DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment wrd and Ppp2r5a

DIOPT Version :9

Sequence 1:	NP_732295.1	Gene:	wrd / 42169	FlyBaseID:	FBgn0042693	Length:	984	Species:	Drosophila melanogaster
Sequence 2:	NP_659129.2	Gene:	Ppp2r5a / 226849	MGIID:	2388479	Length:	486	Species:	Mus musculus

Alignment Length:	474	Identity:	289/474 - (60%)
Similarity:	368/474 - (77%)	Gaps:	13/474 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly   401 MVTPNATMVVTTSSLSIRQNGDILPGHPAGLQPSPQTLQQLTGSPGRARDRNLFYTPPTASVAMA 465
            |.:|:....|..:::|..:..|      ...:.|.:..|:...|.|.::    |.:..:.:....
Mouse     1 MSSPSPPAPVACAAISASEKVD------GFTRKSVRKAQRQKRSQGSSQ----FRSQGSQAELHP 55

  Fly   466 LPALRETAASEREELFIQKIQQCCTLFDFSEPLSDLKFKEVKRAALHEMVDFLTNQNGVITEVIY 530
            ||.|::..::|::|||.||:||||.||||.:.:||||.||:|||.|:|:|::::...|||.|..|
Mouse    56 LPQLKDATSNEQQELFCQKLQQCCVLFDFMDSVSDLKSKEIKRATLNELVEYVSTNRGVIVESAY 120

  Fly   531 PEAINMFAVNLFRTLPPSSNPNGAEFDPEEDEPTLESSWPHLQLVYELFLRFLESPDFQPSMAKR 595
            .:.:.|.:.|:|||||||.||   :|||||||||||:||||:|||||.|||||||||||||:|||
Mouse   121 SDIVKMISANIFRTLPPSDNP---DFDPEEDEPTLEASWPHIQLVYEFFLRFLESPDFQPSIAKR 182

  Fly   596 FIDHQFVLQLLDLFDSEDPRERDFLKTVLHRIYGKFLGLRAFIRKQINNVFYRFIYETEHHNGIA 660
            :||.:||.|||:|||||||||||||||||||||||||||||||||||||:|.||||||||.||:|
Mouse   183 YIDQKFVQQLLELFDSEDPRERDFLKTVLHRIYGKFLGLRAFIRKQINNIFLRFIYETEHFNGVA 247

  Fly   661 ELLEILGSIINGFALPLKEEHKQFLLKVLLPLHKAKSLSVYHPQLTYCVVQFLEKDPSLSEAVIK 725
            ||||||||||||||||||.||||||:|||:|:|.||.|:::|.||.||||||||||.:|:|.||:
Mouse   248 ELLEILGSIINGFALPLKAEHKQFLMKVLIPMHTAKGLALFHAQLAYCVVQFLEKDTTLTEPVIR 312

  Fly   726 SLLKFWPKTHSPKEVMFLNELEELLDVIEPAEFQKVMVPLFRQIAKCVSSPHFQVAERALYYWNN 790
            .||||||||.|.||||||.|:||:||||||.:|:|:..|||:||:|||||.||||||||||:|||
Mouse   313 GLLKFWPKTCSQKEVMFLGEIEEILDVIEPTQFKKIEEPLFKQISKCVSSSHFQVAERALYFWNN 377

  Fly   791 EYIMSLITDNSAVILPIMFPALNRNSKTHWNKTIHGLIYNALKLFMEIDQRLFDECSKNYKQEKQ 855
            |||:|||.:|...||||||.:|.:.||.|||:||..|:||.||..||::.:|||:.:.:||.|:|
Mouse   378 EYILSLIEENIDKILPIMFASLYKISKEHWNQTIVALVYNVLKTLMEMNGKLFDDLTSSYKAERQ 442

  Fly   856 MEREKLSQREELWQQVESL 874
            .|::|..:|||||:::|.|
Mouse   443 REKKKELEREELWKKLEEL 461

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wrd	NP_732295.1	B56	474..875	CDD:279883	276/401 (69%)
wrd	NP_732295.1	PLN00122	<780..879	CDD:215064	54/95 (57%)
Ppp2r5a	NP_659129.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	22..52		6/39 (15%)
		B56	64..461	CDD:279883	275/399 (69%)
		PLN00122	<351..466	CDD:215064	67/111 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2085
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000226
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100293
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3
SonicParanoid	1	1.000	-	-		X167
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.740