DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sr and Egr4

DIOPT Version :9

Sequence 1:	NP_001262693.1	Gene:	sr / 42162	FlyBaseID:	FBgn0003499	Length:	1271	Species:	Drosophila melanogaster
Sequence 2:	NP_062010.1	Gene:	Egr4 / 25129	RGDID:	2546	Length:	478	Species:	Rattus norvegicus

Alignment Length:	428	Identity:	136/428 - (31%)
Similarity:	179/428 - (41%)	Gaps:	129/428 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   755 PSPQLGVLAGPMSPPSNSLGNSWGLPS-PDKTMFQPPLFSLPAHYATMQQQQQQQQQQQQQQQQQ 818
            |||:......|:..|         .|: ||..:  |.|:|                       ..
  Rat   113 PSPEAAASRSPLDVP---------FPAGPDALL--PDLYS-----------------------PD 143

  Fly   819 QAAGAAPSPYDDGRAAAAAAAQ----------------HAELLGLTMDCTPLLLKQPPPSYAGAS 867
            .::.|.|..:.:...:|.|.:|                .|......:|......|.|...:...|
  Rat   144 LSSAAFPEAFWEAAPSAGAPSQCLFEPQLSPPDVKPGLRAPPASPALDAAASAFKGPYAPWELLS 208

  Fly   868 AGFPGLGDLHSSHEQQLQQQQYVRSQPKYQWLDS---PADYAQQQQQVQQVQQQQQQQQTLVLPG 929
            ||.||......|. |...:.::.....|.:.|.|   ||:                      |||
  Rat   209 AGAPGNCGSQGSF-QTTPEARFSAVGTKVEDLLSISCPAE----------------------LPG 250

  Fly   930 PTS------SASSSNAALGVLIPKQENYPDMQPSSNGTGYSGGSGGSSAA-------------AA 975
            |.|      :..:.:.|.|.|....|..|.:.....|.|.|||.||...|             ||
  Rat   251 PASRLYPPGAYDAFSLAPGDLGEGTEGLPALLTPPGGEGGSGGEGGEFLAVPQAQLSPLGLRGAA 315

  Fly   976 AAAAAAAAAVQL-------AEYSPSTSKGHEILSQVYQQSTVPLKLVPVKPRKYPNRPSKTPV-- 1031
            .|..:.|....|       |..||:||                  ....|.|:...|..|...
  Rat   316 TADFSKALVADLPGGSGVAAPSSPATS------------------FPAAKARRKGRRGGKCSARC 362

  Fly  1032 -----HERPYACPVENCDRRFSRSDELTRHIRIHTGQKPFQCRICMRSFSRSDHLTTHIRTHTGE 1091
                 |.:.:|||||:|.|.|:|||||.||:|||||.||||||||:|:||||||||||:||||||
  Rat   363 FCPRPHVKAFACPVESCVRTFARSDELNRHLRIHTGHKPFQCRICLRNFSRSDHLTTHVRTHTGE 427

  Fly  1092 KPFSCDICGRKFARSDEKKRHAKVHLKQRIK-KEKVRG 1128
            |||:||:|||:||||||||||:||||||:.: :|:::|
  Rat   428 KPFACDVCGRRFARSDEKKRHSKVHLKQKARAEERLKG 465

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sr	NP_001262693.1	zf-C2H2	1036..1060	CDD:278523	16/23 (70%)
		C2H2 Zn finger	1038..1060	CDD:275368	15/21 (71%)
		zf-H2C2_2	1052..1077	CDD:290200	19/24 (79%)
		C2H2 Zn finger	1068..1088	CDD:275368	16/19 (84%)
		zf-H2C2_2	1080..1105	CDD:290200	20/24 (83%)
		C2H2 Zn finger	1096..1116	CDD:275368	16/19 (84%)
Egr4	NP_062010.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	15..37
		zf-C2H2	372..396	CDD:278523	16/23 (70%)
		C2H2 Zn finger	374..396	CDD:275368	15/21 (71%)
		zf-H2C2_2	388..413	CDD:290200	19/24 (79%)
		COG5048	400..>458	CDD:227381	49/57 (86%)
		C2H2 Zn finger	404..424	CDD:275368	16/19 (84%)
		zf-H2C2_2	416..441	CDD:290200	20/24 (83%)
		C2H2 Zn finger	432..452	CDD:275368	16/19 (84%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	50	1.000	Domainoid score	I11371
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR23235
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.100