DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sr and EGR2

DIOPT Version :9

Sequence 1:	NP_001262693.1	Gene:	sr / 42162	FlyBaseID:	FBgn0003499	Length:	1271	Species:	Drosophila melanogaster
Sequence 2:	XP_011537729.1	Gene:	EGR2 / 1959	HGNCID:	3239	Length:	489	Species:	Homo sapiens

Alignment Length:	378	Identity:	163/378 - (43%)
Similarity:	194/378 - (51%)	Gaps:	83/378 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   760 GVLAGPMSPPSNSLGNSWGLPSPDKTMFQPPLFSLPAHYATMQQQQQQ-QQQQQQQQQQQQAAGA 823
            |:|.|..||.|.:..:|....||:      ||.:.|....||.|.|.. .............:|.
Human   132 GILQGVTSPASTTASSSVTSASPN------PLATGPLGVCTMSQTQPDLDHLYSPPPPPPPYSGC 190

  Fly   824 APSPYDDGRAAAAAAAQHAELLGLTMDCTPLLLKQPPPSYAGASAG-----FPGLGDLHSSHEQQ 883
            |...|.|..|..:||         |...:..|...|||||......     ||.:.|.......|
Human   191 AGDLYQDPSAFLSAA---------TTSTSSSLAYPPPPSYPSPKPATDPGLFPMIPDYPGFFPSQ 246

  Fly   884 LQQQQYVRSQPKYQWLDSPADYAQQQQQVQQVQQQQQQQQTLVLPGPTSSASS-SNAALGVLIPK 947
            .|:..:..:.|..:....|.|                   ||.:|.|.:..|: .|..||
Human   247 CQRDLHGTAGPDRKPFPCPLD-------------------TLRVPPPLTPLSTIRNFTLG----- 287

  Fly   948 QENYPDMQPSS--NGTGYSGGS-----GGSSAAAAAAAAAAAAAVQLAEYSPSTSKGHEILSQVY 1005
                   .||:  .|.|.||||     .|||:||||||||||       |:|     |.:
Human   288 -------GPSAGVTGPGASGGSEGPRLPGSSSAAAAAAAAAA-------YNP-----HHL----- 328

  Fly  1006 QQSTVPLKLVPVKPRKYPNRPSKTPVHERPYACPVENCDRRFSRSDELTRHIRIHTGQKPFQCRI 1070
                 ||:.: ::||||||||||||||||||.||.|.||||||||||||||||||||.|||||||
Human   329 -----PLRPI-LRPRKYPNRPSKTPVHERPYPCPAEGCDRRFSRSDELTRHIRIHTGHKPFQCRI 387

  Fly  1071 CMRSFSRSDHLTTHIRTHTGEKPFSCDICGRKFARSDEKKRHAKVHLKQRIKK 1123
            |||:||||||||||||||||||||:||.||||||||||:|||.|:||:|:.:|
Human   388 CMRNFSRSDHLTTHIRTHTGEKPFACDYCGRKFARSDERKRHTKIHLRQKERK 440

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sr	NP_001262693.1	zf-C2H2	1036..1060	CDD:278523	20/23 (87%)
		C2H2 Zn finger	1038..1060	CDD:275368	19/21 (90%)
		zf-H2C2_2	1052..1077	CDD:290200	22/24 (92%)
		C2H2 Zn finger	1068..1088	CDD:275368	18/19 (95%)
		zf-H2C2_2	1080..1105	CDD:290200	22/24 (92%)
		C2H2 Zn finger	1096..1116	CDD:275368	16/19 (84%)
EGR2	XP_011537729.1	DUF3446	107..179	CDD:403215	16/52 (31%)
		zf-C2H2	353..377	CDD:395048	20/23 (87%)
		C2H2 Zn finger	355..377	CDD:275368	19/21 (90%)
		COG5048	381..>449	CDD:227381	50/60 (83%)
		C2H2 Zn finger	385..405	CDD:275368	18/19 (95%)
		C2H2 Zn finger	413..433	CDD:275368	16/19 (84%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	50	1.000	Domainoid score	I11688
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S2858
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000710
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23235
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2698
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	6	6.040