DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment sr and Egr2

DIOPT Version :9

Sequence 1:NP_001262693.1 Gene:sr / 42162 FlyBaseID:FBgn0003499 Length:1271 Species:Drosophila melanogaster
Sequence 2:NP_446085.1 Gene:Egr2 / 114090 RGDID:621608 Length:470 Species:Rattus norvegicus


Alignment Length:396 Identity:152/396 - (38%)
Similarity:183/396 - (46%) Gaps:100/396 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly   760 GVLAGPMSPPSNSLGNSWGLPSPDKTMFQPPLFSLPAHYATMQQQQQQQQQQQQQQQQQQAAGAA 824
            |:|.|...|.|.:..:|....||:      ||.:.|....||       .|.|.:.....:....
  Rat   119 GILQGVTPPASTTASSSVTSASPN------PLATGPLGVCTM-------SQTQPELDHLYSPPPP 170

  Fly   825 PSPYDDGRAAAAAAAQHAELLGLTMD---------------CTPLLLKQPPPSYAGASAGF-PGL 873
            |.||.                |.|.|               .|..|..||||||....... |||
  Rat   171 PPPYS----------------GCTGDLYQDPSAFLSPPPTTSTSSLAYQPPPSYPSPKPAMDPGL 219

  Fly   874 ----GDLHSSHEQQLQQQQYVRSQPKYQWLDSPADYAQQQQQVQQVQQQQQQQQTLVLPGPTSSA 934
                .|.........|:..:..:.|..:....|.|                   :|.:|.|.:..
  Rat   220 IPMIPDYPGFFPSPCQRDPHGAAGPDRKPFPCPLD-------------------SLRVPPPLTPL 265

  Fly   935 SS-SNAALGVLIPKQENYPDMQPSSNGTGYSGGSGGSSAAAAAAAAAAAAAVQLAEYSPSTSKGH 998
            |: .|..||            .||:..|| .|.|||..  ......:.:|||....|:|     |
  Rat   266 STIRNFTLG------------GPSAGVTG-PGASGGGE--GPRLPGSGSAAVTATPYNP-----H 310

  Fly   999 EILSQVYQQSTVPLKLVPVKPRKYPNRPSKTPVHERPYACPVENCDRRFSRSDELTRHIRIHTGQ 1063
            .:          ||:.: ::||||||||||||||||||.||.|.||||||||||||||||||||.
  Rat   311 HL----------PLRPI-LRPRKYPNRPSKTPVHERPYPCPAEGCDRRFSRSDELTRHIRIHTGH 364

  Fly  1064 KPFQCRICMRSFSRSDHLTTHIRTHTGEKPFSCDICGRKFARSDEKKRHAKVHLKQRIKKEKVRG 1128
            ||||||||||:||||||||||||||||||||:||.||||||||||:|||.|:||:|:.:|.....
  Rat   365 KPFQCRICMRNFSRSDHLTTHIRTHTGEKPFACDYCGRKFARSDERKRHTKIHLRQKERKSSAPS 429

  Fly  1129 EQQQQQ 1134
            .....|
  Rat   430 SSASAQ 435

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
srNP_001262693.1 zf-C2H2 1036..1060 CDD:278523 20/23 (87%)
C2H2 Zn finger 1038..1060 CDD:275368 19/21 (90%)
zf-H2C2_2 1052..1077 CDD:290200 22/24 (92%)
C2H2 Zn finger 1068..1088 CDD:275368 18/19 (95%)
zf-H2C2_2 1080..1105 CDD:290200 22/24 (92%)
C2H2 Zn finger 1096..1116 CDD:275368 16/19 (84%)
Egr2NP_446085.1 DUF3446 94..166 CDD:403215 15/59 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 126..153 8/32 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 159..178 4/34 (12%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 184..211 8/26 (31%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 275..344 37/87 (43%)
zf-C2H2 337..361 CDD:395048 20/23 (87%)
C2H2 Zn finger 339..361 CDD:275368 19/21 (90%)
COG5048 365..>421 CDD:227381 48/55 (87%)
C2H2 Zn finger 369..389 CDD:275368 18/19 (95%)
C2H2 Zn finger 397..417 CDD:275368 16/19 (84%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 408..470 11/28 (39%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 50 1.000 Domainoid score I11371
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000710
OrthoInspector 1 1.000 - - otm45147
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR23235
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
66.060

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