DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sr and Egr4

DIOPT Version :9

Sequence 1:	NP_001262693.1	Gene:	sr / 42162	FlyBaseID:	FBgn0003499	Length:	1271	Species:	Drosophila melanogaster
Sequence 2:	NP_065621.1	Gene:	Egr4 / 13656	MGIID:	99252	Length:	478	Species:	Mus musculus

Alignment Length:	417	Identity:	135/417 - (32%)
Similarity:	177/417 - (42%)	Gaps:	107/417 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   755 PSPQLGVLAGPMSPPSNSLGNSWGLPS-PDKTMFQPPLFSLPAHYATMQQQQQQQQQQQQQQQQQ 818
            |.|:......|:..|         .|: ||..:  |.|:|                       ..
Mouse   113 PGPEAAASRSPLDVP---------FPAGPDALL--PDLYS-----------------------PD 143

  Fly   819 QAAGAAPSPYDDGRAAAAAAAQ----------------HAELLGLTMDCTPLLLKQPPPSYAGAS 867
            .::.|.|..:.:...:|.|.:|                .|......:|......|.|...:...|
Mouse   144 LSSAAFPEAFWEAAPSAGAPSQCLFEPQLSPPDVKPGLRAPPASPALDAAASAFKGPYAPWELLS 208

  Fly   868 AGFPGLGDLHSSHEQQLQQQQYVRSQPKYQWLDS---PADYAQQQQQVQQVQQQQQQQQTLVLPG 929
            ||.||......|. |...:.::.....|.:.|.|   ||:                      |||
Mouse   209 AGVPGNCGSQGSF-QTTPEARFSAVGTKVEDLLSISCPAE----------------------LPG 250

  Fly   930 PTSSASSSNA------ALGVLIPKQENYPDMQPSSNGTGYSGGSGGSSAAAAAA---------AA 979
            |.:....:.|      |.|.|....|..|.:.....|.|.|||.||...||..|         ||
Mouse   251 PAARLYQAGAYDTFSLAPGDLGEGTEGLPALLTPPGGEGGSGGEGGEFLAAPPAQLSPLGLRGAA 315

  Fly   980 AAAAAVQLAEYSPSTSKGHEILSQVYQQSTVPLKLVPVKPRKYPNRPSKTPV-------HERPYA 1037
            .|..:..|....|..       |.|...|:........|.|:...|..|...       |.:.:|
Mouse   316 TADFSKPLVADLPGG-------SGVAAPSSPAASFPAAKARRKGRRGGKCSARCFCPRPHVKAFA 373

  Fly  1038 CPVENCDRRFSRSDELTRHIRIHTGQKPFQCRICMRSFSRSDHLTTHIRTHTGEKPFSCDICGRK 1102
            ||||:|.|.|:|||||.||:|||||.||||||||:|:||||||||||:|||||||||:||:|||:
Mouse   374 CPVESCVRSFARSDELNRHLRIHTGHKPFQCRICLRNFSRSDHLTTHVRTHTGEKPFACDVCGRR 438

  Fly  1103 FARSDEKKRHAKVHLKQRIK-KEKVRG 1128
            ||||||||||:||||||:.: :|:::|
Mouse   439 FARSDEKKRHSKVHLKQKARAEERLKG 465

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sr	NP_001262693.1	zf-C2H2	1036..1060	CDD:278523	16/23 (70%)
		C2H2 Zn finger	1038..1060	CDD:275368	15/21 (71%)
		zf-H2C2_2	1052..1077	CDD:290200	19/24 (79%)
		C2H2 Zn finger	1068..1088	CDD:275368	16/19 (84%)
		zf-H2C2_2	1080..1105	CDD:290200	20/24 (83%)
		C2H2 Zn finger	1096..1116	CDD:275368	16/19 (84%)
Egr4	NP_065621.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	275..302		10/26 (38%)
		zf-C2H2	372..396	CDD:278523	16/23 (70%)
		C2H2 Zn finger	374..396	CDD:275368	15/21 (71%)
		zf-H2C2_2	388..413	CDD:290200	19/24 (79%)
		COG5048	400..>458	CDD:227381	49/57 (86%)
		C2H2 Zn finger	404..424	CDD:275368	16/19 (84%)
		zf-H2C2_2	416..441	CDD:290200	20/24 (83%)
		C2H2 Zn finger	432..452	CDD:275368	16/19 (84%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	50	1.000	Domainoid score	I11592
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR23235
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2698
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.130