DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sr and klf11

DIOPT Version :9

Sequence 1:	NP_001262693.1	Gene:	sr / 42162	FlyBaseID:	FBgn0003499	Length:	1271	Species:	Drosophila melanogaster
Sequence 2:	XP_012818552.1	Gene:	klf11 / 733909	XenbaseID:	XB-GENE-956858	Length:	500	Species:	Xenopus tropicalis

Alignment Length:	414	Identity:	111/414 - (26%)
Similarity:	153/414 - (36%)	Gaps:	82/414 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   752 QQLPSPQLGVLAGPMSPPSNSLGNSWGLPSPDKTMFQPPLFSLPAHYATMQQQQQQQQQQQQQQQ 816
            ||||.....:....|:||.          ||:   |..|..:|||      ..|....:......
Frog    80 QQLPKDYHSISMLCMTPPR----------SPE---FAEPCTTLPA------ASQVTYSKPVTVMS 125

  Fly   817 QQQAAGA---------------APSPYDD----GRAAAAAAAQHAELLGLTMDCTPLLLKQPPPS 862
            ...|...               ||||..:    .||.|.:..:|      |.|.:|......||:
Frog   126 SSSACSVSSSVVYKPLVSSIPRAPSPAVEVCKPCRAMATSVIRH------TADSSPFRRIPEPPA 184

  Fly   863 YAGASA--------GFPGLGDLHSSHEQQLQQQQ-----YVRSQPKYQWLDSPADYAQQQQQVQQ 914
            .|.|.|        ..|.    ||...::....|     ..|.|||:....:..  |..||.|..
Frog   185 QAKAPAPKCTAEKKHKPD----HSKPPEEAPAPQNPSHTLHRPQPKHPCTGNTE--AGNQQPVAF 243

  Fly   915 VQQQQQQQQTLVLPGPTSSASSSNAALGVLIPKQEN--------YPDMQPSSNGTG--YSGGSGG 969
            ...|.::...|:   |.|...||:..|..:||....        .|..||.||...  ....|..
Frog   244 ENDQPKEANQLL---PISVPVSSSPLLCQMIPVTGQAGVISAFIKPPSQPISNTVKPILPQSSPV 305

  Fly   970 SSAAAAAAAAAAAAAVQLAEYSP---STSKGHEILSQVYQQSTVPLKLVPVKPRKYPNRPSKTPV 1031
            |......|..:..|.:.:...:|   |..:..:.|..|.....:||...||......:.|.:...
Frog   306 SQPVLMGAPVSQGALMLVLPQAPIPQSPQQCPQTLVAVGNTKLLPLAPAPVFIASGQSSPPQMDF 370

  Fly  1032 -HERPYACPVENCDRRFSRSDELTRHIRIHTGQKPFQCRI--CMRSFSRSDHLTTHIRTHTGEKP 1093
             ..|.|.|....|.:.:.:|..|..|:|.|||:|||.|..  |.:.|:|||.|:.|.|||||||.
Frog   371 SRRRNYVCNFSGCRKTYFKSSHLKAHLRTHTGEKPFSCNWEGCDKKFARSDELSRHRRTHTGEKK 435

  Fly  1094 FSCDICGRKFARSDEKKRHAKVHL 1117
            |:|.:|.|:|.|||...:||:.|:
Frog   436 FACPVCDRRFMRSDHLTKHARRHM 459

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sr	NP_001262693.1	zf-C2H2	1036..1060	CDD:278523	7/23 (30%)
		C2H2 Zn finger	1038..1060	CDD:275368	6/21 (29%)
		zf-H2C2_2	1052..1077	CDD:290200	12/26 (46%)
		C2H2 Zn finger	1068..1088	CDD:275368	9/21 (43%)
		zf-H2C2_2	1080..1105	CDD:290200	14/24 (58%)
		C2H2 Zn finger	1096..1116	CDD:275368	9/19 (47%)
klf11	XP_012818552.1	PHA03247	<95..366	CDD:223021	65/304 (21%)
		COG5048	360..>431	CDD:227381	25/70 (36%)
		C2H2 Zn finger	381..400	CDD:275368	5/18 (28%)
		C2H2 Zn finger	408..430	CDD:275368	9/21 (43%)
		zf-H2C2_2	422..445	CDD:372612	13/22 (59%)
		zf-C2H2	436..458	CDD:333835	10/21 (48%)
		C2H2 Zn finger	438..458	CDD:275368	9/19 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2698
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	2.030