DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment htl and SKM1

DIOPT Version :9

Sequence 1:	NP_524394.2	Gene:	htl / 42160	FlyBaseID:	FBgn0010389	Length:	729	Species:	Drosophila melanogaster
Sequence 2:	NP_014528.1	Gene:	SKM1 / 854036	SGDID:	S000005473	Length:	655	Species:	Saccharomyces cerevisiae

Alignment Length:	682	Identity:	143/682 - (20%)
Similarity:	233/682 - (34%)	Gaps:	195/682 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    83 AADDDDNKADLPVNVSSKPYWRNPKKMSFLQTRPSGSL----------------------LTLNC 125
            |.|..:|.:  |:|  |..|..|.|:..|:.||....|                      .|...
Yeast    73 ATDQKENIS--PIN--SYFYESNSKRSIFISTRTERDLHGWLDAIFAKCPLLSGVSSPTNFTHKV 133

  Fly   126 HA---------LGNPE--------PNIT---WYRNGTV---------DWTRGYGSLKRNRWTLTM 161
            |.         :|.|:        ..||   |.||...         |: .|..:::.|....|.
Yeast   134 HVGFDPKVGNFVGVPDSWAKLLQTSEITYDDWNRNSKAVIKALQFYEDY-NGLDTMQFNDHLNTS 197

  Fly   162 EDLVPGDCGNYTCKVCNSLGCIRHDTQVIVSDRVNHKPILMTGPLNLTLVVNSTGSMHCKYLSDL 226
            .||.|                ::..|:.|::.|.|.    :...::.||....|.|:...|.|:|
Yeast   198 LDLKP----------------LKSPTRYIINKRTNS----IKRSVSRTLRKGKTDSILPVYQSEL 242

  Fly   227 TSKKAWIFVPCHGMTNCSNNRSIIAEDKDQLDFVNV---RMEQEG-WYTCVESNSLGQSNSTAYL 287
                                :.......|...|.|:   ::.:|| .:...||.:..|:....
Yeast   243 --------------------KPFPRPSDDDYKFTNIEDNKVREEGRVHVSKESTADSQTKQLG-- 285

  Fly   288 RVVRSLHVLEAGVASGSLHSTSFVYIFVFGGLIFIFMTTLFVFYAIRKMKHEKVLKQRIETVHQW 352
              .:...|:::.:.....:||              |........|.....|:...|        |
Yeast   286 --KKEQKVIQSHLRRHDNNST--------------FRPHRLAPSAPATKNHDSKTK--------W 326

  Fly   353 TKKVII-FKPEGGGDSSGSMDTMIMPVVRIQKQRTTVLQNGNEPAPFNEYEFPLDSNWELPRSHL 416
            .|:.:: .|   ..|.|..:         |.|.:|..                :|.|   ||.:.
Yeast   327 HKEDLLELK---NNDDSNEI---------IMKMKTVA----------------IDVN---PRPYF 360

  Fly   417 VLGATLGEGAFGRVVMAE-------------------VNNAIVAVKMVKEGHTDDDIASLVREME 462
            .|....|:||.|.|.:::                   |....||:|.::....... ..::.|:.
Yeast   361 QLVEKAGQGASGAVYLSKRIKLPQENDPRFLKSHCHRVVGERVAIKQIRLSEQPKK-QLIMNELL 424

  Fly   463 VMKIIGRHINIINLL-GCCSQNGPLYVIVEYAPHGNLKDFLYKNRPFGRDQDRDSSQPPPSPPAH 526
            ||. ..|..||:|.| .....:..|:||:||...|.|.|.|   ....|....:.|.|
Yeast   425 VMN-DSRQENIVNFLEAYIIDDEELWVIMEYMEGGCLTDIL---DAVARSNTGEHSSP------- 478

  Fly   527 VITEKDLIKFAHQIARGMDYLASRRCIHRDLAARNVLVSDDYVLKIADFGLARDIQSTDYYRKNT 591
             :.|..:.....:..:|:.:|.:::.||||:.:.|:|::...::||.|||...::......|...
Yeast   479 -LNENQMAYIVKETCQGLKFLHNKKIIHRDIKSDNILLNSQGLVKITDFGFCVELTEKRSKRATM 542

  Fly   592 NGRLPIKWMAPESLQEKFYDSKSDVWSYGILLWEIMTYGQQPYPTIMSAEELYTYLMSGQ-RMEK 655
            .| .|. |||||.:.:|.||.|.||||.||:|.| |..|:.||......:.||....:|. ::..
Yeast   543 VG-TPY-WMAPEIVNQKGYDEKVDVWSLGIMLIE-MIEGEPPYLNEDPLKALYLIANNGSPKLRH 604

  Fly   656 PAKCSMNIYILMRQCWHFNADDRPPFTEIVEY 687
            |...|......:..|...|.:.|....:::.:
Yeast   605 PESVSKQTKQFLDACLQVNVESRASVRKLLTF 636

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
htl	NP_524394.2	Ig	112..191	CDD:299845	20/129 (16%)
		IG_like	113..191	CDD:214653	20/128 (16%)
		IG_like	205..289	CDD:214653	15/87 (17%)
		PKc_like	404..692	CDD:304357	80/305 (26%)
		STYKc	416..688	CDD:214568	76/293 (26%)
SKM1	NP_014528.1	PH_Cla4_Ste20	4..113	CDD:270097	13/43 (30%)
		PBD	122..180	CDD:395634	9/57 (16%)
		STKc_PAK	359..640	CDD:270789	76/294 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000