DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sr and btd

DIOPT Version :9

Sequence 1:	NP_001262693.1	Gene:	sr / 42162	FlyBaseID:	FBgn0003499	Length:	1271	Species:	Drosophila melanogaster
Sequence 2:	NP_511100.1	Gene:	btd / 31912	FlyBaseID:	FBgn0000233	Length:	644	Species:	Drosophila melanogaster

Alignment Length:	734	Identity:	186/734 - (25%)
Similarity:	264/734 - (35%)	Gaps:	289/734 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly   663 QQQQQQQQQQQQHQQQPLHQQQQLQHQQQQQHHQQHYQQHAIQHQQSQQQASKISYRGIFTTTGN 727
            ||.|.||||..||||....||..| |.||.|||..      :.|||:|||
  Fly    14 QQHQAQQQQHAQHQQHAQQQQHHL-HMQQAQHHLH------LSHQQAQQQ--------------- 56

  Fly   728 AMNAAAAAAAAAAQQQH--QQQQQHQQQLPSPQLGVLAGPMSPPSNSLGNSWGLPSPDKTMFQPP 790
                         ..||  |||||.|||
  Fly    57 -------------HMQHLTQQQQQQQQQ------------------------------------- 71

  Fly   791 LFSLPAHYATMQQQQQQQQQQQQQQQQQQAAGAAPSPYDDGRAAAAAAAQHAELLGLTMDCTPLL 855
                       |||||||||||||.||||        :|...|||..:|
  Fly    72 -----------QQQQQQQQQQQQQPQQQQ--------HDFLSAAALLSA---------------- 101

  Fly   856 LKQPPPSYAGASAG-FPGLGDLHSSHEQQLQ-------------QQQYVRSQPKYQWLDSPADYA 906
                |||.:|:|:| ..|...|:.....:|:             ....::|.|....: ||:.:.
  Fly   102 ----PPSLSGSSSGSSSGSSPLYGKPPMKLELPYPQASSTGTASPNSSIQSAPSSASV-SPSIFP 161

  Fly   907 QQQQQVQQVQQQQQQQQTLVLPGPTSSASSSNAALGVLIPKQENYPDMQPSSNGTGYSGGSGGSS 971
            ...|....:........|.:.| ||::|:.:.|.              .|:|:....|..|..::
  Fly   162 SPAQSFASISASPSTPTTTLAP-PTTAAAGALAG--------------SPTSSSPSSSAASAAAA 211

  Fly   972 AAAAAAAAA--AAAAVQLAEY---------SPSTSK------------------------GHEIL 1001
            |||||||||  .||||..|.|         .|:.|:                        .|:
  Fly   212 AAAAAAAAADLGAAAVASAAYGWNTAYSGLGPARSQFPYAQYASDYYGNAVGMSSSAAWFSHQ-- 274

  Fly  1002 SQVYQQSTVPLKLVPVKPRKYP--------------------------NRPSKTPVHERP----- 1035
            .::||         |...:.||                          |..|..|....|
  Fly   275 ERLYQ---------PWSSQSYPGFNFDDIAFQTQLQRRSVRCTCPNCTNEMSGLPPIVGPDERGR 330

  Fly  1036 --YACPVENCDRRFSRSDELTRHIRIHTGQKPFQCRICMRSFSRSDHLTTHIRTHTGEKPFSCDI 1098
              :.|.:..|:|.:.::..|..|:|.|||::||.|..|.:.|||||.|..|.||||..:|::|.|
  Fly   331 KQHICHIPGCERLYGKASHLKTHLRWHTGERPFLCLTCGKRFSRSDELQRHGRTHTNYRPYACPI 395

  Fly  1099 CGRKFARSDEKKRHAKVHLKQRIKKEKVRGEQQQQQ------QQQQQQQQQQQQQQLQQQQEQ-- 1155
            |.:||:|||...:|.|.|.|.:..|:.:..|.::|.      ::::::..:.....::.:|||
  Fly   396 CSKKFSRSDHLSKHKKTHFKDKKSKKVLAAEAKEQAAAAIKLEKKEKKSGKPLTPPVEFKQEQPD 460

  Fly  1156 --------HHLSLQQHQ-----------------QYQQHHLLHSADLAIV------TSSASMXRL 1189
                    .:.:|.||.                 |.|......||..:.|      :||.::...
  Fly   461 TTPLVNYAPYANLYQHSTSAGSSVNPPPPPPPLFQQQMTTTTSSAAASFVEQPWSSSSSRAIQPA 525

  Fly  1190 ENSASSVDQAQTPTP------------TPAPAAT---QKVSLALALDLDESAFPFELTSDYG-TL 1238
            ..||||...:...:|            :||.:||   |....|||:..:.     :|.::|| |:
  Fly   526 TTSASSSSSSSASSPAAAVVSAIGSASSPAASATALAQHHYAALAMQSES-----QLAAEYGLTM 585

  Fly  1239 SPLTSPRQFNYVWVGQDSS 1257
            |.|.|       ...||||
  Fly   586 SGLAS-------GASQDSS 597

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sr	NP_001262693.1	zf-C2H2	1036..1060	CDD:278523	6/23 (26%)
		C2H2 Zn finger	1038..1060	CDD:275368	6/21 (29%)
		zf-H2C2_2	1052..1077	CDD:290200	11/24 (46%)
		C2H2 Zn finger	1068..1088	CDD:275368	10/19 (53%)
		zf-H2C2_2	1080..1105	CDD:290200	12/24 (50%)
		C2H2 Zn finger	1096..1116	CDD:275368	10/19 (53%)
btd	NP_511100.1	C2H2 Zn finger	338..357	CDD:275368	5/18 (28%)
		zf-H2C2_2	349..374	CDD:290200	11/24 (46%)
		C2H2 Zn finger	365..385	CDD:275368	10/19 (53%)
		zf-H2C2_2	377..402	CDD:290200	12/24 (50%)
		zf-C2H2	391..413	CDD:278523	10/21 (48%)
		C2H2 Zn finger	393..413	CDD:275368	10/19 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR23235
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.010