DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sr and prz1

DIOPT Version :9

Sequence 1:	NP_001262693.1	Gene:	sr / 42162	FlyBaseID:	FBgn0003499	Length:	1271	Species:	Drosophila melanogaster
Sequence 2:	NP_593073.1	Gene:	prz1 / 2541806	PomBaseID:	SPAC4G8.13c	Length:	681	Species:	Schizosaccharomyces pombe

Alignment Length:	747	Identity:	140/747 - (18%)
Similarity:	255/747 - (34%)	Gaps:	157/747 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   452 EAHKQLIEALPGDLNTPVTT-----SSDIPSFFGPTTVVEPPPITGSIESEDLSLEPQVISVASP 511
            ||:::..:..|..|...::.     ||::.::...|::.:.|....::.||          |:|.
pombe     8 EANRRFKDLNPSSLYDNLSKPDLGGSSELHTYMNDTSLADIPLFEDTLASE----------VSSS 62

  Fly   512 VLSHCSPLKEERSTPPALAIVKEESSNNSCNMYPQHNN----NNNNNNNTTSSSTTTTSKQTTSE 572
            ::|:.|....:...|......|..|.::..:.||:..|    :....|:|   |.:....|...|
pombe    63 LISNPSKNNIQHLHPNTSEPFKTSSKSDEYDSYPRTGNVPTFSFTELNDT---SVSGFGSQAVFE 124

  Fly   573 SNTECVGSPGNHTQSHQQQQQQLQHNNTSSSNSNCHHSHQQQQQQQQQQHMSSPQQQYQQHQILH 637
            ::...:.:|.|..|:....|..   ::|.::|....::...::|...:.::..|.......|.|.
pombe   125 NSVSPLSNPSNSPQAFDLTQGS---SSTHNANDFTVNNVGSRRQSIYEFNIGIPSSNIDSSQFLP 186

  Fly   638 QQQQLPNHHHHHHHHHHHHSQLQQLQQQQQQQQQQQQHQQQPLHQQQQLQHQQQQQHHQQHYQQH 702
            ..:.:                                       ...::......|.........
pombe   187 VSRAI---------------------------------------AASEISPSSSPQLLTSFLPSG 212

  Fly   703 AIQHQQSQQQASKISYRGIFTTTGNAMNAAAAAAAAAAQQQHQQQQQHQQQLPS-----PQL--- 759
            ::.:..|......:          .|:..|.|........|....:...::.||     |.|
pombe   213 SVSNPSSPYLQGSV----------GALYEADAFNFVDVMSQASGTEVDSERFPSVDFEDPSLLME 267

  Fly   760 --------GVLAGPMSPPSN-SLG---------NSWGLP-SPDKTMFQPPL-----FSLP----- 795
                    |..|..:.|||: |||         ::.|:. ..|.|...|.:     .|.|
pombe   268 NQQNITGTGSFADYLQPPSSGSLGAFTNASPGESNTGIDFDTDNTNLNPSVDLLSNHSTPSFIFE 332

  Fly   796 -------AHYATMQQQQQQQQQQQQQQQQQQAAGAAPSPYDDGRAAAAAAAQHAELLGLTMDCTP 853
                   :|.::........:....:..::....:..||:.:..|.|:......:.:      :|
pombe   333 NSPSAEFSHQSSPYLVPNSGRTLNSENARESTIRSVNSPFSEDHADASLTTHVFDPI------SP 391

  Fly   854 LLLKQPPPSY-AGASAGFPGLGDLHSSHEQQLQQQQYVRSQPKYQWLDSPADYAQQQQQV--QQV 915
            ..|.....:| :...:|.|.:..:.||..:. |....:.:.|..| .|....|:|....|  |..
pombe   392 TALSNSVLNYDSNNFSGTPQINVVPSSPSKS-QSGPSLPANPLLQ-TDISITYSQSASPVSGQPA 454

  Fly   916 QQQQQ---QQQTLVLP--GPTSSASSSNAALGVLIPKQENYPDMQPSSNGTGYSGGSGGSSAAAA 975
            ..:..   |...|..|  .||.:|...:.:.|......|..|.:        |:..|..|...:.
pombe   455 MNENSYDLQNANLCAPEMSPTYTARHRSNSAGSRFDAYEPIPQL--------YTHFSHSSECLSV 511

  Fly   976 AAAAAAAAAVQLAEYSPSTSKGHEILSQVYQQSTVPL-----KLVPVKPRKYPNRPSKTPVHER- 1034
            ......     |.:.....||.::.||   .::|.|.     .||..|.....:..:|:....:
pombe   512 NQDTEL-----LGKIENDNSKSNDYLS---VRNTRPRSRSLNSLVGNKSENSSSSKAKSESKSQG 568

  Fly  1035 PYACPVENCDRRFSRSDELTRHIRIHTGQKPFQCRICMRSFSRSDHLTTHIRTHTGEKPFSCDIC 1099
            .|.|....|::||:|:..|..|:..||..:||||.||.:||:|......|.:.|||.|.|:|..|
pombe   569 NYVCTFAGCNKRFTRAYNLKSHMNTHTNYRPFQCSICKKSFARQHDKRRHEQLHTGIKAFACVTC 633

  Fly  1100 GRKFARSDEKKRHAKVHLKQR-IKKEKVRGEQ 1130
            .::|||.|...||.|..:.|. ::....||.|
pombe   634 NQRFARMDALNRHYKSEVGQNCLRTATERGIQ 665

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sr	NP_001262693.1	zf-C2H2	1036..1060	CDD:278523	8/23 (35%)
		C2H2 Zn finger	1038..1060	CDD:275368	7/21 (33%)
		zf-H2C2_2	1052..1077	CDD:290200	12/24 (50%)
		C2H2 Zn finger	1068..1088	CDD:275368	7/19 (37%)
		zf-H2C2_2	1080..1105	CDD:290200	9/24 (38%)
		C2H2 Zn finger	1096..1116	CDD:275368	9/19 (47%)
prz1	NP_593073.1	COG5048	121..620	CDD:227381	98/574 (17%)
		zf-C2H2	570..594	CDD:278523	8/23 (35%)
		C2H2 Zn finger	577..594	CDD:275368	6/16 (38%)
		zf-H2C2_2	586..611	CDD:290200	12/24 (50%)
		C2H2 Zn finger	602..622	CDD:275368	7/19 (37%)
		zf-H2C2_2	616..639	CDD:290200	9/22 (41%)
		C2H2 Zn finger	630..648	CDD:275368	8/17 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2698
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.030