DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sr and Spps

DIOPT Version :9

Sequence 1:	NP_001262693.1	Gene:	sr / 42162	FlyBaseID:	FBgn0003499	Length:	1271	Species:	Drosophila melanogaster
Sequence 2:	NP_001262902.1	Gene:	Spps / 42882	FlyBaseID:	FBgn0039169	Length:	985	Species:	Drosophila melanogaster

Alignment Length:	1004	Identity:	228/1004 - (22%)
Similarity:	336/1004 - (33%)	Gaps:	325/1004 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   274 PGTPSAAMIMEGLETLVAPTHHAFLLTETAAAAHFNVLSFDTCLFKTSTAAQSSGSPSTAT---- 334
            |.||.||   .|......|.:.|     :|||:.                .|..|:|.|.|
  Fly    16 PATPLAA---GGSSKATIPPNGA-----SAAASQ----------------TQVHGAPGTPTMQQI 56

  Fly   335 ---YLSPAQF-GGSHHGGASTSSNSLN--------SSSTASSSSTSSSLLHYTTASAAAAAAA-- 385
               :..|.|| ||:..|....:....|        ...|.:.....:..:....|..|.|.|.
  Fly    57 INIHQMPPQFAGGAVAGNGQNAGMPQNMFQIVQPMPMQTVNIDGQEAIFIPNLNAQLATAQAVNF 121

  Fly   386 ---AAAASANNSVLRARNQTATPTQGGSPGHVAVQPSATASSGRSSASHLSLLNTSGQHSPTSSA 447
               .|..:.|..:|||....|.|....     .:|.......|:.....:::..|:.| .|.::.
  Fly   122 NGQQAFITPNGQILRAPQMAANPAASN-----CIQLQQLNGLGQEQTQLITIPGTNIQ-IPVTNL 180

  Fly   448 VEQVEAHKQLIEA---------------------------LPGDLNTPVTTSSDIPSFFGPTTVV 485
            ::|.:..:|:.:.                           |||.:..|.|....      ||:|.
  Fly   181 IQQQQQAQQVHQGTVQQQAQGTNASGANGSGVTNSGTAGQLPGSITIPGTNLQI------PTSVA 239

  Fly   486 EPPPITGSI---------------ESEDLSLEPQVISVASPVLSHCSPLKEERSTPPALAIVKEE 535
            ....:.|:|               |:..|.:.||::...:|.:    |.:::     .:|:....
  Fly   240 AANGLLGNISNISNLLGGGQSIKLENGQLQMRPQLVQFPAPAM----PQQQQ-----TVAVQIPV 295

  Fly   536 SSNNSCNMYPQHNNNNNNNNNTTSSSTTTTSKQTTSESNTECVGSPGNHTQSHQQQQQQLQHNNT 600
            .:.|...:|                .|.....|..:.|:    |...|     ..|.|.||..:.
  Fly   296 QTANGQTIY----------------QTVHVPVQAAATSS----GGLQN-----LMQAQSLQMPSA 335

  Fly   601 SSSNSNCHHSHQQQ--QQQQQQQHMSSPQQQYQQHQILHQQQQLPNHHHHHHHHHHHHSQLQQLQ 663
            |          |.|  .|..|...:.:|..|.||.|:.....|||.:.:..|..:.|..|.||:|
  Fly   336 S----------QMQIIPQFSQIAQIVTPNGQIQQVQLAMPYPQLPPNANIIHIQNPHQQQQQQVQ 390

  Fly   664 QQQQQQQQQQQHQQQPLHQQQQLQHQQQQQHHQQHYQQHAIQHQQSQQQASKISYRG-------- 720
            |||||||.|||.|.    ||||.|.|||||..        .||||..|..|..|..|
  Fly   391 QQQQQQQAQQQQQA----QQQQAQQQQQQQVQ--------AQHQQLLQAISDASAGGQLPPNQPI 443

