Protein Alignment sr and zic2a

DIOPT Version :10

• Sequence 1: NP_001262693.1
• Gene: sr / 42162
• FlyBaseID: FBgn0003499
• Length: 1271
• Species: Drosophila melanogaster
• Sequence 2: NP_571633.1
• Gene: zic2a / 58077
• ZFINID: ZDB-GENE-000710-4
• Length: 445
• Species: Danio rerio
• Alignment Length: 570
• Identity: 116/570 - (20%)
• Similarity: 179/570 - (31%)
• Gaps: 229/570 - (40%)

  Fly   740 AQQQHQQQQQHQQQL--------PSPQLGV--LAGPMSPPSNSLGNSWGLPSPDKTMFQPPLFSL 794
            |:..|...:...:.|        .|..:|.  |...:||..:|...|   .:|..     |..:|
Zfish    18 ARHHHSSSEMQDRDLSLAQNSFVDSAHMGAFKLNHDLSPGQSSAFTS---QAPGY-----PAAAL 74

  Fly   795 PAHYATMQQQQQQQQQQQQQQQQQQAAGAAPSPYDDGR----------AAAAAAAQHAELLGLTM 849
            .||.|                   .....|.||::..|          .::.|..||| |.|.|
Zfish    75 GAHAA-------------------HVTSYASSPFNSTRDFLFRSRGFGESSPAGGQHA-LFGPT- 118

  Fly   850 DCTPLLLKQPPPSYAGA-------SAG---FPGLGDLHSSHEQQLQQQQYVRSQPKYQWLDSPAD 904
                          ||:       |.|   |||:.:.|.||.........:|       |..|.:
Zfish   119 --------------AGSLHHSHTDSQGHILFPGIHEQHGSHGSPNVLNGQMR-------LGLPGE 162

  Fly   905 YAQQQQQVQQVQQQQQQQQTLVLPGPTSSA------SSSNAALGVLIPKQENYPDMQPSSNGTGY 963
            ...:..|..||...:..        |.|:|      .|.|..:|:.:....::|       |..:
Zfish   163 VFGRSDQYHQVSSPRTD--------PYSAAQLHNQYGSMNMNMGMNMAAHHHHP-------GAFF 212

  Fly   964 SGGSGGSSAAAAAAAAAAAAAVQLAEYSPSTSKGHEILSQVYQQSTVPLKLVPVK---PRKYPNR 1025
                                              ..:..|..:|..:...:.|.:   |:|..|:
Zfish   213 ----------------------------------RYMRQQCIKQELICKWIDPEQLSNPKKSCNK 243

  Fly  1026 PSKTPVHE---------------RPYACPVENCDRR---FSRSDELTRHIRIHTGQKPFQCRI-- 1070
            ...| :||               ..:.|..|.|.|.   |....:|..|||:|||:|||.|..
Zfish   244 TFST-MHELVTHVSVEHVGGPEQSNHICFWEECPRESKPFKAKYKLVNHIRVHTGEKPFPCPFPG 307

  Fly  1071 CMRSFSRSDHLTTHIRTHTGEKPFSCDI--CGRKFARSDEKKRHAKVHLKQRIKKEKVRGEQQQQ 1133
            |.:.|:||::|..|.|||||||||.|:.  |.|:||.|.::|:|..||...:
Zfish   308 CGKVFARSENLKIHKRTHTGEKPFQCEFEGCDRRFANSSDRKKHMHVHTSDK------------- 359

  Fly  1134 QQQQQQQQQQQQQQQLQQQQEQHHLSLQQHQQYQQHHLLHSADLAIVTSSASMXRLENSASSVDQ 1198
                      ....::..:...|..||::|.:                              |.:
Zfish   360 ----------PYLCKMCDKSYTHPSSLRKHMK------------------------------VHE 384

  Fly  1199 AQTPTPTPAPAATQKVSLALALDLDESAFPFELTSDYGTLSPLTSPRQFN 1248
            :..|....:|||:.               .:|.::..|.:||.|..:..|
Zfish   385 SSPPASDSSPAASS---------------GYESSTPPGLVSPSTETQSNN 419

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sr	NP_001262693.1	zf-C2H2	1036..1060	CDD:395048	9/26 (35%)
		C2H2 Zn finger	1038..1060	CDD:275368	9/24 (38%)
		zf-H2C2_2	1052..1077	CDD:463886	13/26 (50%)
		C2H2 Zn finger	1068..1088	CDD:275368	8/21 (38%)
		zf-H2C2_2	1080..1105	CDD:463886	15/26 (58%)
		C2H2 Zn finger	1096..1116	CDD:275368	8/21 (38%)
zic2a	NP_571633.1	zf_ZIC	218..263	CDD:436441	9/45 (20%)
		C2H2 Zn finger	275..295	CDD:275368	7/19 (37%)
		SFP1	<297..381	CDD:227516	34/106 (32%)
		C2H2 Zn finger	303..325	CDD:275368	8/21 (38%)
		C2H2 Zn finger	333..355	CDD:275368	8/21 (38%)
		C2H2 Zn finger	363..383	CDD:275368	4/49 (8%)