Protein Alignment sr and EGR4

DIOPT Version :10

• Sequence 1: NP_001262693.1
• Gene: sr / 42162
• FlyBaseID: FBgn0003499
• Length: 1271
• Species: Drosophila melanogaster
• Sequence 2: NP_001956.4
• Gene: EGR4 / 1961
• HGNCID: 3241
• Length: 486
• Species: Homo sapiens
• Alignment Length: 453
• Identity: 139/453 - (30%)
• Similarity: 184/453 - (40%)
• Gaps: 133/453 - (29%)

  Fly   770 SNSLGNSWGLPSPDKTMFQPPLFSLPAHYATMQQQQQQQQQQQQQQQQQQAAGAAPSPYDDGRAA 834
            |..|.:|..|..|..|  .||..|....:......:.....:..........|.||.|   |..|
Human    60 SGDLADSCFLEGPAPT--PPPGLSYSGSFFIQAVPEHPHDPEALFNLMSGILGLAPFP---GPEA 119

  Fly   835 AAAAAQHAELLGLTMDCTPLLLKQPPPSYAGASAGFPGLGDLHSS-------------------- 879
            ||:.             :||    ..|..||:.|..||..||:|.
Human   120 AASR-------------SPL----DAPFPAGSDALLPGPPDLYSPDLGAAPFPEAFWEASPCAGA 167

  Fly   880 -----HEQQLQQQQY---VRSQPKYQWLD------------------------SPADY-AQQQQQ 911
                 :|.||.....   :|:.|....||                        |..|| |..:.:
Human   168 PSQCLYEPQLSPPDVKPGLRAPPASPALDAVSAFKGPYAPWELLSVGAPGNCGSQGDYQAAPEAR 232

  Fly   912 VQQVQQQQQQQQTLVLPG-----------PTSSASSSNAALGVLIPKQENYPDMQPSSNGTGYSG 965
            ...:..:.:...::..|.           |:.:..:...|.|.|....|..|.:....:|.|.|.
Human   233 FPVIGTKIEDLLSISCPAELPAVPANRLYPSGAYDAFPLAPGDLGEGAEGLPGLLTPPSGEGGSS 297

  Fly   966 GSGGSSAAAA---------AAAAAAAAAVQLAEYSPSTSKGHEILSQVYQQSTVPLKLVPVKPRK 1021
            |.||...|:.         .:||||.....|....|.:|.        .....||    |..|..
Human   298 GDGGEFLASTQPQLSPLGLRSAAAADFPKPLVADIPGSSG--------VAAPPVP----PPPPTP 350

  Fly  1022 YPN--------------------RPSKTPVHERPYACPVENCDRRFSRSDELTRHIRIHTGQKPF 1066
            :|.                    ||     |.:.:|||||:|.|.|:|||||.||:|||||.|||
Human   351 FPQAKARRKGRRGGKCSTRCFCPRP-----HAKAFACPVESCVRSFARSDELNRHLRIHTGHKPF 410

  Fly  1067 QCRICMRSFSRSDHLTTHIRTHTGEKPFSCDICGRKFARSDEKKRHAKVHLKQRIK-KEKVRG 1128
            |||||:|:||||||||||:|||||||||:||:|||:||||||||||:||||||:.: :|:::|
Human   411 QCRICLRNFSRSDHLTTHVRTHTGEKPFACDVCGRRFARSDEKKRHSKVHLKQKARAEERLKG 473

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sr	NP_001262693.1	zf-C2H2	1036..1060	CDD:395048	16/23 (70%)
		C2H2 Zn finger	1038..1060	CDD:275368	15/21 (71%)
		zf-H2C2_2	1052..1077	CDD:463886	19/24 (79%)
		C2H2 Zn finger	1068..1088	CDD:275368	16/19 (84%)
		zf-H2C2_2	1080..1105	CDD:463886	20/24 (83%)
		C2H2 Zn finger	1096..1116	CDD:275368	16/19 (84%)
EGR4	NP_001956.4	PHA03247	<74..339	CDD:223021	55/294 (19%)
		zf-C2H2	380..404	CDD:395048	16/23 (70%)
		C2H2 Zn finger	382..404	CDD:275368	15/21 (71%)
		COG5048	408..>466	CDD:227381	49/57 (86%)
		C2H2 Zn finger	412..432	CDD:275368	16/19 (84%)
		C2H2 Zn finger	440..460	CDD:275368	16/19 (84%)