Protein Alignment sr and Zic3

DIOPT Version :10

• Sequence 1: NP_001262693.1
• Gene: sr / 42162
• FlyBaseID: FBgn0003499
• Length: 1271
• Species: Drosophila melanogaster
• Sequence 2: NP_033601.2
• Gene: Zic3 / 22773
• MGIID: 106676
• Length: 466
• Species: Mus musculus
• Alignment Length: 546
• Identity: 119/546 - (21%)
• Similarity: 177/546 - (32%)
• Gaps: 197/546 - (36%)

  Fly   726 GNAMNAAAAAAAAAAQQQHQQQQQHQQQLPSPQLGVLAGPMSPPSNSLGNSWGLPSPDKTMFQPP 790
            |::.:||||||||||.:                       :||     ..:..|.|...:.|.|.
Mouse    41 GDSTHAAAAAAAAAAFK-----------------------LSP-----ATAHDLSSGQSSAFTPQ 77

  Fly   791 LFSLPAHYATMQQQQQQQQQQQQQQQQQQAAGAAPSPYDDGR------------AAAAAAAQHAE 843
                .:.||................|.....|||.:.::..|            .||:...||..
Mouse    78 ----GSGYANALGHHHHHHHHHHASQVPTYGGAASAAFNSTRDFLFRQRGSGLSEAASGGGQHGL 138

  Fly   844 LLGLTMDCTPLLLKQP-----PPSYAGASAGFPGLGDLHSSHEQQLQQQQYVRSQPKYQWLDSPA 903
            ..|....     |..|     ||||    ..||||.:..:.|
Mouse   139 FAGSASS-----LHAPAGIPEPPSY----LLFPGLHEQGAGH----------------------- 171

  Fly   904 DYAQQQQQVQQVQQQQQQQQTLVLPGPTSSASSSNAALGV---LIPKQENY-PDMQPSSNGTGYS 964
                                    |.||....::...||:   |..:.:.| |...|.::
Mouse   172 ------------------------PSPTGHVDNNQVHLGLRGELFGRADPYRPVASPRTD----- 207

  Fly   965 GGSGGSSAAAAAAAAAAAAAVQLAEYSPSTSK------GHEILSQVYQQSTVPLK---------- 1013
                           ..||:.|...|||....      .|......::....|:|
Mouse   208 ---------------PYAASAQFPNYSPMNMNMGVNVAAHHGPGAFFRYMRQPIKQELSCKWIEE 257

  Fly  1014 LVPVKPRKYPNRPSKTPVHE---------------RPYACPVENCDRR---FSRSDELTRHIRIH 1060
            ....:|:|..:|...| :||               ..:.|..|.|.|.   |....:|..|||:|
Mouse   258 AQLSRPKKSCDRTFST-MHELVTHVTMEHVGGPEQNNHVCYWEECPREGKSFKAKYKLVNHIRVH 321

  Fly  1061 TGQKPFQCRI--CMRSFSRSDHLTTHIRTHTGEKPFSCDI--CGRKFARSDEKKRHAKVHLKQRI 1121
            ||:|||.|..  |.:.|:||::|..|.|||||||||.|:.  |.|:||.|.::|:|..||...:.
Mouse   322 TGEKPFPCPFPGCGKIFARSENLKIHKRTHTGEKPFKCEFEGCDRRFANSSDRKKHMHVHTSDKP 386

  Fly  1122 KKEKVRGEQQQQQQQQQQQQQQQQQQQLQQQQEQHHLSLQQHQQYQQHHLLHSADLAIVTSSASM 1186
            ...||                       ..:...|..||::|.:      :|.:..:..:.:||.
Mouse   387 YICKV-----------------------CDKSYTHPSSLRKHMK------VHESQGSDSSPAASS 422

  Fly  1187 XRLENSASSVDQAQTPTPTPAPAATQ 1212
             ...::..::..|.:...|..|:|.|
Mouse   423 GYESSTPPAIASANSKDTTKTPSAVQ 448

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sr	NP_001262693.1	zf-C2H2	1036..1060	CDD:395048	9/26 (35%)
		C2H2 Zn finger	1038..1060	CDD:275368	9/24 (38%)
		zf-H2C2_2	1052..1077	CDD:463886	13/26 (50%)
		C2H2 Zn finger	1068..1088	CDD:275368	8/21 (38%)
		zf-H2C2_2	1080..1105	CDD:463886	15/26 (58%)
		C2H2 Zn finger	1096..1116	CDD:275368	8/21 (38%)
Zic3	NP_033601.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	65..103		7/41 (17%)
		zf_ZIC	244..289	CDD:436441	8/45 (18%)
		Nuclear localization signal. /evidence=ECO:0000250	296..321		9/24 (38%)
		C2H2 Zn finger	301..321	CDD:275368	7/19 (37%)
		SFP1	<323..407	CDD:227516	36/106 (34%)
		C2H2 Zn finger	329..351	CDD:275368	8/21 (38%)
		Nuclear localization signal. /evidence=ECO:0000250	329..351		8/21 (38%)
		C2H2 Zn finger	359..381	CDD:275368	8/21 (38%)
		C2H2 Zn finger	389..409	CDD:275368	6/48 (13%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	403..466		9/52 (17%)