DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sr and SP2

DIOPT Version :9

Sequence 1:	NP_001262693.1	Gene:	sr / 42162	FlyBaseID:	FBgn0003499	Length:	1271	Species:	Drosophila melanogaster
Sequence 2:	XP_011523438.1	Gene:	SP2 / 6668	HGNCID:	11207	Length:	771	Species:	Homo sapiens

Alignment Length:	891	Identity:	163/891 - (18%)
Similarity:	247/891 - (27%)	Gaps:	379/891 - (42%)

- Green bases have known domain annotations that are detailed below.

  Fly   319 KTSTAAQSSGSPSTATYLSPAQFGGSHHGGASTSSNSLNSSSTASSSSTSSSLLHYTTASAAAAA 383
            :||.||.::.|||  .||.||                   :||...|..|...|...|.|.....
Human   109 QTSMAATAAVSPS--DYLQPA-------------------ASTTQDSQPSPLALLAATCSKIGPP 152

  Fly   384 AAAAAASANNSVLRARNQTATPTQGGSPGHVAVQPS-ATASSGRSS--------------ASHLS 433
            |..||.:           ...|.|......|.::|: ...|.|::|              .|.||
Human   153 AVEAAVT-----------PPAPPQPTPRKLVPIKPAPLPLSPGKNSFGILSSKGNILQIQGSQLS 206

  Fly   434 LLNTSGQ-----HSPTS-------------SAVEQVEAHK-----------QLIEALPGDLNTPV 469
            .....||     .:||.             .||.|::|..           ..|:.:||.....:
Human   207 ASYPGGQLVFAIQNPTMINKGTRSNANIQYQAVPQIQASNSQTIQVQPNLTNQIQIIPGTNQAII 271

  Fly   470 TTSSDIPSFFGPTTVVEPP-------------------------------PITGSIESEDLSLEP 503
            |.|   ||...|..:...|                               |:...:.:.|.....
Human   272 TPS---PSSHKPVPIKPAPIQKSSTTTTPVQSGANVVKLTGGGGNVTLTLPVNNLVNASDTGAPT 333

  Fly   504 QVISVASPV-LSHCSPLKEERSTP---PALAIVKEESSNNSCNMYPQHNNNNNNNNNTTSSSTTT 564
            |:::.:.|. ||..:....::|.|   |.:|:.::..                     |....||
Human   334 QLLTESPPTPLSKTNKKARKKSLPASQPPVAVAEQVE---------------------TVLIETT 377

  Fly   565 TSKQTTSESNTECVGSPGNHTQSHQQQQQQLQHNNTSSSNSNCHHSHQQQQQQQQQQHMSSPQQQ 629
            ......:.:|...|.|||.
Human   378 ADNIIQAGNNLLIVQSPGG---------------------------------------------- 396

  Fly   630 YQQHQILHQQQQLPNHHHHHHHHHHHHSQLQQLQQQQQQQQQQQQHQQQPLHQQQQLQHQQQQQH 694
             .|..::.|.|.:|                     .:.:|||..|..||.|...|
Human   397 -GQPAVVQQVQVVP---------------------PKAEQQQVVQIPQQALRVVQ---------- 429

  Fly   695 HQQHYQQHAIQHQQSQQQASKISYRGIFTTTGNAMNAAAAAAAAAAQQQHQQQQQHQQQLPSPQL 759
                                                 ||:|......|:..|..|.|...|:|..
Human   430 -------------------------------------AASATLPTVPQKPSQNFQIQAAEPTPTQ 457

  Fly   760 GVLAGPM----------SPPSNSLGNSWGLPSPDKTMFQPPLFSLPAHYATMQQQQQQQQQQQQQ 814
            ..:..|.          |||:.:...|       .|....|....|....|.::......::::.
Human   458 VYIRTPSGEVQTVLVQDSPPATAAATS-------NTTCSSPASRAPHLSGTSKKHSAAILRKERP 515

  Fly   815 QQQQQAAGAAPSPYDDGRAAAAAAAQHAELLGLTMDCTPLLLKQPPPSYAGASAGFPGLGDLHSS 879
            ..:...||:..|......||||.|.|...:.|:.:...|:.:                   .::.
Human   516 LPKIAPAGSIISLNAAQLAAAAQAMQTININGVQVQGVPVTI-------------------TNTG 561

  Fly   880 HEQQLQQQQYVRSQPKYQWLDSPADYAQQQQQVQQVQQQQQQQQTLVLPGPTSSASSSNAALGVL 944
            .:|||..|....:......| ||.          |:|.|.:|    .|.|.|....
Human   562 GQQQLTVQNVSGNNLTISGL-SPT----------QIQLQMEQ----ALAGETQPGE--------- 602

  Fly   945 IPKQENYPDMQPS-SNGTGYSGGSGGSSAAAAAAAAAAAAAVQLAEYSPSTSKGHEILSQVYQQS 1008
              |:.......|: .:|...||..|
Human   603 --KRRRMACTCPNCKDGEKRSGEQG---------------------------------------- 625

  Fly  1009 TVPLKLVPVKPRKYPNRPSKTPVHERPYACPVENCDRRFSRSDELTRHIRIHTGQKPFQCR--IC 1071
                                    ::.:.|.:.:|.:.|.::..|..|:|:|||::||.|.  .|
Human   626 ------------------------KKKHVCHIPDCGKTFRKTSLLRAHVRLHTGERPFVCNWFFC 666

  Fly  1072 MRSFSRSDHLTTHIRTHTGEKPFSCDICGRKFARSDEKKRHAKVHL 1117
            .:.|:|||.|..|.|||||:|.|.|..|.::|.|||...:|.|.||
Human   667 GKRFTRSDELQRHARTHTGDKRFECAQCQKRFMRSDHLTKHYKTHL 712

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sr	NP_001262693.1	zf-C2H2	1036..1060	CDD:278523	6/23 (26%)
		C2H2 Zn finger	1038..1060	CDD:275368	6/21 (29%)
		zf-H2C2_2	1052..1077	CDD:290200	11/26 (42%)
		C2H2 Zn finger	1068..1088	CDD:275368	9/21 (43%)
		zf-H2C2_2	1080..1105	CDD:290200	12/24 (50%)
		C2H2 Zn finger	1096..1116	CDD:275368	8/19 (42%)
SP2	XP_011523438.1	COG5048	<553..718	CDD:227381	57/269 (21%)
		zf-C2H2	629..653	CDD:278523	6/23 (26%)
		C2H2 Zn finger	634..653	CDD:275368	5/18 (28%)
		zf-H2C2_2	646..672	CDD:290200	11/25 (44%)
		C2H2 Zn finger	661..683	CDD:275368	9/21 (43%)
		zf-H2C2_2	675..698	CDD:290200	11/22 (50%)
		zf-C2H2	689..711	CDD:278523	9/21 (43%)
		C2H2 Zn finger	691..711	CDD:275368	8/19 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2698
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.030