DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sr and Egr1

DIOPT Version :9

Sequence 1:	NP_001262693.1	Gene:	sr / 42162	FlyBaseID:	FBgn0003499	Length:	1271	Species:	Drosophila melanogaster
Sequence 2:	NP_036683.1	Gene:	Egr1 / 24330	RGDID:	2544	Length:	508	Species:	Rattus norvegicus

Alignment Length:	576	Identity:	166/576 - (28%)
Similarity:	226/576 - (39%)	Gaps:	222/576 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   723 TTTGNAMNAAAAAAAAAAQQQHQQQQQHQQQLPSPQLGVLA---------------GPMSPPSNS 772
            :::|......:.:.::|...|.:..:|..:.|.:.....:|               ....||...
  Rat    41 SSSGGGGGGGSNSGSSAFNPQGEPSEQPYEHLTTESFSDIALNNEKALVETSYPSQTTRLPPITY 105

  Fly   773 LGNSWGLPSPD--KTMFQPPLFSLPAHYATMQQQQQQQQQQQQQQQQQQAAGAAPSPYDDGRAAA 835
            .|.....|:|:  .|::..|||||.:...:|             .....::.:||||    .|::
  Rat   106 TGRFSLEPAPNSGNTLWPEPLFSLVSGLVSM-------------TNPPTSSSSAPSP----AASS 153

  Fly   836 AAAAQHAELLGLTM---DCTPL-----------------------------LLKQPPPSYAGASA 868
            :::|..:..|...:   |.:|:                             .|:.|||:|.....
  Rat   154 SSSASQSPPLSCAVPSNDSSPIYSAAPTFPTPNTDIFPEPQSQAFPGSAGTALQYPPPAYPATKG 218

  Fly   869 GFPGLGDLHSSHEQQLQQQQYVRSQPKYQWLDSPADYA---QQQQQVQQVQQQQQQQQTLVLPGP 930
            ||                  .|...|.|.:.....|.:   ..|:..|.::.:.||
  Rat   219 GF------------------QVPMIPDYLFPQQQGDLSLGTPDQKPFQGLENRTQQ--------- 256

  Fly   931 TSSASSSNAALGVLIPKQENYPDMQPSSNGTGYSGGSGGSSAAAAAAAAAAAAAVQLAEYSPSTS 995
                                 |.:.|.|....::..||.....|
  Rat   257 ---------------------PSLTPLSTIKAFATQSGSQDLKA--------------------- 279

  Fly   996 KGHEILSQVYQQSTVPLKLVPVKPRKYPNRPSKTPVHERPYACPVENCDRRFSRSDELTRHIRIH 1060
                 |:..||...:.    |.:.|||||||||||.||||||||||:||||||||||||||||||
  Rat   280 -----LNNTYQSQLIK----PSRMRKYPNRPSKTPPHERPYACPVESCDRRFSRSDELTRHIRIH 335

  Fly  1061 TGQKPFQCRICMRSFSRSDHLTTHIRTHTGEKPFSCDICGRKFARSDEKKRHAKVHLKQRIKKEK 1125
            |||||||||||||:||||||||||||||||||||:|||||||||||||:|||.|:||:|:.||
  Rat   336 TGQKPFQCRICMRNFSRSDHLTTHIRTHTGEKPFACDICGRKFARSDERKRHTKIHLRQKDKK-- 398

  Fly  1126 VRGEQQQQQQQQQQQQQQQQQQQLQQQQEQHHLSLQQHQQYQQHHLLHSADLAIVTSSASMXRLE 1190
                                                             ||.::|.|||
  Rat   399 -------------------------------------------------ADKSVVASSA------ 408

  Fly  1191 NSASSVDQAQTPTPT--PAPAATQKVSLALALDLDESAFPFELTSDYGTLSPLTSP 1244
              |||:....:|..|  |:||.|              :||..:.:.|.:....|.|
  Rat   409 --ASSLSSYPSPVATSYPSPATT--------------SFPSPVPTSYSSPGSSTYP 448

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sr	NP_001262693.1	zf-C2H2	1036..1060	CDD:278523	22/23 (96%)
		C2H2 Zn finger	1038..1060	CDD:275368	20/21 (95%)
		zf-H2C2_2	1052..1077	CDD:290200	23/24 (96%)
		C2H2 Zn finger	1068..1088	CDD:275368	18/19 (95%)
		zf-H2C2_2	1080..1105	CDD:290200	23/24 (96%)
		C2H2 Zn finger	1096..1116	CDD:275368	17/19 (89%)
Egr1	NP_036683.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	18..78		5/36 (14%)
		DUF3446	107..182	CDD:288757	19/91 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	136..210		11/90 (12%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	292..311		14/18 (78%)
		zf-C2H2	311..335	CDD:278523	22/23 (96%)
		C2H2 Zn finger	313..335	CDD:275368	20/21 (95%)
		zf-H2C2_2	327..352	CDD:290200	23/24 (96%)
		COG5048	338..>396	CDD:227381	51/57 (89%)
		C2H2 Zn finger	343..363	CDD:275368	18/19 (95%)
		zf-H2C2_2	355..380	CDD:290200	23/24 (96%)
		C2H2 Zn finger	371..391	CDD:275368	17/19 (89%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	382..453		31/140 (22%)
		7 X 8 AA tandem repeats of [TS](2)-[FY]-[PS]-S-P-[GSAV]-X	413..468		11/50 (22%)
		DUF3432	420..495	CDD:288743	10/43 (23%)
		BES1_N	<424..453	CDD:283367	9/39 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	57	1.000	Domainoid score	I10678
eggNOG	1	0.900	-	-		E33208_3BH2K
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000710
OrthoInspector	1	1.000	-	-		otm45147
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23235
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	7	6.960