Protein Alignment sr and Wt1

DIOPT Version :9

• Sequence 1: NP_001262693.1
• Gene: sr / 42162
• FlyBaseID: FBgn0003499
• Length: 1271
• Species: Drosophila melanogaster
• Sequence 2: NP_113722.2
• Gene: Wt1 / 24883
• RGDID: 3974
• Length: 448
• Species: Rattus norvegicus
• Alignment Length: 444
• Identity: 128/444 - (28%)
• Similarity: 173/444 - (38%)
• Gaps: 129/444 - (29%)

  Fly   767 SPPSNSLGNSWGLPSPDKTMFQPPLFSLPAHYATMQQQQQQQQQQQQQQQQQQA----------- 820
            :||..|...|.|.|:|......||    |..::.::|:......:..::|...|
  Rat    41 APPGASAYGSLGGPAPPPAPPPPP----PPPHSFIKQEPSWGGAEPHEEQCLSAFTLHFSGQFTG 101

  Fly   821 -AGA------APSPYDDGRAAAAAAAQHAELLGLTMDCTPLLLKQ--------PPPSYAGA---- 866
             |||      .|.|.....:..|....:|..|...::..|.:..|        ..|||...
  Rat   102 TAGACRYGPFGPPPPSQASSGQARMFPNAPYLPSCLESQPSIRNQGYSTVTFDGAPSYGHTPSHH 166

  Fly   867 SAGFPGLGDLHS-SHE----QQ--LQQQQYVRSQPKYQWLDSPAD-------------YAQQQ-- 909
            :|.||.    || .||    ||  |.:|||....|.| ...:|.|             |:...
  Rat   167 AAQFPN----HSFKHEDPMGQQGSLGEQQYSVPPPVY-GCHTPTDSCTGSQALLLRTPYSSDNLY 226

  Fly   910 QQVQQVQQQQQQQQTL--VLPGPTSSASSSNAALGVLIPKQENYPDMQPSSNGTGYSGG------ 966
            |...|::.....|..|  .|.|..:.:|||           ..:.:.| |::||||...
  Rat   227 QMTSQLECMTWNQMNLGATLKGMAAGSSSS-----------VKWTEGQ-SNHGTGYESENHTTPI 279

  Fly   967 -----------------------SGGSSAAAAAAAAAAAAAVQLAEYSPSTSKGHEILSQVYQQS 1008
                                   ||.:.....:|:..:.....:..| |..:|.:..||.:...|
  Rat   280 LCGAQYRIHTHGVFRGIQDVRRVSGVAPTLVRSASETSEKRPFMCAY-PGCNKRYFKLSHLQMHS 343

  Fly  1009 TVPLKLVPVKPRKYPNRPSKTPVHERPYACPVENCDRRFSRSDELTRHIRIHTGQKPFQCRICMR 1073
                       ||:..        |:||.|..::|:|||||||:|.||.|.|||.|||||:.|.|
  Rat   344 -----------RKHTG--------EKPYQCDFKDCERRFSRSDQLKRHQRRHTGVKPFQCKTCQR 389

  Fly  1074 SFSRSDHLTTHIRTHTG---EKPFSC--DICGRKFARSDEKKRHAKVHLKQRIK 1122
            .|||||||.||.|||||   ||||||  ..|.:|||||||..||..:|.:...|
  Rat   390 KFSRSDHLKTHTRTHTGKTSEKPFSCRWHSCQKKFARSDELVRHHNMHQRNMTK 443

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sr	NP_001262693.1	zf-C2H2	1036..1060	CDD:278523	14/23 (61%)
		C2H2 Zn finger	1038..1060	CDD:275368	13/21 (62%)
		zf-H2C2_2	1052..1077	CDD:290200	15/24 (63%)
		C2H2 Zn finger	1068..1088	CDD:275368	13/19 (68%)
		zf-H2C2_2	1080..1105	CDD:290200	18/29 (62%)
		C2H2 Zn finger	1096..1116	CDD:275368	11/21 (52%)
Wt1	NP_113722.2	WT1	1..320	CDD:280348	62/299 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	48..83		8/38 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	166..186		9/23 (39%)
		9aaTAD. /evidence=ECO:0000250|UniProtKB:P19544	235..243		1/7 (14%)
		COG5048	312..>440	CDD:227381	66/147 (45%)
		C2H2 Zn finger	327..346	CDD:275368	6/29 (21%)
		zf-H2C2_2	338..365	CDD:290200	11/45 (24%)
		C2H2 Zn finger	354..376	CDD:275368	13/21 (62%)
		Important for interaction with target DNA. /evidence=ECO:0000250	366..380		9/13 (69%)
		zf-H2C2_2	369..393	CDD:290200	15/23 (65%)
		C2H2 Zn finger	384..404	CDD:275368	13/19 (68%)
		Important for interaction with target DNA. /evidence=ECO:0000250	392..400		6/7 (86%)
		KTS motif. /evidence=ECO:0000250	407..409		0/1 (0%)
		C2H2 Zn finger	415..437	CDD:275368	11/21 (52%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000