DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment htl and Tek

DIOPT Version :10

Sequence 1:NP_524394.2 Gene:htl / 42160 FlyBaseID:FBgn0010389 Length:729 Species:Drosophila melanogaster
Sequence 2:NP_001099207.1 Gene:Tek / 89804 RGDID:620980 Length:1120 Species:Rattus norvegicus


Alignment Length:715 Identity:207/715 - (28%)
Similarity:315/715 - (44%) Gaps:180/715 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly    95 VNVSSKPYWRN-PKKMSFLQTRP----------SGSLLTLN----------CHAL--------GN 130
            :|:||:||:.: |.|...|..:|          ...::|||          |..|        |:
  Rat   463 INISSEPYFGDGPIKSKKLFYKPVNQAWKYIQVMNEIVTLNYLEPRTDYELCVQLVRPGEGGEGH 527

  Fly   131 PEP---------------------------NITWYRNGTVDWTRGYGSLKRNRWT-LTMED---- 163
            |.|                           |:||....|......|  ::..||: .|..|    
  Rat   528 PGPVRRFTTASIGLPPPRGLSLLPKSQTALNLTWQPIFTSSEDEFY--VEVERWSQQTRSDQQNI 590

  Fly   164 LVPGDCGNYTCKVCNSLGCIRHDTQVIVSDRVNHK---------------PILMTGPLNLTLVVN 213
            .||   ||.|..:.|:|   ....|..|..|||.|               .||...|.|:.:.  
  Rat   591 KVP---GNLTSVLLNNL---LPREQYSVRARVNTKAQGEWSEELRAWTLSDILPPQPENIKIT-- 647

  Fly   214 STGSMHCKYLSDLTSKKAWIFVPCHGMTNCSNNRSIIAEDKDQLDFVNVR-----------MEQE 267
                    .::|.|:..:|..|..:.:::......:..:::||...|.::           :|.|
  Rat   648 --------NITDYTALVSWTIVDGYSISSIIIRYKVQGKNEDQHIDVKIKNATITQYQLKGLEPE 704

  Fly   268 GWY--TCVESNSLGQSNSTAYLRVVRSLHVLEAGVASGSLHSTSFVYIFVFGGLIFIFMTTLFVF 330
            ..|  .....|::|.|| .|:.:.:|:|      .|...|.....:.|.:.|......:|.|..|
  Rat   705 TTYHVDIFAENNIGSSN-PAFSQEIRTL------PAPKDLGGGKMLLIAILGSAGMTCITVLLAF 762

  Fly   331 YAIRKMKHEKV---LKQRIETVHQWTKKVIIFKPEGGGDSSGSM----------DTMIMPVVRIQ 382
            ..:.::|...|   :.|..:.|.:  :..:.|       :||::          |..|.||:   
  Rat   763 LIMLQLKRANVQRRMAQAFQNVRE--EPAVQF-------NSGTLALNRKAKNNPDPTIYPVL--- 815

  Fly   383 KQRTTVLQNGNEPAPFNEYEFPLDSNWELPRSHLVLGATLGEGAFGRVVMAEVN----NAIVAVK 443
                          .:|:.:|.               ..:|||.||:|:.|.:.    ....|:|
  Rat   816 --------------DWNDIKFQ---------------DVIGEGNFGQVLKARIKKDGLRMDAAIK 851

  Fly   444 MVKEGHTDDDIASLVREMEVMKIIGRHINIINLLGCCSQNGPLYVIVEYAPHGNLKDFLYKNRPF 508
            .:||..:.||......|:||:..:|.|.|||||||.|...|.||:.:||||||||.|||.|:|..
  Rat   852 RMKEYASKDDHRDFAGELEVLCKLGHHPNIINLLGACEHRGYLYLAIEYAPHGNLLDFLRKSRVL 916

  Fly   509 GRDQDRDSSQPPPSPPAHVITEKDLIKFAHQIARGMDYLASRRCIHRDLAARNVLVSDDYVLKIA 573
                :.|.:....:..|..::.:.|:.||..:|||||||:.::.|||||||||:||.::|:.|||
  Rat   917 ----ETDPAFAIANSTASTLSSQQLLHFAADVARGMDYLSQKQFIHRDLAARNILVGENYIAKIA 977

  Fly   574 DFGLARDIQSTDYYRKNTNGRLPIKWMAPESLQEKFYDSKSDVWSYGILLWEIMTYGQQPYPTIM 638
            ||||:|   ..:.|.|.|.||||::|||.|||....|.:.|||||||:|||||::.|..|| ..|
  Rat   978 DFGLSR---GQEVYVKKTMGRLPVRWMAIESLNYSVYTTNSDVWSYGVLLWEIVSLGGTPY-CGM 1038

  Fly   639 SAEELYTYLMSGQRMEKPAKCSMNIYILMRQCWHFNADDRPPFTEIVEYMDKLLQTKEDYLDVDI 703
            :..|||..|..|.|:|||..|...:|.||||||.....:||.|.:|:..::::|:.::.|::..:
  Rat  1039 TCAELYEKLPQGYRLEKPLNCDDEVYDLMRQCWREKPYERPSFAQILVSLNRMLEERKTYVNTTL 1103

  Fly   704  703
              Rat  1104  1103

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
htlNP_524394.2 Ig 101..191 CDD:472250 31/150 (21%)
Ig strand B 121..125 CDD:409353 3/13 (23%)
Ig strand C 134..138 CDD:409353 2/3 (67%)
Ig strand E 157..161 CDD:409353 1/4 (25%)
Ig strand F 171..176 CDD:409353 2/4 (50%)
Ig strand G 184..187 CDD:409353 0/2 (0%)
Ig 200..289 CDD:472250 19/101 (19%)
Ig strand B 216..220 CDD:409353 0/3 (0%)
Ig strand C 229..233 CDD:409353 0/3 (0%)
Ig strand E 255..259 CDD:409353 2/3 (67%)
Ig strand F 269..274 CDD:409353 1/6 (17%)
Ig strand G 282..285 CDD:409353 1/2 (50%)
Protein Kinases, catalytic domain 404..692 CDD:473864 125/291 (43%)
TekNP_001099207.1 Ig_Tie2_1 24..118 CDD:463089
EGF_Lam 230..275 CDD:238012
IgI_Tie2 348..439 CDD:409556
Ig strand A 348..352 CDD:409556
Ig strand A' 358..362 CDD:409556
Ig strand B 365..374 CDD:409556
Ig strand C 382..387 CDD:409556
Ig strand C' 391..393 CDD:409556
Ig strand D 397..401 CDD:409556
Ig strand E 404..412 CDD:409556
Ig strand F 420..428 CDD:409556
Ig strand G 431..439 CDD:409556
fn3 445..518 CDD:394996 13/54 (24%)
fn3 542..625 CDD:394996 22/90 (24%)
FN3 638..730 CDD:238020 17/102 (17%)
PTKc_Tie2 812..1114 CDD:133219 131/332 (39%)
Blue background indicates that the domain is not in the aligned region.

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