFSEPLSDLKF 503
                      |:.:..:........:.||:..:...||||||||:|::||..:|||::|.|||..
pombe   191 ----------REHSSQFQVSEKRTLVRLPSFDDVHTSEREELFIKKLEQCNIIFDFNDPSSDLAS 245

  Fly   504 KEVKRAALHEMVDFLTNQNGVITEVIYPEAINMFAVNLFRTLPPSSNPNGAEFDPEEDEPTLESS 568
            ||:||.||.:|:|:::...|:.:..::|..:|.|::|:||.:.|:.|...::....:|||.||.:
pombe   246 KEIKREALLQMIDYVSENRGISSASLFPYVVNTFSLNVFRPISPALNDYSSDMFALDDEPFLEPA 310

  Fly   569 WPHLQLVYELFLRFLESPDFQPSMAKRFIDHQFVLQLLDLFDSEDPRERDFLKTVLHRIYGKFLG 633
            ||||:.||.||::|||||||:.|.||..:|.:|..:||.|||:||||||:.|||.|||||||||.
pombe   311 WPHLEEVYLLFIKFLESPDFRASKAKSLVDRRFFNRLLALFDTEDPRERELLKTTLHRIYGKFLN 375

  Fly   634 LRAFIRKQINNVFYRFIYETEHHNGIAELLEILGSIINGFALPLKEEHKQFLLKVLLPLHKAKSL 698
            ||::|||.:||||.:||||.|..:|||||||||||||||||:|||||||.||.|||:|||:.||:
pombe   376 LRSYIRKSMNNVFLQFIYEREKFHGIAELLEILGSIINGFAVPLKEEHKIFLSKVLIPLHQTKSV 440

  Fly   699 SVYHPQLTYCVVQFLEKDPSLSEAVIKSLLKFWPKTHSPKEVMFLNELEELLDVIEPAEFQKVMV 763
            .:||||||||:|||::|||||::||:..:||:||:.:|.||::||||:|::.:|:||:||..:|.
pombe   441 FLYHPQLTYCIVQFIDKDPSLTKAVLTGILKYWPRINSFKELLFLNEIEDIFEVLEPSEFVNIMS 505

  Fly   764 PLFRQIAKCVSSPHFQVAERALYYWNNEYIMSLITDNSAVILPIMFPALNRNSKTHWNKTIHGLI 828
            |||:|:|:.:||.|||||||||..|:|||..||::.|...:|||::|:|.:.:..|||.||..:.
pombe   506 PLFQQLARSISSMHFQVAERALCLWSNEYFTSLVSQNVVTLLPIIYPSLYKTANEHWNSTIQAIA 570

  Fly   829 YNALKLFMEIDQRLFDECSKNYKQEKQMEREKLSQREELWQQVESLAKTN 878
            .|.|::|:::|...|:...::|||....:.|.:..|::.|.|:|:||..|
pombe   571 CNVLQIFVDMDADFFNGLVEDYKQAIIKQEEVMIIRKQQWCQIEALAAEN 620

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wrd	NP_732295.1	B56	474..875	CDD:279883	213/400 (53%)
wrd	NP_732295.1	PLN00122	<780..879	CDD:215064	39/99 (39%)
par2	NP_593298.1	PLN00122	174..>227	CDD:215064	18/68 (26%)
		B56	217..617	CDD:279883	213/399 (53%)
		PLN00122	<522..624	CDD:215064	39/99 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2085
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H37661
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000226
OrthoInspector	1	1.000	-	-		mtm9255
orthoMCL	1	0.900	-	-		OOG6_100293
Panther	1	1.100	-	-	O	PTHR10257
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X167
TreeFam	1	0.960	-	-
	9	8.770