DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sr and bowl

DIOPT Version :9

Sequence 1:	NP_001262693.1	Gene:	sr / 42162	FlyBaseID:	FBgn0003499	Length:	1271	Species:	Drosophila melanogaster
Sequence 2:	NP_001245861.1	Gene:	bowl / 33602	FlyBaseID:	FBgn0004893	Length:	744	Species:	Drosophila melanogaster

Alignment Length:	569	Identity:	120/569 - (21%)
Similarity:	181/569 - (31%)	Gaps:	203/569 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   709 SQQQASKISYRGIFTTTGNA------------MNAAAAAAAAAAQQQHQQQQQHQQQLPSPQLGV 761
            ::..:|:||..|     |.|            ||:.||||||...                  |.
  Fly     3 TESSSSEISGGG-----GGAIPMLRPSRMDQFMNSMAAAAAAVGG------------------GG 44

  Fly   762 LAGPMSPPSNSLGNSWGLPSPDKTMFQPPLFSLPAHYATMQQQQQQQQQQQQQQQQQQAAGAAPS 826
            |.|.......|.|:..|                               .|......:.::.:..|
  Fly    45 LPGAADRNGGSGGSDGG-------------------------------SQNGNGDSRNSSASRIS 78

  Fly   827 PYDDGRAAAAAAAQHAELLGLTMDCTPLLLKQPPPSYAGASAGF----------PGLGDLHSSHE 881
            .|:    ...|..||  |.||.....|     ||||:....:.|          ||
  Fly    79 AYE----TQLAYQQH--LAGLHGPPPP-----PPPSHHREISAFVPVLPTGKVRPG--------- 123

  Fly   882 QQLQQQQYVRSQPKYQWLDSPADYAQQQQQVQQVQQQQQQQQTLVLPGPTSSASSSNAALGVL-- 944
                      |...|:.:...||     ::.:...::......::..||...........|||
  Fly   124 ----------SNSNYEIIAMMAD-----KRKELALREAAAAAAMLGRGPGGPGGPGVPPPGVLYG 173

  Fly   945 ---IPKQENYPDMQPSSNGTGYSGGSGGSSAAAAAAAAAAAAAVQLAEYSPSTSKG-HEILSQVY 1005
               :|.       .|...|.|.|....||......|||||.       :.|....| |..|.:
  Fly   174 PAGVPP-------PPYLTGPGPSPTGAGSFPFPPGAAAAAL-------FPPGLGPGMHAGLDR-- 222

  Fly  1006 QQSTVPLKLVPVKPR----------KYPNRP----------SKTPVHERPYACPVENCDRRFSRS 1050
                   :|:....|          |:.||.          .:|...||||:|.:  |.:.|.|.
  Fly   223 -------RLLRAPGRASRPKKQFICKFCNRQFTKSYNLLIHERTHTDERPYSCDI--CGKAFRRQ 278

  Fly  1051 DELTRHIRIHTGQKPFQCR----------------------------ICMRSFSRSDHLTTHIRT 1087
            |.|..|..||:.:|||:|.                            :|.|||::..:|.||:.|
  Fly   279 DHLRDHRYIHSKEKPFKCTECGKGFCQSRTLAVHKILHMEESPHKCPVCSRSFNQRSNLKTHLLT 343

  Fly  1088 HTGEKPFSCDICGRKFARSDEKKRHAKVHLKQRIKKEKVRGEQQQQQQQQQQQQQQQQQQQLQQQ 1152
            ||..||:.|..||:.|.|:.:.:|||..|....:..    |:       .....::.:.:.|...
  Fly   344 HTDHKPYECSSCGKVFRRNCDLRRHALTHAVGEVNS----GD-------YVDVGEEDEARNLSGD 397

  Fly  1153 QEQHHLSLQQHQQYQQHHLLHSADLAIVTSSASMXRLENSASSVDQAQT 1201
            :|...|.:...:|...|:|..|......:.|..| ||:..| ::|..::
  Fly   398 EEDSLLEVDSPRQSPVHNLGESGGSGEKSESERM-RLKRKA-AIDHEES 444

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sr	NP_001262693.1	zf-C2H2	1036..1060	CDD:278523	8/23 (35%)
		C2H2 Zn finger	1038..1060	CDD:275368	7/21 (33%)
		zf-H2C2_2	1052..1077	CDD:290200	12/52 (23%)
		C2H2 Zn finger	1068..1088	CDD:275368	8/47 (17%)
		zf-H2C2_2	1080..1105	CDD:290200	12/24 (50%)
		C2H2 Zn finger	1096..1116	CDD:275368	8/19 (42%)
bowl	NP_001245861.1	COG5048	<232..372	CDD:227381	41/141 (29%)
		C2H2 Zn finger	240..260	CDD:275368	3/19 (16%)
		zf-H2C2_2	252..277	CDD:290200	8/26 (31%)
		C2H2 Zn finger	268..288	CDD:275368	7/21 (33%)
		zf-H2C2_2	280..303	CDD:290200	8/22 (36%)
		C2H2 Zn finger	296..316	CDD:275368	1/19 (5%)
		zf-C2H2	322..344	CDD:278523	7/21 (33%)
		C2H2 Zn finger	324..344	CDD:275368	7/19 (37%)
		zf-H2C2_2	336..361	CDD:290200	12/24 (50%)
		C2H2 Zn finger	352..372	CDD:275368	8/19 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2698
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.940