  Fly   721 -IFTTTGNAM---------NAAAAAAAAAAQQQHQQQQQHQQQLP---SPQLG---VLAGPMSPP 769
             |....|..:         ||..|...|.|......|..:.|.||   .|.||   ::.....||
  Fly   444 TITNAQGQQLTVIPAQLRPNAPTAPTPAPAGVPTPMQMPNLQALPIQNIPGLGQVQIIHANQLPP 508

  Fly   770 SNSLGNSWGLPSPDKTMFQPPLFSLPAHYATMQQQQQQQQQQQQQQQQQQAAGAAPSPYDDGRAA 834
            :        ||:    .||..|..||..:..:|.|.|.|...:|:.|         ||
  Fly   509 N--------LPA----NFQQVLTQLPMSHPQVQTQGQVQVMPKQEPQ---------SP------- 545

  Fly   835 AAAAAQHAELLGLTMDCTPLL--LKQPPPSYAG---ASAGFPGLGDLHSSHEQQLQQQQYVRSQP 894
                             |.::  :||.||...|   |:...|......::...|.||.:::.::.
  Fly   546 -----------------TQMITSIKQEPPDTFGPISATGNPPAPASTPNTASPQQQQIKFLHTES 593

  Fly   895 -KYQWLDSPADYAQQQQQVQQVQQQ----------------------------QQQQQTLVLP-- 928
             ....|..||..     |:..:.||                            ....|..:.|
  Fly   594 NSLSSLSIPASI-----QITALPQQATNTPNTPATTQPIPVSLPARSKVNAVTTSSTQITIAPTG 653

  Fly   929 -----------GPTSSASSSNAALGVLIPKQENYPDMQPS--SNGTGYSGGSGGSSAAAAAAAAA 980
                       |.|:|..|:|.:...:....:::.:|..|  |.|...:||.||::.........
  Fly   654 GQVVSVTTQARGATASIRSTNTSTTTITTPSQSHLNMNISVASVGGAATGGGGGTATGEPKPRLK 718

  Fly   981 AAAAVQLAEYSPSTSKGHEILSQVYQQSTVPLKLVPVKPRKYPNRPSKTPVHERPYACPVENCDR 1045
            ..|..     .|:.:.|                      .|:.::       :|.:.|.:..|.:
  Fly   719 RVACT-----CPNCTDG----------------------EKHSDK-------KRQHICHITGCHK 749

  Fly  1046 RFSRSDELTRHIRIHTGQKPFQC--RICMRSFSRSDHLTTHIRTHTGEKPFSCDICGRKFARSDE 1108
            .:.::..|..|:|.|||::||.|  ..|.:.|:|||.|..|.|||||||.|.|..|.:||.|||.
  Fly   750 VYGKTSHLRAHLRWHTGERPFVCSWAFCGKRFTRSDELQRHRRTHTGEKRFQCQECNKKFMRSDH 814

  Fly  1109 KKRHAKVHLKQR---------IKKEKVRG 1128
            ..:|.|.|.|.|         ||:|...|
  Fly   815 LSKHIKTHFKSRSGVELIELSIKQETKGG 843

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sr	NP_001262693.1	zf-C2H2	1036..1060	CDD:278523	5/23 (22%)
		C2H2 Zn finger	1038..1060	CDD:275368	5/21 (24%)
		zf-H2C2_2	1052..1077	CDD:290200	11/26 (42%)
		C2H2 Zn finger	1068..1088	CDD:275368	9/21 (43%)
		zf-H2C2_2	1080..1105	CDD:290200	14/24 (58%)
		C2H2 Zn finger	1096..1116	CDD:275368	9/19 (47%)
Spps	NP_001262902.1	COG5048	<725..827	CDD:227381	41/130 (32%)
		C2H2 Zn finger	742..764	CDD:275368	5/21 (24%)
		zf-H2C2_2	756..783	CDD:290200	11/26 (42%)
		C2H2 Zn finger	772..794	CDD:275368	9/21 (43%)
		zf-H2C2_2	786..809	CDD:290200	12/22 (55%)
		zf-C2H2	800..822	CDD:278523	10/21 (48%)
		C2H2 Zn finger	802..822	CDD:275368	9/19 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR23235
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.100