DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sr and hsr1

DIOPT Version :9

Sequence 1:	NP_001262693.1	Gene:	sr / 42162	FlyBaseID:	FBgn0003499	Length:	1271	Species:	Drosophila melanogaster
Sequence 2:	NP_593553.1	Gene:	hsr1 / 2543251	PomBaseID:	SPAC3H1.11	Length:	582	Species:	Schizosaccharomyces pombe

Alignment Length:	687	Identity:	136/687 - (19%)
Similarity:	208/687 - (30%)	Gaps:	303/687 - (44%)

- Green bases have known domain annotations that are detailed below.

  Fly   503 PQVISVASPVLSHCSPLKEERSTPPALAIVKEESSNNSCNMY--PQHNNNNNN--------NNNT 557
            |||         :.||....:|:.|.        .:|||..|  |.|.:.:|:        :|..
pombe    19 PQV---------NTSPFAPAQSSSPL--------PSNSCREYSLPSHPSTHNSSVAYVDSQDNKP 66

  Fly   558 TSSST------TTTSKQTTSESNTECVGSP-----GNHTQ------SHQQQQQQLQHNNTSSSNS 605
            ...||      .:.|..:....||..:..|     |..:|      |..|...|: :|:.|:.||
pombe    67 PLVSTLHFSLAPSLSPSSAQSHNTALITEPLTSFIGGTSQYPSASFSTSQHPSQV-YNDGSTLNS 130

  Fly   606 NCHHSHQQQQQQQQQQHMSSPQQQYQQHQILHQQQQLPNHHHHHHHHHHHHSQLQQLQQQQQQQQ 670
            |                              :..|||.|::..
pombe   131 N------------------------------NTTQQLNNNNGF---------------------- 143

  Fly   671 QQQQHQQQPLHQQQQLQHQQQQQHHQ--QHYQ-----------QHAIQH-----QQSQQQASKIS 717
                   ||..|...:...:..|:||  |.|.           :...||     |.|..:||
pombe   144 -------QPPPQNPGISKSRIAQYHQPSQTYDDTVDSSFYDWYKAGAQHNLAPPQSSHTEAS--- 198

  Fly   718 YRGIFTTTGNAMNA-----------AAAAAAAAAQQ-------QHQQQQQHQQQL--PSPQLGVL 762
             :|...:|..|.:|           ..|:.|...|:       :::...|:|..|  ..|.:...
pombe   199 -QGYMYSTNTAHDATDIPSSFNFYNTQASTAPNPQEINYQWSHEYRPHTQYQNNLLRAQPNVNCE 262

  Fly   763 AGPMSPPSNSLGNSWGLPSPDKTMFQPPLF---SLPAHYATMQQQQQQQQQQQQQQQQQQAAGAA 824
            ..|.:.|:..              ||.|.:   :|...|.|:..|                  ..
pombe   263 NFPTTVPNYP--------------FQQPSYNPNALVPSYTTLVSQ------------------LP 295

  Fly   825 PSP---YDDGRAAAAAAAQHAELLGLTMDCTPLLLKQPPPSYAGASAGFPGLGDLHSSHEQQLQQ 886
            |||   ...|..:.|::        :..:|:...:|...|||             |:  ||::..
pombe   296 PSPCLTVSSGPLSTASS--------IPSNCSCPSVKSSGPSY-------------HA--EQEVNV 337

  Fly   887 QQYVRSQPKYQWLDSPADYAQQQQQVQQVQQQQQQQQTLVLPGPTSSASSSNAALGVLIPKQENY 951
            ..|....|...:.|:|      ||.|                  |.|.:|...
pombe   338 NSYNGGIPSTSYNDTP------QQSV------------------TGSYNSGET------------ 366

  Fly   952 PDMQPSSNGTGYSGGSGGSSAAAAAAAAAAAAAVQLAEYSPSTSKGHEILSQVYQQSTVPLKLVP 1016
              |....|.|..||                        .||::.:..|.:..:....::..:
pombe   367 --MSTYLNQTNTSG------------------------RSPNSMEATEQIGTIGTDGSMKRR--- 402

  Fly  1017 VKPRKYPNRPSKTPVHERPYACPVENCDRRFSRSDELTRHIRIHTGQKPFQCRICMRSFSRSDHL 1081
             |.|:..||  ||.|...|                          |.|.|.|..|.:.|.||:||
pombe   403 -KRRQPSNR--KTSVPRSP--------------------------GGKSFVCPECSKKFKRSEHL 438

  Fly  1082 TTHIRT-HTGEKPFSCDICGRKFARSDEKKRHAKVHL 1117
            ..|||: ||.||||.| |||::|:|.|..::|.::|:
pombe   439 RRHIRSLHTSEKPFVC-ICGKRFSRRDNLRQHERLHV 474

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sr	NP_001262693.1	zf-C2H2	1036..1060	CDD:278523	0/23 (0%)
		C2H2 Zn finger	1038..1060	CDD:275368	0/21 (0%)
		zf-H2C2_2	1052..1077	CDD:290200	6/24 (25%)
		C2H2 Zn finger	1068..1088	CDD:275368	10/20 (50%)
		zf-H2C2_2	1080..1105	CDD:290200	16/25 (64%)
		C2H2 Zn finger	1096..1116	CDD:275368	8/19 (42%)
hsr1	NP_593553.1	COG5048	103..582	CDD:227381	114/586 (19%)
		zf-C2H2	423..444	CDD:278523	10/20 (50%)
		C2H2 Zn finger	425..446	CDD:275368	10/20 (50%)
		zf-H2C2_2	437..462	CDD:290200	16/25 (64%)
		C2H2 Zn finger	454..473	CDD:275368	8/19 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2698
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.030