Protein Alignment htl and Tie1

DIOPT Version :10

• Sequence 1: NP_524394.2
• Gene: htl / 42160
• FlyBaseID: FBgn0010389
• Length: 729
• Species: Drosophila melanogaster
• Sequence 2: NP_445997.1
• Gene: Tie1 / 89806
• RGDID: 621642
• Length: 1137
• Species: Rattus norvegicus
• Alignment Length: 693
• Identity: 206/693 - (29%)
• Similarity: 303/693 - (43%)
• Gaps: 184/693 - (26%)

  Fly   116 PSGSLLTLNCHALGNPEPNI-----TWYRNG----TVDWT------RGYGSLKRNRW-------- 157
            || :|:|.:|     |||.:     :|...|    .|.|:      .|.|.|.| .|
  Rat   535 PS-TLMTTDC-----PEPLLQPWVESWNVEGPDRLRVSWSLPSVPLSGDGFLLR-LWDGARGQER 592

  Fly   158 ----------TLTMEDLVPGDCGNYTCKV----CNSLG----------------CIRHDTQVIVS 192
                      |..:..|.||.  :|...|    |..||                ..||.....:|
  Rat   593 RENISSPQARTALLTGLTPGT--HYQLDVRLYHCTLLGPASPSAHVHLPLSGPPAPRHLRAQALS 655

  Fly   193 DR----VNHKPILMTGPLNLTLVVNSTGSMHCKYLSDL-----TSKKAWIFVPCHGMTNCSNNRS 248
            |.    :...|....||::             ||:.::     :....|:.|.....|: :..|.
  Rat   656 DSEIRLMWQHPEAPPGPIS-------------KYIVEIQVAGGSGDPQWMDVDKPEETS-TTVRG 706

  Fly   249 IIAEDKDQLDFVNVRMEQEG---WYTCVESNSLGQSNSTAYLRVVRSLHVLEAGVASGSLHSTSF 310
            :.|..:   ....||...:|   |...||..:||....:|       ..|.|:.||...|...
  Rat   707 LNASTR---YLFRVRASVQGLGDWSNTVEETTLGNGLQSA-------SPVQESRVAEDGLDQQ-- 759

  Fly   311 VYIFVFGGLIFIFMTTLFVFYAI----RKMKHEKVLKQRIETVHQWTKKVIIFKPEGGGD----- 366
            :.:.|.|.:....:|.|....|:    |...|.:         |.:|.:      .|.|:
  Rat   760 LVLAVVGSVSATCLTILAALLALVCIRRSCLHRR---------HTFTYQ------SGSGEETILQ 809

  Fly   367 -SSGSMDTMIMPVVRIQKQRTTVLQNGNEPAPFNEYEFPLDSNWELPRSHLVLGATLGEGAFGRV 430
             |||::              |...:...:|.|.:   :|: ..||    .:.....:|||.||:|
  Rat   810 FSSGTL--------------TLTRRPKPQPEPLS---YPV-LEWE----DITFEDLIGEGNFGQV 852

  Fly   431 VMAEVN------NAIVAVKMVKEGHTDDDIASLVREMEVMKIIGRHINIINLLGCCSQNGPLYVI 489
            :.|.:.      ||  |:||:||..:::|......|:||:..:|.|.|||||||.|...|.||:.
  Rat   853 IRAMIKKDGLKMNA--AIKMLKEYASENDHRDFAGELEVLCKLGHHPNIINLLGACENRGYLYIA 915

  Fly   490 VEYAPHGNLKDFLYKNR------PFGRDQDRDSSQPPPSPPAHVITEKDLIKFAHQIARGMDYLA 548
            :||||:|||.|||.|:|      .|.|:..          .|..::.:.|::||...|.||.||:
  Rat   916 IEYAPYGNLLDFLRKSRVLETDPAFAREHG----------TASTLSSRQLLRFASDAANGMQYLS 970

  Fly   549 SRRCIHRDLAARNVLVSDDYVLKIADFGLARDIQSTDYYRKNTNGRLPIKWMAPESLQEKFYDSK 613
            .::.||||||||||||.::...|||||||:|   ..:.|.|.|.||||::|||.|||....|.:|
  Rat   971 EKQFIHRDLAARNVLVGENLASKIADFGLSR---GEEVYVKKTMGRLPVRWMAIESLNYSVYTTK 1032

  Fly   614 SDVWSYGILLWEIMTYGQQPYPTIMSAEELYTYLMSGQRMEKPAKCSMNIYILMRQCWHFNADDR 678
            |||||:|:|||||::.|..|| ..|:..|||..|..|.|||:|..|...:|.||||||.....:|
  Rat  1033 SDVWSFGVLLWEIVSLGGTPY-CGMTCAELYEKLPQGYRMEQPRNCDDEVYELMRQCWRDRPYER 1096

  Fly   679 PPFTEIVEYMDKLLQTKEDYLDVDI------ANLDTPPSTSDE 715
            |||.:|...:.::|:.::.|:::.:      |.:|   :|::|
  Rat  1097 PPFAQIALQLGRMLEARKAYVNMSLFENFTYAGID---ATAEE 1136

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
htl	NP_524394.2	Ig	101..191	CDD:472250	28/127 (22%)
		Ig strand B	121..125	CDD:409353	1/3 (33%)
		Ig strand C	134..138	CDD:409353	0/8 (0%)
		Ig strand E	157..161	CDD:409353	2/21 (10%)
		Ig strand F	171..176	CDD:409353	1/4 (25%)
		Ig strand G	184..187	CDD:409353	2/2 (100%)
		Ig	200..289	CDD:472250	18/96 (19%)
		Ig strand B	216..220	CDD:409353	0/3 (0%)
		Ig strand C	229..233	CDD:409353	0/3 (0%)
		Ig strand E	255..259	CDD:409353	0/3 (0%)
		Ig strand F	269..274	CDD:409353	1/4 (25%)
		Ig strand G	282..285	CDD:409353	0/2 (0%)
		Protein Kinases, catalytic domain	404..692	CDD:473864	129/299 (43%)
Tie1	NP_445997.1	ig	130..211	CDD:395002
		Furin-like	217..339	CDD:395614
		EGF_Lam	228..266	CDD:238012
		Ig	351..442	CDD:472250
		Ig strand B	369..373	CDD:409556
		Ig strand C	385..389	CDD:409556
		Ig strand E	410..414	CDD:409556
		Ig strand F	424..429	CDD:409556
		Ig strand G	437..440	CDD:409556
		fn3	450..530	CDD:394996
		fn3	549..631	CDD:394996	18/84 (21%)
		FN3	643..735	CDD:238020	20/108 (19%)
		PTKc_Tie1	835..1131	CDD:270671	131/315 (42%)