DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sr and egrh-1

DIOPT Version :9

Sequence 1:	NP_001262693.1	Gene:	sr / 42162	FlyBaseID:	FBgn0003499	Length:	1271	Species:	Drosophila melanogaster
Sequence 2:	NP_510462.2	Gene:	egrh-1 / 181580	WormBaseID:	WBGene00007772	Length:	461	Species:	Caenorhabditis elegans

Alignment Length:	439	Identity:	145/439 - (33%)
Similarity:	190/439 - (43%)	Gaps:	121/439 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   765 PM----SPPSNSLGNSWGLPSPDKTMF--QPPLFSLPAHYATMQQQQQQQQQQQQQQQQQQAAGA 823
            ||    :|..|  |.|...|..|:..|  ..|||: ..|..|:........::.....:|
Worm    58 PMNIDGTPKVN--GFSGFTPQTDQKFFGEHEPLFN-QMHTTTLMPAPSSSYKEPAYSSEQ----- 114

  Fly   824 APSPYDDGRAAAAAAAQHAELLGLTMDCTPLLL----KQPP--------------------PSYA 864
             ||...|       .|:..||||......|.:.    ||.|                    |..:
Worm   115 -PSSSSD-------EAKPKELLGSNSFGVPRMTNGNSKQKPEELTLKDIEISSTGPGGVDSPGLS 171

  Fly   865 GA-----------------SAGFPGLGDLHSSHEQQLQQQQYVRSQPKYQWLDSPADYAQQQQQV 912
            .|                 .||.|.|  :..|....|..|:             |:|..:..|..
Worm   172 AAMFQFSPMVEHFLQNLTNKAGLPEL--VVDSKTAGLNHQE-------------PSDLIKSVQVR 221

  Fly   913 QQVQQQQQQQQTL---VLPGPTSSAS-----------SSNAALGVLIPKQE------------NY 951
            :...:.|:....|   .||..||..|           .||:....:||:.:            ::
Worm   222 RSSIEDQKFSDVLHVPTLPRKTSEPSHLGSSLQNEHPQSNSRPSTVIPRVQRTNTSASLTRSMDH 286

  Fly   952 PDMQP-SSNGTGYSGGSGGSSAAAAAAAAAAAAAVQLAEYSPSTS---------KGHEILSQVYQ 1006
            ..|.| |::...||..:..||.:...:.:.:|:   ||.:.|.|.         ..::..|..:.
Worm   287 SSMSPISAHDDPYSNSASYSSLSTHTSFSDSAS---LAHFEPKTEPMDDYSYNFSDNDFNSFEFS 348

  Fly  1007 QSTVPLKLVPVKPRKYPNRPSKTPVHERPYACPVENCDRRFSRSDELTRHIRIHTGQKPFQCRIC 1071
            .::..||.:..:..|    .||.|:.:|||.||.:.|||||||||||||||||||||||||||||
Worm   349 STSEELKNIGCQKMK----SSKMPLQDRPYKCPRDGCDRRFSRSDELTRHIRIHTGQKPFQCRIC 409

  Fly  1072 MRSFSRSDHLTTHIRTHTGEKPFSCDICGRKFARSDEKKRHAKVHLKQR 1120
            ||:||||||||||:|||||||||||||||||||||||:|||.|||...|
Worm   410 MRAFSRSDHLTTHVRTHTGEKPFSCDICGRKFARSDERKRHTKVHKTSR 458

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sr	NP_001262693.1	zf-C2H2	1036..1060	CDD:278523	19/23 (83%)
		C2H2 Zn finger	1038..1060	CDD:275368	18/21 (86%)
		zf-H2C2_2	1052..1077	CDD:290200	23/24 (96%)
		C2H2 Zn finger	1068..1088	CDD:275368	17/19 (89%)
		zf-H2C2_2	1080..1105	CDD:290200	23/24 (96%)
		C2H2 Zn finger	1096..1116	CDD:275368	17/19 (89%)
egrh-1	NP_510462.2	zf-C2H2	374..398	CDD:278523	19/23 (83%)
		C2H2 Zn finger	376..398	CDD:275368	18/21 (86%)
		zf-H2C2_2	390..415	CDD:290200	23/24 (96%)
		C2H2 Zn finger	406..426	CDD:275368	17/19 (89%)
		zf-H2C2_2	418..443	CDD:290200	23/24 (96%)
		C2H2 Zn finger	434..454	CDD:275368	17/19 (89%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	53	1.000	Domainoid score	I7645
eggNOG	1	0.900	-	-		E33208_3BH2K
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S2858
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000710
OrthoInspector	1	1.000	-	-		otm14753
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR23235
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2698
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	9	8.940